Detailed information for compound 341691

Basic information

Technical information
  • TDR Targets ID: 341691
  • Name: N-[(4-chlorophenyl)methyl]-7-(2-hydroxyethyl) -2-(3-hydroxypropyl)-4-oxothieno[2,3-b]pyridi ne-5-carboxamide
  • MW: 420.91 | Formula: C20H21ClN2O4S
  • H donors: 3 H acceptors: 4 LogP: 3.16 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCn1cc(C(=O)NCc2ccc(cc2)Cl)c(=O)c2c1sc(c2)CCCO
  • InChi: 1S/C20H21ClN2O4S/c21-14-5-3-13(4-6-14)11-22-19(27)17-12-23(7-9-25)20-16(18(17)26)10-15(28-20)2-1-8-24/h3-6,10,12,24-25H,1-2,7-9,11H2,(H,22,27)
  • InChiKey: ILSLXJXFTGBRED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-chlorophenyl)methyl]-7-(2-hydroxyethyl)-2-(3-hydroxypropyl)-4-oxo-thieno[2,3-b]pyridine-5-carboxamide
  • N-[(4-chlorophenyl)methyl]-7-(2-hydroxyethyl)-2-(3-hydroxypropyl)-4-oxo-5-thieno[2,3-b]pyridinecarboxamide
  • N-(4-chlorobenzyl)-7-(2-hydroxyethyl)-2-(3-hydroxypropyl)-4-keto-thieno[2,3-b]pyridine-5-carboxamide
  • AIDS-340076
  • AIDS340076
  • Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-4,7-dihydro-7-(2-hydroxyethyl)-2-(3-hydroxypropyl)-4-oxo-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 DNA polymerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium parvum DNA polymerase delta catalytic subunit. DNAQ-like 3-5 exonuclease; RNAseH fold Get druggable targets OG5_127429 All targets in OG5_127429
Theileria parva DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania donovani DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei gambiense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Neospora caninum DNA polymerase (EC 2.7.7.7), related Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania infantum DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium knowlesi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium hominis DNA polymerase family B subunit Get druggable targets OG5_127429 All targets in OG5_127429
Babesia bovis DNA polymerase delta subunit Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania major DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Schistosoma mansoni DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus granulosus DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium falciparum DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium berghei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Loa Loa (eye worm) DNA-directed DNA polymerase III Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium yoelii DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus multilocularis DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania mexicana DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma congolense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania braziliensis DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Brugia malayi DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Giardia lamblia DNA polymerase delta, catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog Get druggable targets OG5_127429 All targets in OG5_127429
Toxoplasma gondii DNA polymerase Get druggable targets OG5_127429 All targets in OG5_127429
Schistosoma japonicum ko:K02327 DNA polymerase delta subunit 1, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium vivax DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans hypothetical protein Get druggable targets OG5_127429 All targets in OG5_127429
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0049 0.2305 0.4263
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.3499 0.6479
Echinococcus granulosus glycoprotein Antigen 5 0.0091 0.5337 0.989
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.003 0.097 0.0963
Loa Loa (eye worm) hypothetical protein 0.0028 0.0795 0.1472
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.003 0.097 0.1785
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.003 0.097 0.1797
Echinococcus granulosus Mastin 0.0091 0.5337 0.989
Loa Loa (eye worm) hypothetical protein 0.0091 0.5337 0.989
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.6808 0.8837
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0008 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.5333
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.7703 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Brugia malayi DNA polymerase delta catalytic subunit 0.0092 0.5396 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0008 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.3162 0.3157
Onchocerca volvulus 0.0091 0.5337 0.9871
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0092 0.5396 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0008 0.5
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.6808 0.8837
Echinococcus granulosus lamin 0.0028 0.0795 0.146
Mycobacterium ulcerans hypothetical protein 0.0091 0.5337 1
Plasmodium falciparum glutathione reductase 0.0049 0.2305 0.4271
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.2305 0.4263
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0075 0.4186 0.7754
