TDR Targets

Basic information

Technical information

TDR Targets ID: 337791
Name: pentyl 4-[2-(3-chlorophenyl)acetyl]oxybutanoa te
MW: 326.815 | Formula: C17H23ClO4
H donors: 0 H acceptors: 2 LogP: 4.31 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCOC(=O)CCCOC(=O)Cc1cccc(c1)Cl
InChi: 1S/C17H23ClO4/c1-2-3-4-10-21-16(19)9-6-11-22-17(20)13-14-7-5-8-15(18)12-14/h5,7-8,12H,2-4,6,9-11,13H2,1H3
InChiKey: JQTLSSLSLKWJOH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[2-(3-chlorophenyl)-1-oxoethoxy]butanoic acid pentyl ester
pentyl 4-[2-(3-chlorophenyl)ethanoyloxy]butanoate
4-[2-(3-chlorophenyl)acetyl]oxybutyric acid amyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0068	0.0504	0.0504
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0079	0.0167
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0068	0.0504	0.1066
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0068	0.0504	0.1066
Entamoeba histolytica	hypothetical protein	0.0039	0.0195	0.0412
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0068	0.0504	0.1066
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0142	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Leishmania major	hypothetical protein, conserved	0.0028	0.0069	0.0146
Brugia malayi	nuclear hormone receptor family member odr-7	0.0032	0.0119	0.0251
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0309	0.0309
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0036	0.016	0.016
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Leishmania major	DNA polymerase eta, putative	0.0034	0.0142	0.0301
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0309	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0464	0.4731	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0119	0.0124
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0068	0.0504	0.0504
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0068	0.0504	0.0525
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0032	0.0119	0.0251
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0032	0.0119	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Brugia malayi	hypothetical protein	0.0036	0.016	0.0338
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0032	0.0119	0.0124
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0036	0.016	0.0338
Brugia malayi	hypothetical protein	0.0032	0.0119	0.0251
Schistosoma mansoni	RAR-like nuclear receptor	0.0068	0.0504	0.0504
Echinococcus multilocularis	dna polymerase eta	0.0049	0.0298	0.031
Brugia malayi	RNA binding protein	0.0069	0.0515	0.1088
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0032	0.0119	0.0251
Brugia malayi	ecdysteroid receptor	0.0068	0.0504	0.1066
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0119	0.0119
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0079	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0036	0.016	0.0167
Loa Loa (eye worm)	steroid hormone receptor	0.0068	0.0504	0.1066
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0068	0.0504	0.1066
Brugia malayi	hypothetical protein	0.0028	0.0069	0.0146
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0079	0.0167
Onchocerca volvulus	Protein ultraspiracle homolog	0.0068	0.0504	1
Echinococcus granulosus	transcription factor Dp 1	0.0268	0.2644	0.2644
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0068	0.0504	0.1066
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0068	0.0504	0.0504
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0309	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0298	0.0629
Entamoeba histolytica	hypothetical protein	0.0039	0.0195	0.0412
Schistosoma mansoni	thyroid hormone receptor	0.0068	0.0504	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0036	0.016	0.0338
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0068	0.0504	0.0504
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0068	0.0504	0.1066
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0068	0.0504	0.0525
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0068	0.0504	0.0525
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.0032	0.0119	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0309	0.0309
Echinococcus granulosus	dna polymerase eta	0.0049	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.0039	0.0195	0.0195
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0068	0.0504	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Echinococcus multilocularis	FTZ F1 alpha	0.0068	0.0504	0.0525
Trypanosoma cruzi	DNA polymerase eta, putative	0.0049	0.0298	0.0629
Brugia malayi	Nuclear hormone receptor-like 1	0.0068	0.0504	0.1066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0309	0.0309
Schistosoma mansoni	DNA polymerase eta	0.0049	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0068	0.0504	0.1066
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.016	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Brugia malayi	photoreceptor-specific nuclear receptor	0.0068	0.0504	0.1066
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0515	0.0515
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0921	0.9614	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0464	0.4731	1
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0068	0.0504	0.1066
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0079	0.0167
Echinococcus granulosus	thyroid hormone receptor alpha	0.0032	0.0119	0.0119
Brugia malayi	nuclear hormone receptor	0.0068	0.0504	0.1066
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0032	0.0119	0.0119
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0515	0.1088
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0068	0.0504	0.0525
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0464	0.4731	0.4731
Onchocerca volvulus		0.0068	0.0504	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.016	0.0338
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0068	0.0504	0.0504
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0515	0.1088
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0142	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0032	0.0119	0.0119
Brugia malayi	nuclear receptor NHR-67	0.0032	0.0119	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0032	0.0119	0.0119
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0464	0.4731	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0032	0.0119	0.0251
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0068	0.0504	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0068	0.0504	0.1066
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0079	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Echinococcus multilocularis	geminin	0.0185	0.1755	0.1826
Brugia malayi	Nuclear hormone receptor E75	0.0032	0.0119	0.0251
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0069	0.0146
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0515	0.0536
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0068	0.0504	0.1066
Brugia malayi	hypothetical protein	0.0036	0.016	0.0338
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0036	0.016	0.016
Brugia malayi	steroid hormone receptor	0.0068	0.0504	0.1066
Brugia malayi	TAR-binding protein	0.0069	0.0515	0.1088
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0032	0.0119	0.0119
