Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1D | References | |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1B | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0505 | 0.1084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.3205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.0694 | 0.0694 |
Trypanosoma brucei | RNA helicase, putative | 0.0505 | 0.1084 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.043 | 0.0835 | 0.7707 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0387 | 0.0694 | 0.6401 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.1899 | 0.1899 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0847 | 0.2214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3205 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0847 | 0.2214 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0821 | 0.2126 | 0.2126 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0847 | 0.2214 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Functional activity in [35S]GTPgammaS assay for 5HT1A receptor | ChEMBL. | 16219465 |
Activity (functional) | 0 | Functional activity in in FLIPR assay for 5HT1B receptor | ChEMBL. | 16219465 |
Emax (functional) | = 10 % | Intrinsic activity for 5HT1A receptor in [35S]GTPgammaS assay | ChEMBL. | 16219465 |
Emax (functional) | = 10 % | Intrinsic activity for 5HT1A receptor in [35S]GTPgammaS assay | ChEMBL. | 16219465 |
Emax (functional) | = 20 % | Intrinsic activity for 5HT1B receptor in FLIPR assay | ChEMBL. | 16219465 |
Emax (functional) | = 20 % | Intrinsic activity for 5HT1B receptor in FLIPR assay | ChEMBL. | 16219465 |
Ki (functional) | = 0.5 nM | Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR | ChEMBL. | 16219465 |
Ki (functional) | = 0.5 nM | Inhibitory activity against human recombinant 5HT1B receptor co-expressed with G-protein chimera Gqo5 in HEK293 cells by FLIPR | ChEMBL. | 16219465 |
Ki (functional) | = 0.7 nM | Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptor | ChEMBL. | 16219465 |
Ki (functional) | = 0.7 nM | Displacement of [35S]GTPgammaS from human recombinant 5HT1A receptor | ChEMBL. | 16219465 |
Ki (binding) | = 41.1 nM | Inhibitory activity against Adrenergic alpha1 receptor | ChEMBL. | 16219465 |
Ki (binding) | = 41.1 nM | Inhibitory activity against Adrenergic alpha1 receptor | ChEMBL. | 16219465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.