Detailed information for compound 342393

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 158.218 | Formula: C7H10O2S
  • H donors: 1 H acceptors: 2 LogP: 1.75 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1SC(=C(C1=O)C)O
  • InChi: 1S/C7H10O2S/c1-3-5-6(8)4(2)7(9)10-5/h5,9H,3H2,1-2H3
  • InChiKey: MIKKIHBNFIGEBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Schistosoma mansoni glycogen phosphorylase 0.011 0.1014 0.145
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0495 0.4043
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0066 0.0495 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Leishmania major hypothetical protein, conserved 0.0066 0.0495 1
Onchocerca volvulus 0.0055 0.0362 0.2516
Loa Loa (eye worm) hypothetical protein 0.0066 0.0495 0.0804
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0066 0.0495 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0804
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0586
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0478 0.537 0.8695
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0066 0.0495 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0055 0.0362 0.009
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0066 0.0495 0.0586
Echinococcus multilocularis glycogen phosphorylase 0.011 0.1014 0.145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0239 0.0161
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0239 0.0161
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0352 0.388 0.6217
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0544 0.6154 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Echinococcus multilocularis cytidine deaminase 0.0055 0.0362 0.0365
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni glycogen phosphorylase 0.011 0.1014 0.145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Loa Loa (eye worm) hypothetical protein 0.0066 0.0495 0.0804
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0066 0.0495 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0274 0.151
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0495 0.4043
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Loa Loa (eye worm) hypothetical protein 0.0066 0.0495 0.0804
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0239 0.0389
Echinococcus granulosus cytidine deaminase 0.0055 0.0362 0.0365
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Loa Loa (eye worm) glycogen phosphorylase 0.011 0.1014 0.1647
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.0274 0.151
Trichomonas vaginalis cytidine deaminase, putative 0.0055 0.0362 0.2516
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0544 0.6154 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0066 0.0495 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.011 0.1014 1
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0036 0.0142 0.2878
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Echinococcus multilocularis geminin 0.0174 0.1766 0.2702
Leishmania major cAMP-specific phosphodiesterase, putative 0.0066 0.0495 1
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0055 0.0362 0.7309
Trypanosoma brucei cytidine deaminase 0.0055 0.0362 0.7309
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0478 0.537 0.8695
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Brugia malayi carbohydrate phosphorylase 0.011 0.1014 0.1888
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Entamoeba histolytica glycogen phosphorylase, putative 0.011 0.1014 1
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0036 0.0142 0.0231
Echinococcus granulosus geminin 0.0174 0.1766 0.2702
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0478 0.537 0.8726
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0066 0.0495 0.0921
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0048 0.0274 0.0133
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0478 0.537 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0066 0.0495 0.0586
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0066 0.0495 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0239 0.0161
Trichomonas vaginalis cytidine deaminase, putative 0.0055 0.0362 0.2516
Mycobacterium ulcerans cytidine deaminase 0.0055 0.0362 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0495 0.4043
Leishmania major hypothetical protein, conserved 0.0066 0.0495 1
Onchocerca volvulus 0.0055 0.0362 0.2516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0239 0.0161
Giardia lamblia Cytidine deaminase 0.0055 0.0362 0.0365
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0066 0.0495 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0544 0.6154 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.011 0.1014 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0055 0.0362 0.0588
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0066 0.0495 0.0586
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0586
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0066 0.0495 0.0586
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Giardia lamblia Glycogen phosphorylase 0.011 0.1014 0.145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Schistosoma mansoni hypothetical protein 0.0174 0.1766 0.2702
Entamoeba histolytica glycogen phosphorylase, putative 0.011 0.1014 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0868 1 1
Loa Loa (eye worm) PDE1B protein 0.0066 0.0495 0.0804
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0868 1 0.5
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0544 0.6154 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0544 0.6154 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0036 0.0142 0.0265
