Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor NMDA | 0.0493 | 0.4673 | 0.4491 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0288 | 0.132 | 0.1023 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0228 | 0.0331 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0288 | 0.132 | 0.1023 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0207 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0493 | 0.4673 | 0.4491 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0553 | 0.5662 | 0.5514 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0553 | 0.5662 | 0.5514 |
Schistosoma mansoni | glutamate receptor NMDA | 0.078 | 0.939 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0228 | 0.0331 | 0.5 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0228 | 0.0331 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0325 | 0.1929 | 0.1653 |
Chlamydia trachomatis | glutamine binding protein | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0818 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0207 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0228 | 0.0331 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0207 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0207 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.132 | 0.1023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.