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0068	0.0504	0.1066
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0309	0.0309
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0068	0.0504	0.1066
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0068	0.0504	0.1066
Echinococcus granulosus	geminin	0.0185	0.1755	0.1755
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0068	0.0504	0.0504
Echinococcus multilocularis	ecdysone induced protein 78C	0.0068	0.0504	0.0525
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0068	0.0504	0.1066
Trypanosoma brucei	DNA polymerase eta, putative	0.0049	0.0298	0.0629
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0195	0.0195
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0032	0.0119	0.0119
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0464	0.4731	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0515	0.1088
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0069	0.0146
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0032	0.0119	0.0251
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0515	0.0515
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0464	0.4731	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0195	0.0412
Schistosoma mansoni	thyroid hormone receptor	0.0068	0.0504	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0036	0.016	0.0338
Onchocerca volvulus	Bile acid receptor homolog	0.0068	0.0504	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0195	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0036	0.016	0.0338
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0068	0.0504	0.1066
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0068	0.0504	0.1066
Echinococcus granulosus	ecdysone induced protein 78C	0.0068	0.0504	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0079	1
Schistosoma mansoni	nuclear receptor	0.0032	0.0119	0.0119
Echinococcus granulosus	nuclear receptor nhr 48	0.0032	0.0119	0.0119
Brugia malayi	conserved hypotetical protein	0.0032	0.0119	0.0251
Echinococcus multilocularis	transcription factor Dp 1	0.0268	0.2644	0.275
Leishmania major	DNA polymerase eta, putative	0.0049	0.0298	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0069	0.0146
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0032	0.0119	0.0251
Echinococcus multilocularis	nuclear receptor nhr 48	0.0032	0.0119	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Brugia malayi	nuclear receptor NHR-88	0.0068	0.0504	0.1066
Schistosoma mansoni	nuclear receptor	0.0032	0.0119	0.0119
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0119	0.0119
Brugia malayi	hypothetical protein	0.0039	0.0195	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Schistosoma mansoni	retinoic acid receptor RXR	0.0957	1	1
Brugia malayi	nuclear receptor RXR	0.0032	0.0119	0.0251
Schistosoma mansoni	flap endonuclease-1	0.0026	0.005	0.005
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0068	0.0504	0.0525
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0464	0.4731	0.4921
Echinococcus granulosus	FTZ F1 alpha	0.0068	0.0504	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0504	0.1066
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.016	0.0338
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0515	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0068	0.0504	0.1066
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0515	0.0515
Brugia malayi	ecdysone receptor	0.0032	0.0119	0.0251
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0	0.5
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0464	0.4731	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0068	0.0504	0.0504
Schistosoma mansoni	hypothetical protein	0.0185	0.1755	0.1755
Schistosoma mansoni	nuclear hormone receptor	0.0068	0.0504	0.0504
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0068	0.0504	0.1066
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0309	0.0653
Schistosoma mansoni	zinc finger protein	0.0032	0.0119	0.0119
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0119	0.0119
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0069	0.0146
Brugia malayi	Steroid receptor seven-up type 2	0.0068	0.0504	0.1066
Brugia malayi	ImpB/MucB/SamB family protein	0.0049	0.0298	0.0629
Brugia malayi	tailless protein	0.0032	0.0119	0.0251
Brugia malayi	nuclear receptor RXR	0.0036	0.016	0.0338
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0068	0.0504	0.1066
Brugia malayi	Flap endonuclease-1	0.0028	0.0079	0.0167
Loa Loa (eye worm)	nuclear hormone receptor	0.0032	0.0119	0.0251
Loa Loa (eye worm)	DR-78	0.0032	0.0119	0.0251
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0079	0.1335
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0464	0.4731	1
Schistosoma mansoni	coup transcription factor	0.0068	0.0504	0.0504
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0068	0.0504	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0036	0.016	0.0338
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0032	0.0119	0.0124
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0079	0.0079
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0068	0.0504	0.0504
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0079	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0068	0.0504	0.0525
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0079	0.0167
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0079	0.0167
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0068	0.0504	0.0504
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0068	0.0504	0.0504
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0068	0.0504	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Brugia malayi	Nuclear hormone receptor E75	0.0032	0.0119	0.0251
Brugia malayi	nuclear hormone receptor	0.0032	0.0119	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Schistosoma mansoni	hypothetical protein	0.0185	0.1755	0.1755
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0309	0.0322
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0068	0.0504	0.0504
Schistosoma mansoni	nuclear receptor nhr-48	0.0032	0.0119	0.0119
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0464	0.4731	0.4731
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0068	0.0504	0.0525
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0079	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0309	0.0309
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0515	0.1088
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0251
Entamoeba histolytica	hypothetical protein	0.0039	0.0195	0.0412
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0119	0.0251

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	Inhibitory concentration against mouse soluble epoxide hydrolase (sEH) at 0.12 uM	ChEMBL.	15887969
IC50 (binding)	> 100 uM	Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM	ChEMBL.	15887969
IC50 (binding)	> 100 uM	Inhibitory concentration against mouse soluble epoxide hydrolase (sEH) at 0.12 uM	ChEMBL.	15887969
IC50 (binding)	> 100 uM	Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM	ChEMBL.	15887969

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL195542
PubChem: 11427381

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 337791