Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.1018 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1197 | 0.4384 | 0.4384 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Schistosoma mansoni | cathepsin s | 0.0371 | 0.1222 | 0.0379 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.1197 | 0.4384 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0652 | 0.2298 | 0.2298 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Onchocerca volvulus | 0.1197 | 0.4384 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1197 | 0.4384 | 0.3845 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0281 | 0.0876 | 0.0876 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0281 | 0.0876 | 0.0876 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0281 | 0.0876 | 0.0876 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0652 | 0.2298 | 0.1559 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Echinococcus granulosus | cathepsin L | 0.0652 | 0.2298 | 0.1559 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0826 | 0.2962 | 0.5946 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.2663 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.0652 | 0.2298 | 0.4054 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.2663 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Brugia malayi | cathepsin L precursor | 0.0281 | 0.0876 | 0.0876 |
Brugia malayi | Cathepsin L-like precursor | 0.0826 | 0.2962 | 0.2962 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1197 | 0.4384 | 0.4384 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0652 | 0.2298 | 0.1559 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1197 | 0.4384 | 0.3845 |
Onchocerca volvulus | 0.1197 | 0.4384 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1197 | 0.4384 | 0.3845 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0652 | 0.2298 | 0.1559 |
Plasmodium vivax | vivapain-3 | 0.0652 | 0.2298 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0652 | 0.2298 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1018 | 0.3698 | 0.6711 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0281 | 0.0876 | 0.0876 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0371 | 0.1222 | 0.1222 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0826 | 0.2962 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1197 | 0.4384 | 0.3845 |
Echinococcus multilocularis | cathepsin b | 0.2663 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0876 | 0.0876 |
Echinococcus granulosus | cathepsin b | 0.2663 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1197 | 0.4384 | 1 |
Onchocerca volvulus | 0.1197 | 0.4384 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.1197 | 0.4384 | 1 |
Onchocerca volvulus | 0.1197 | 0.4384 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1197 | 0.4384 | 0.3845 |
Giardia lamblia | Cathepsin B precursor | 0.1018 | 0.3698 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0848 | 0.3048 | 0.238 |
Echinococcus multilocularis | cysteine protease | 0.1197 | 0.4384 | 0.3845 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0371 | 0.1222 | 0.0379 |
Trypanosoma cruzi | cysteine protease, putative | 0.0652 | 0.2298 | 0.1559 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0826 | 0.2962 | 0.2962 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0281 | 0.0876 | 0.0876 |
Loa Loa (eye worm) | ctsf protein | 0.1197 | 0.4384 | 0.4384 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0876 | 0.0876 |
Echinococcus granulosus | cathepsin l1 | 0.0826 | 0.2962 | 0.2286 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0281 | 0.0876 | 0.0876 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0371 | 0.1222 | 0.1222 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0876 | 0.0876 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0652 | 0.2298 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1197 | 0.4384 | 0.4384 |
Onchocerca volvulus | 0.1197 | 0.4384 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0652 | 0.2298 | 0.4054 |
Loa Loa (eye worm) | fibroinase | 0.1197 | 0.4384 | 0.4384 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1197 | 0.4384 | 0.3845 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0281 | 0.0876 | 0.0876 |
Echinococcus multilocularis | cysteine protease | 0.1197 | 0.4384 | 0.3845 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1197 | 0.4384 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1197 | 0.4384 | 0.3845 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0281 | 0.0876 | 0.0876 |
Toxoplasma gondii | cathepsin CPL | 0.1197 | 0.4384 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.2962 | 0.2962 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1197 | 0.4384 | 0.3845 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1197 | 0.4384 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.2962 | 0.2962 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0826 | 0.2962 | 0.2286 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0281 | 0.0876 | 0.0876 |
Echinococcus granulosus | cathepsin l1 | 0.1197 | 0.4384 | 0.3845 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0652 | 0.2298 | 0.1559 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1197 | 0.4384 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Toxoplasma gondii | cathepsin B | 0.1018 | 0.3698 | 0.8044 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2663 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.1018 | 0.3698 | 0.3698 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1197 | 0.4384 | 0.4384 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1018 | 0.3698 | 0.3093 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0281 | 0.0876 | 0.0876 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1197 | 0.4384 | 0.3845 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Onchocerca volvulus | 0.1197 | 0.4384 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.1197 | 0.4384 | 0.4384 |
