Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0228 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0369 | 0.0608 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0228 | 0.0303 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0228 | 0.0644 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0006 | 0.0028 | 0.5 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0306 | 0.0895 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0.0028 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0686 | 0.1129 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0006 | 0.0028 | 0.0046 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0394 | 0.0578 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0024 | 0.0306 | 0.0432 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0024 | 0.0306 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0138 | 0.0354 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0072 | 0.0044 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0852 | 0.1403 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0228 | 0.0375 |
Echinococcus granulosus | dnaJ subfamily B | 0.04 | 0.6075 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0228 | 0.0303 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0228 | 0.0644 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0045 | 0.0074 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0024 | 0.0306 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0228 | 0.0644 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.0754 | 0.0728 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0228 | 0.0303 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0686 | 0.066 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0394 | 0.0648 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0208 | 0.313 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0228 | 0.0644 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0228 | 0.3035 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0306 | 0.0895 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0686 | 0.1129 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0686 | 0.1063 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0369 | 0.5183 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0.0306 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0228 | 0.7191 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0228 | 0.0303 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Toxoplasma gondii | hypothetical protein | 0.0656 | 1 | 1 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0024 | 0.0306 | 0.0895 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0228 | 0.0644 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0228 | 0.711 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0228 | 0.0375 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0.0306 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0138 | 0.0354 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0686 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0072 | 0.0044 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0228 | 0.0375 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0686 | 0.1063 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0208 | 0.313 | 1 |
Onchocerca volvulus | 0.0028 | 0.0369 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0228 | 0.02 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0072 | 0.0044 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0394 | 0.0648 |
Echinococcus multilocularis | dnaJ subfamily B | 0.04 | 0.6075 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0228 | 0.7191 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0686 | 0.1129 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0228 | 0.0303 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0228 | 0.0303 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0024 | 0.0306 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0228 | 0.3035 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0656 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Leishmania major | hypothetical protein, conserved | 0.0208 | 0.313 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0369 | 0.0342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0686 | 0.1063 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0228 | 0.711 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0208 | 0.313 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0686 | 0.1063 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0228 | 0.0644 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0306 | 1 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0138 | 0.0354 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.007 | 0.0634 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0228 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0306 | 1 |
Schistosoma mansoni | hypothetical protein | 0.04 | 0.6075 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0228 | 0.0644 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0228 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0138 | 0.0354 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0.0306 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0394 | 0.0578 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0024 | 0.0306 | 0.0432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0138 | 0.0354 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0228 | 0.0644 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0228 | 0.0644 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Plaque reduction (functional) | = 0 % | Percentage plaque reduction was determined against venezuelan equine encephalitis(VEE) virus in african green monkey kidney (vero,V) at a conc of 250-500 microg/mL. Toxic level(1000 microg/mL) | ChEMBL. | 7143371 |
Plaque reduction (functional) | = 0 % | Percentage plaque reduction was determined against venezuelan equine encephalitis(VEE) virus in african green monkey kidney (vero,V) at a conc of 100-250 microg/mL. Toxic level(1000 microg/mL) | ChEMBL. | 7143371 |
Plaque reduction (functional) | = 0 % | Percentage plaque reduction was determined against venezuelan equine encephalitis(VEE) virus in african green monkey kidney (vero,V) at a conc of 25-100 microg/mL. Toxic level(1000 microg/mL) | ChEMBL. | 7143371 |
Plaque reduction (functional) | = 0 % | Percentage plaque reduction was determined against venezuelan equine encephalitis(VEE) virus in african green monkey kidney (vero,V) at a conc of <25 microg/mL. Toxic level(1000 microg/mL) | ChEMBL. | 7143371 |
Plaque reduction (functional) | = 10 % | Percentage plaque reduction was determined against rift valley fever(RVF) virus in african green monkey kidney (vero,V) at a conc of 250-500 microg/mL. Toxic level(1000 microg/mL); 10-30 | ChEMBL. | 7143371 |
Plaque reduction (functional) | = 10 % | Percentage plaque reduction was determined against pichinde(PICH) virus in african green monkey kidney (vero,V).Toxic level(1000 microg/mL); 10-30 | ChEMBL. | 7143371 |
Plaque reduction (functional) | = 61 % | Percentage plaque reduction was determined against yellow fever(YF) virus in african green monkey kidney (vero,V).Toxic level(1000 microg/mL); 61-90 | ChEMBL. | 7143371 |
Plaque reduction (functional) | = 61 % | Percentage plaque reduction was determined against Sandfly fever (SF) virus in african green monkey kidney (vero,V) at a conc of 25-100 microg/mL. Toxic level(1000 microg/mL); 61-90 | ChEMBL. | 7143371 |
Virus rating (functional) | = 0 | In vitro antiviral activity against herpes simplex type 1 (HSV-1) virus was determined in african green monkey kidney (vero,V) expressed as virus rating. Toxic level(1000 microg/mL) | ChEMBL. | 7143371 |
Virus rating (functional) | = 1 | In vitro antiviral activity against vaccinia(VV) virus was determined in african green monkey kidney (vero,V) expressed as virus rating. Toxic level(1000 microg/mL) | ChEMBL. | 7143371 |
Virus rating (functional) | = 1.1 | In vitro antiviral activity against parainfluenza type 3(para 3) virus was determined in african green monkey kidney (vero,V) expressed as virus rating. Toxic level(1000 microg/mL) | ChEMBL. | 7143371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.