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0008 0.0015
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.003 0.097 0.1785
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0795 0.146
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Echinococcus multilocularis lamin 0.0028 0.0795 0.146
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.003 0.097 0.1785
Onchocerca volvulus 0.0091 0.5337 0.9871
Brugia malayi jmjC domain containing protein 0.0061 0.3162 0.5854
Loa Loa (eye worm) trypsin family protein 0.0091 0.5337 0.989
Loa Loa (eye worm) hypothetical protein 0.0091 0.5337 0.989
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3499 0.3494
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.989
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0092 0.5396 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0091 0.5337 0.989
Plasmodium vivax glutathione reductase, putative 0.0049 0.2305 0.4263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0758 0.1405
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.2305 0.4263
Schistosoma mansoni jumonji domain containing protein 0.0061 0.3162 0.3157
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.003 0.097 0.1785
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0092 0.5396 1
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0092 0.5396 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0795 0.1472
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0092 0.5396 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0092 0.5396 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.7703 1
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.003 0.097 0.1785
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.003 0.097 0.1785
Loa Loa (eye worm) hypothetical protein 0.0091 0.5337 0.989
Echinococcus multilocularis enteropeptidase 0.0091 0.5337 0.989
Onchocerca volvulus 0.0091 0.5337 0.9871
Brugia malayi Trypsin family protein 0.0091 0.5337 0.989
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.6808 0.8837
Echinococcus multilocularis musashi 0.0028 0.0795 0.146
Toxoplasma gondii DNA polymerase 0.0092 0.5396 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0795 0.1472
Echinococcus granulosus intermediate filament protein 0.0028 0.0795 0.146
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0092 0.5396 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.3499 0.6484
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.003 0.097 0.1785
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.003 0.097 0.1785
Echinococcus multilocularis tar DNA binding protein 0.0066 0.3499 0.6479
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0092 0.5396 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.3499 0.6484
Plasmodium falciparum thioredoxin reductase 0.0049 0.2305 0.4271
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.003 0.097 0.1797
Onchocerca volvulus DNA polymerase homolog 0.003 0.097 0.0381
Echinococcus multilocularis glycoprotein Antigen 5 0.0091 0.5337 0.989
Echinococcus multilocularis lamin dm0 0.0028 0.0795 0.146
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3499 0.3494
Loa Loa (eye worm) hypothetical protein 0.0091 0.5337 0.989
Onchocerca volvulus 0.0091 0.5337 0.9871
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.3162 0.3157
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.6808 0.8837
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0008 0.0015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.7703 1
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.003 0.097 0.1785
Brugia malayi Thioredoxin reductase 0.0049 0.2305 0.4263
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.003 0.097 0.0963
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0092 0.5396 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni intermediate filament proteins 0.0028 0.0795 0.0787
Onchocerca volvulus 0.0091 0.5337 0.9871
Loa Loa (eye worm) hypothetical protein 0.0091 0.5337 0.989
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.3162 0.5854
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.003 0.097 0.1785
Brugia malayi intermediate filament protein 0.0028 0.0795 0.146
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.5333
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.2305 0.2985
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0092 0.5396 0.5393
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0008 0.0015
Brugia malayi RNA binding protein 0.0066 0.3499 0.6479
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.5333
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.003 0.097 0.1785
Loa Loa (eye worm) glutathione reductase 0.0049 0.2305 0.4271
Brugia malayi DNA polymerase alpha catalytic subunit 0.003 0.097 0.1785
Loa Loa (eye worm) TAR-binding protein 0.0066 0.3499 0.6484
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.2305 0.4263
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.2305 0.4271
