Detailed information for compound 342963

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.801 | Formula: C16H19ClN4O2
  • H donors: 1 H acceptors: 2 LogP: 1.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C(/C=C/c2cccc(c2)Cl)NC2C1N(C)C(=O)N(C2=O)C
  • InChi: 1S/C16H19ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-13-14(19)20(2)16(23)21(3)15(13)22/h4-9,12-14,18H,1-3H3/b8-7+
  • InChiKey: JTPRUPCZQCGCFK-BQYQJAHWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0201 0.0966 0.7172
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Schistosoma mansoni hypothetical protein 0.0015 0 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0005 0.0016
Entamoeba histolytica hypothetical protein 0.0041 0.0132 0.2282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0197 0.0574
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0096 0.0279
Brugia malayi hypothetical protein 0.0041 0.0132 0.0397
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0162 0.289
Brugia malayi Protein kinase domain containing protein 0.0048 0.0171 0.0513
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0197 0.0574
Onchocerca volvulus 0.0148 0.0691 0.4943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0197 0.0574
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0371
Echinococcus multilocularis muscleblind protein 0.0146 0.0682 0.1982
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0096 0.0279
Echinococcus multilocularis 0.0047 0.0163 0.0473
Loa Loa (eye worm) O-methyltransferase 0.0201 0.0966 0.2907
Brugia malayi Pre-SET motif family protein 0.0034 0.0096 0.0289
Brugia malayi jmjC domain containing protein 0.0058 0.022 0.0662
Schistosoma mansoni o-methyltransferase 0.0201 0.0966 0.281
Schistosoma mansoni o-methyltransferase 0.0201 0.0966 0.281
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.022 0.064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0197 0.0594
Schistosoma mansoni tyrosine kinase 0.0151 0.0704 0.2048
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0561 0.163
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0001 0.0002
Brugia malayi polk-prov protein 0.0035 0.0103 0.0311
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0966 0.2907
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0197 0.0574
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0094 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0096 0.0279
Schistosoma mansoni intermediate filament proteins 0.0031 0.0079 0.023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0096 0.0279
Brugia malayi 6-phosphofructokinase 0.0123 0.0561 0.1687
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0015 0 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0132 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0103 0.1841
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0079 0.0238
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0005 0.0016
Echinococcus granulosus expressed conserved protein 0.0091 0.0392 0.1139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0197 0.0574
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0162 0.0471
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0103 0.1841
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0005 0.0016
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0422 0.1227
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0561 0.3823
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0197 0.0594
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0093 0.4054
Schistosoma mansoni hypothetical protein 0.0197 0.0947 0.2755
Trypanosoma brucei unspecified product 0.0039 0.0123 0.2197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0197 0.0574
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0561 0.3823
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0162 0.289
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0044 0.0789
Brugia malayi jmjC domain containing protein 0.0058 0.022 0.0662
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.022 0.064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0561 0.3823
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0093 1
Echinococcus multilocularis musashi 0.0031 0.0079 0.023
Entamoeba histolytica hypothetical protein 0.0041 0.0132 0.2282
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0049 0.0866
Schistosoma mansoni tyrosine kinase 0.0081 0.0341 0.0993
Loa Loa (eye worm) hypothetical protein 0.0031 0.0079 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0422 0.127
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0093 0.5
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0135 0.0394
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.0561 0.163
Mycobacterium tuberculosis Probable methyltransferase 0.0201 0.0966 0.1079
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.0561 0.3823
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0044 0.0049
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.0866
Schistosoma mansoni hypothetical protein 0.0015 0 0.0001
Brugia malayi O-methyltransferase 0.0201 0.0966 0.2907
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0002
Schistosoma mansoni patched 1 0.0041 0.0135 0.0394
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.1734 0.8954 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0135 0.0346
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0096 0.4179
Echinococcus granulosus GPCR family 2 0.0015 0 0.0001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0001 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0162 0.289
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0171 0.0496
Schistosoma mansoni lamin 0.0031 0.0079 0.023
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0561 0.1687
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0093 0.4054
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.5215