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0066 0.0495 0.0586
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0231
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0586
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0066 0.0495 0.0921
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0495 0.0921
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Loa Loa (eye worm) hypothetical protein 0.0544 0.6154 1
Echinococcus multilocularis solute carrier family 28 0.0352 0.388 0.6217
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Schistosoma mansoni hypothetical protein 0.0174 0.1766 0.2702
Entamoeba histolytica cytidine deaminase, putative 0.0055 0.0362 0.2516
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0239 0.0161
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0274 0.151
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0239 0.0161
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0066 0.0495 0.0921
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0495 0.0921
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trypanosoma cruzi cytidine deaminase-like protein 0.0055 0.0362 0.7309
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0352 0.388 0.6217
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0495 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0239 0.0445
Plasmodium falciparum phosphodiesterase delta, putative 0.0066 0.0495 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0544 0.6154 1
Onchocerca volvulus Glycogen phosphorylase homolog 0.011 0.1014 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Echinococcus granulosus solute carrier family 28 0.0352 0.388 0.6217
Giardia lamblia hypothetical protein 0.0066 0.0495 0.0586
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.023 0.243 0.3805
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0352 0.388 0.6217
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0066 0.0495 0.0586
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0868 1 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0495 0.0586
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0495 0.0586
Echinococcus granulosus Glycosyl transferase family 35 0.011 0.1014 0.145
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0066 0.0495 1
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.033 0.3622 0.5
Echinococcus granulosus glycogen phosphorylase 0.011 0.1014 0.145
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.033 0.3622 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0495 0.0921
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0495 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0544 0.6154 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0066 0.0495 0.0586
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.0495 1
Leishmania major cytidine deaminase-like protein 0.0055 0.0362 0.7309
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Giardia lamblia Hypothetical protein 0.0066 0.0495 0.0586
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0066 0.0495 0.0586
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0066 0.0495 0.0586
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0239 0.0161
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Echinococcus multilocularis glycogen phosphorylase 0.011 0.1014 0.145
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0495 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0066 0.0495 0.0586
Echinococcus multilocularis Glycosyl transferase, family 35 0.011 0.1014 0.145
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus granulosus glycogen phosphorylase 0.011 0.1014 0.145
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni glycogen phosphorylase 0.0048 0.0274 0.0219
Brugia malayi cytidine deaminase, identical 0.0055 0.0362 0.0673
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 316 uM In vitro inhibitory concentration against erythrocytic stages of chloroquine and pyrimethamine resistant K1 strain of Plasmodium falciparum ChEMBL. 16161997
IC50 (functional) > 316 uM In vitro inhibitory concentration against erythrocytic stages of chloroquine and pyrimethamine resistant K1 strain of Plasmodium falciparum ChEMBL. 16161997
IC50 (functional) > 568 uM Inhibitory concentration against Trypanosoma cruzi [Tulahuen strain C2C4] in rat skeletal myoblasts upon incubation at 37 degrees C for 4 days in 5% CO2 ChEMBL. 16161997
IC50 (functional) > 568 uM Inhibitory concentration against Trypanosoma brucei rhodesiense STIB 900 upon incubation at 37 degrees C in 5% CO2 for 72 hours ChEMBL. 16161997
IC50 (functional) > 568 uM Inhibitory concentration against Trypanosoma cruzi [Tulahuen strain C2C4] in rat skeletal myoblasts upon incubation at 37 degrees C for 4 days in 5% CO2 ChEMBL. 16161997
IC50 (functional) > 568 uM Inhibitory concentration against Trypanosoma brucei rhodesiense STIB 900 upon incubation at 37 degrees C in 5% CO2 for 72 hours ChEMBL. 16161997
Inhibition (binding) % Percent inhibition of recombinant Plasmodium falciparum Beta-Ketoacyl-acyl carrier protein synthase III activity (MBP-pfKASIII) expressed in E. coli cells using [1-14C]-acetyl-CoA as radioligand upon incubation at 37 degrees C for 15 minutes with compound dissloved in 2% DMSO at 10 uM; NA = no activity ChEMBL. 16161997
Inhibition (binding) NA 0 % Percent inhibition of recombinant Plasmodium falciparum Beta-Ketoacyl-acyl carrier protein synthase III activity (MBP-pfKASIII) expressed in E. coli cells using [1-14C]-acetyl-CoA as radioligand upon incubation at 37 degrees C for 15 minutes with compound dissloved in 2% DMSO at 10 uM; NA = no activity ChEMBL. 16161997

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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