Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0818 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0325 | 0.1929 | 0.1653 |
Chlamydia trachomatis | glutamine binding protein | 0.0207 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0228 | 0.0331 | 0.5 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0228 | 0.0331 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.078 | 0.939 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0207 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0228 | 0.0331 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0207 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0288 | 0.132 | 0.1023 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0228 | 0.0331 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0493 | 0.4673 | 0.4491 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0553 | 0.5662 | 0.5514 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0553 | 0.5662 | 0.5514 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0493 | 0.4673 | 0.4491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.