Echinococcus granulosus dna polymerase kappa 0.0046 0.0162 0.0471
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0316
Echinococcus multilocularis expressed conserved protein 0.0091 0.0392 0.1139
Brugia malayi phosphofructokinase 0.0123 0.0561 0.1687
Echinococcus multilocularis dna polymerase eta 0.0016 0.0005 0.0016
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0171 0.0496
Loa Loa (eye worm) hypothetical protein 0.0041 0.0135 0.0407
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0001 0.0061
Schistosoma mansoni tyrosine kinase 0.0048 0.0171 0.0496
Loa Loa (eye worm) hypothetical protein 0.0051 0.0184 0.0553
Schistosoma mansoni tyrosine kinase 0.008 0.0337 0.098
Loa Loa (eye worm) hypothetical protein 0.0049 0.0174 0.0524
Brugia malayi hypothetical protein 0.0025 0.0049 0.0146
Loa Loa (eye worm) hypothetical protein 0.0096 0.0422 0.127
Schistosoma mansoni hypothetical protein 0.0033 0.0094 0.0273
Loa Loa (eye worm) hypothetical protein 0.0146 0.0682 0.2051
Loa Loa (eye worm) hypothetical protein 0.0034 0.0096 0.0289
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.022 0.064
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0561 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.023 0.0668
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.0561 0.1687
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0371
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.023 0.0668
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0174 0.0524
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0135 0.0394
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0371
Schistosoma mansoni lamin 0.0031 0.0079 0.023
Leishmania major hypothetical protein, conserved 0.0025 0.0049 0.0866
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0001 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0001 0.0026
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0174 0.0524
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0001 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.023 0.0256
Echinococcus granulosus lamin 0.0031 0.0079 0.023
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0561 1
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0132 0.0384
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0132 0.0384
Schistosoma mansoni o-methyltransferase 0.0201 0.0966 0.281
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0093 0.9702
Onchocerca volvulus 0.0034 0.0096 0.0137
Echinococcus granulosus lamin dm0 0.0031 0.0079 0.023
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0093 1
Brugia malayi 6-phosphofructokinase 0.0123 0.0561 0.1687
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.0162 0.0564
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0 0.0001
Brugia malayi O-methyltransferase family protein 0.0201 0.0966 0.2907
Brugia malayi O-methyltransferase family protein 0.0201 0.0966 0.2907
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0093 0.4054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0316
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.1147 0.3449
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.022 0.064
Echinococcus multilocularis insulin receptor 0.0048 0.0171 0.0496
Loa Loa (eye worm) hypothetical protein 0.0033 0.0094 0.0282
Schistosoma mansoni tyrosine kinase 0.008 0.0337 0.098
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0079 0.0238
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.0561 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0341 0.0993
Echinococcus granulosus geminin 0.0197 0.0947 0.2755
Echinococcus multilocularis protein patched 0.0041 0.0135 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Schistosoma mansoni tyrosine kinase 0.008 0.0337 0.098
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.023 1
Leishmania major DNA polymerase kappa, putative 0.0024 0.0044 0.0789
Schistosoma mansoni tyrosine kinase 0.0048 0.0171 0.0496
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0079 0.0238
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0341 0.0993
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0005 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.023 0.0668
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.023 0.0069
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0 0.0001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0005 0.0016
Plasmodium vivax SET domain protein, putative 0.0034 0.0096 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Echinococcus multilocularis lamin 0.0031 0.0079 0.023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0162 0.289
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0422 0.7504
Brugia malayi hypothetical protein 0.0148 0.0691 0.2077
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.023 0.4096
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0005 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0096 0.0279
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.043 0.125
Echinococcus multilocularis protein dispatched 1 0.0047 0.0166 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0093 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0001 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0162 0.289
Mycobacterium ulcerans methyltransferase 0.0201 0.0966 0.0817
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.0866
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.0561 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0096 0.0279
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0146
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0201 0.0966 0.5
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0093 0.9702
Brugia malayi intermediate filament protein 0.0031 0.0079 0.0238
Trichomonas vaginalis set domain proteins, putative 0.0268 0.1316 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0422 0.1227