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.3162 0.5854
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0092 0.5396 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.7703 1
Echinococcus granulosus transmembrane protease serine 3 0.0091 0.5337 0.989
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni lamin 0.0028 0.0795 0.0787
Plasmodium falciparum glutathione reductase 0.0017 0.0008 0.0015
Leishmania major trypanothione reductase 0.0049 0.2305 0.4263
Brugia malayi glutathione reductase 0.0049 0.2305 0.4263
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.003 0.097 0.0963
Echinococcus multilocularis Mastin 0.0091 0.5337 0.989
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.003 0.097 0.1785
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0091 0.5337 0.989
Toxoplasma gondii DNA polymerase family B protein 0.003 0.097 0.1785
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.003 0.097 0.1785
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0091 0.5337 0.5333
Echinococcus granulosus tar DNA binding protein 0.0066 0.3499 0.6479
Loa Loa (eye worm) hypothetical protein 0.003 0.097 0.1797
Treponema pallidum NADH oxidase 0.0017 0.0008 0.5
Brugia malayi hypothetical protein 0.0091 0.5337 0.989
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0091 0.5337 0.5333
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.6808 0.8837
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3499 0.3494
Mycobacterium tuberculosis Probable reductase 0.0112 0.6808 0.8837
Echinococcus granulosus lamin dm0 0.0028 0.0795 0.146
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.003 0.097 0.1785
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.003 0.097 0.1785
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.003 0.097 0.1797
Schistosoma mansoni hypothetical protein 0.0091 0.5337 0.5333
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3499 0.3494
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Loa Loa (eye worm) hypothetical protein 0.0091 0.5337 0.989
Plasmodium vivax DNA polymerase alpha, putative 0.003 0.097 0.1785
Schistosoma mansoni tar DNA-binding protein 0.0066 0.3499 0.3494
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0008 0.0015
Echinococcus granulosus enteropeptidase 0.0091 0.5337 0.989
Trichomonas vaginalis DNA polymerase II, putative 0.003 0.097 0.1797
Brugia malayi DNA polymerase family B containing protein 0.003 0.097 0.1785
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.3162 0.5854
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0091 0.5337 0.989
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0092 0.5396 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.3162 0.586
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.003 0.097 0.1785
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0092 0.5396 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Brugia malayi Trypsin family protein 0.0091 0.5337 0.989
Echinococcus multilocularis transmembrane protease serine 3 0.0091 0.5337 0.989
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.2305 0.4263
Brugia malayi jmjC domain containing protein 0.0061 0.3162 0.5854
Brugia malayi Trypsin family protein 0.0091 0.5337 0.989
Loa Loa (eye worm) hypothetical protein 0.0091 0.5337 0.989
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.003 0.097 0.1785
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.003 0.097 0.0381
Brugia malayi Trypsin family protein 0.0091 0.5337 0.989
Brugia malayi TAR-binding protein 0.0066 0.3499 0.6479
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.3162 0.5854
Onchocerca volvulus 0.0091 0.5337 0.9871
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.003 0.097 0.1785
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.003 0.097 0.1785
Schistosoma mansoni hypothetical protein 0.0091 0.5337 0.5333
Trypanosoma brucei trypanothione reductase 0.0049 0.2305 0.4263
Plasmodium falciparum thioredoxin reductase 0.0017 0.0008 0.0015
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0091 0.5337 0.989
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.003 0.097 0.0381
Schistosoma mansoni cercarial elastase (S01 family) 0.0091 0.5337 0.5333
Schistosoma mansoni lamin 0.0028 0.0795 0.0787
Brugia malayi Trypsin-like protease protein 5 0.0091 0.5337 0.989

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.75 uM Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C ChEMBL. 16134946
IC50 (binding) = 0.75 uM Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 degrees C ChEMBL. 16134946
IC50 (functional) = 1.8 uM Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO ChEMBL. 16134946
IC50 (functional) = 1.8 uM Antiviral activity against human cytomegalovirus (Davis strain) grown on human foreskin fibroblast cells determined by reduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO ChEMBL. 16134946

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16134946

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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