Onchocerca volvulus | Cathepsin L homolog | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0652 | 0.2298 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1197 | 0.4384 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0652 | 0.2298 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.2663 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.2663 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Plasmodium vivax | unspecified product | 0.0371 | 0.1222 | 0.0987 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0876 | 0.0876 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0281 | 0.0876 | 0.0876 |
Echinococcus granulosus | cathepsin b | 0.2663 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0826 | 0.2962 | 0.2962 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1197 | 0.4384 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1197 | 0.4384 | 0.4384 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0652 | 0.2298 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0652 | 0.2298 | 0.2298 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0652 | 0.2298 | 0.1559 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1222 | 0.1222 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2663 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0652 | 0.2298 | 0.1559 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2663 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0652 | 0.2298 | 0.4054 |
Onchocerca volvulus | Cathepsin L homolog | 0.1197 | 0.4384 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0371 | 0.1222 | 0.1222 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1197 | 0.4384 | 0.3845 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1197 | 0.4384 | 0.3845 |
Loa Loa (eye worm) | hypothetical protein | 0.1197 | 0.4384 | 0.4384 |
Brugia malayi | Cathepsin L-like precursor | 0.1197 | 0.4384 | 0.4384 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0826 | 0.2962 | 0.2286 |
Onchocerca volvulus | 0.0826 | 0.2962 | 0.5946 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0652 | 0.2298 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1018 | 0.3698 | 0.3093 |
Onchocerca volvulus | Cathepsin F homolog | 0.1197 | 0.4384 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1197 | 0.4384 | 0.3845 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0652 | 0.2298 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Echinococcus granulosus | cysteine protease | 0.0652 | 0.2298 | 0.1559 |
Plasmodium vivax | vivapain-2 | 0.1197 | 0.4384 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0652 | 0.2298 | 0.1559 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1018 | 0.3698 | 0.8044 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1222 | 0.1222 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1197 | 0.4384 | 0.3845 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1222 | 0.1222 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0652 | 0.2298 | 0.1559 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.1018 | 0.3698 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0652 | 0.2298 | 0.1559 |
Brugia malayi | Cathepsin L-like precursor | 0.1197 | 0.4384 | 0.4384 |
Brugia malayi | cathepsin L-like precursor | 0.0826 | 0.2962 | 0.2962 |
Leishmania major | cathepsin L-like protease | 0.1197 | 0.4384 | 1 |
Onchocerca volvulus | 0.1197 | 0.4384 | 1 | |
Plasmodium vivax | unspecified product | 0.0652 | 0.2298 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0371 | 0.1222 | 0.1222 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0371 | 0.1222 | 0.0379 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0826 | 0.2962 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Brugia malayi | fibroinase precursor | 0.0281 | 0.0876 | 0.0876 |
Brugia malayi | Cathepsin L-like precursor | 0.1197 | 0.4384 | 0.4384 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0652 | 0.2298 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0876 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0876 | 0.0876 |
Brugia malayi | Cathepsin L-like precursor | 0.1197 | 0.4384 | 0.4384 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1197 | 0.4384 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 43000 nM | BindingDB_Patents: Binding Assay. The binding affinity and selectivity of candidate molecules yielded from database screening were determined by a fluorescent polarization competitive binding assay using purified baculovirus-expressed human ER beta or ER alpha and a fluorescent estrogen ligand EL Red (PanVera Corp.). | ChEMBL. | No reference |
IC50 (binding) | = 85700 nM | Binding Assay | BINDINGDB. | No reference |
IC50 (binding) | = 43 uM | Binding affinity for human Estrogen receptor beta | ChEMBL. | 15887952 |
IC50 (binding) | = 43 uM | Binding affinity for human Estrogen receptor beta | ChEMBL. | 15887952 |
IC50 (binding) | = 85.7 uM | Binding affinity for human Estrogen receptor Alpha | ChEMBL. | 15887952 |
IC50 (binding) | = 85.7 uM | Binding affinity for human Estrogen receptor Alpha | ChEMBL. | 15887952 |
Selectivity (binding) | = 1.99 | Selectivity for Estrogen receptors alpha and beta | ChEMBL. | 15887952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.