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.0561 0.163
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0005 0.0095
Schistosoma mansoni DNA polymerase eta 0.0016 0.0005 0.0016
Brugia malayi Furin-like cysteine rich region family protein 0.0151 0.0704 0.2119
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Schistosoma mansoni hypothetical protein 0.0015 0 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0197 0.0574
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0146 0.0682 0.2051
Schistosoma mansoni tyrosine kinase 0.0081 0.0341 0.0993
Schistosoma mansoni jumonji domain containing protein 0.0058 0.022 0.064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.023 0.0069
Entamoeba histolytica hypothetical protein 0.0041 0.0132 0.2282
Schistosoma mansoni hypothetical protein 0.004 0.0128 0.0371
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0637 0.1854
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.5215
Brugia malayi O-methyltransferase family protein 0.0201 0.0966 0.2907
Schistosoma mansoni hypothetical protein 0.0041 0.0132 0.0384
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0561 1
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0682 0.1982
Loa Loa (eye worm) phosphofructokinase 0.0123 0.0561 0.1687
Onchocerca volvulus 0.0201 0.0966 0.7172
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0162 0.289
Echinococcus granulosus muscleblind protein 0.0146 0.0682 0.1982
Echinococcus multilocularis lamin dm0 0.0031 0.0079 0.023
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.0561 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0001 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0162 0.289
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0005 0.0016
Brugia malayi small heat shock protein 0.0654 0.3324 1
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.0561 0.163
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.0561 0.0405
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.0561 0.0626
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0171 0.0513
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0016
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0049 0.506
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.0704 0.2048
Brugia malayi Latrophilin receptor protein 2 0.0015 0 0.0001
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.022 0.064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0 0.0001
Echinococcus multilocularis geminin 0.0197 0.0947 0.2755
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0311
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0049 0.2114
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.022 0.064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0096 0.0279
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0044 0.0789
Loa Loa (eye worm) hypothetical protein 0.0148 0.0691 0.2077
Loa Loa (eye worm) hypothetical protein 0.0654 0.3324 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0637 0.1854
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.023 0.0668
Echinococcus granulosus microtubule associated protein 2 0.0676 0.3439 1
Schistosoma mansoni o-methyltransferase 0.0201 0.0966 0.281
Loa Loa (eye worm) TK/EGFR protein kinase 0.0151 0.0704 0.2119
Brugia malayi Muscleblind-like protein 0.0146 0.0682 0.2051
Entamoeba histolytica hypothetical protein 0.0041 0.0132 0.2282
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.0704 0.2048
Echinococcus granulosus intermediate filament protein 0.0031 0.0079 0.023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0001 0.001
Onchocerca volvulus 0.0268 0.1316 1
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0005 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.3439 1
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.0561 1
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.3439 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0002
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0135 0.0394
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0201 0.0966 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.0162 0.0564
Echinococcus granulosus dna polymerase eta 0.0016 0.0005 0.0016
Brugia malayi Pre-SET motif family protein 0.0235 0.1147 0.3449
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0005 0.0095
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.022 0.0662
Leishmania major DNA polymerase eta, putative 0.0016 0.0005 0.0095
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0089 0.026
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0093 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0174 0.0524
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0123 0.2197
Echinococcus granulosus insulin receptor 0.0048 0.0171 0.0496
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0229
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0001 0.0063
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0001 0.001
Echinococcus multilocularis GPCR, family 2 0.0015 0 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0001 0.0002
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0341 0.0993
Brugia malayi CHE-14 protein 0.0041 0.0135 0.0407
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.023 0.0069
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0135 0.0407
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0005 0.0016
Brugia malayi isocitrate dehydrogenase 0.0015 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0197 0.0947 0.2755

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 100 uM Inhibition constant against human recombinant Monoamine oxidase-B ChEMBL. 16137882
Ki (binding) = 100 uM Inhibition constant against human recombinant Monoamine oxidase-B ChEMBL. 16137882

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.