TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 404.422 | Formula: C21H20N6O3
H donors: 1 H acceptors: 4 LogP: 3.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1)OC)Oc1ncccc1c1n[nH]c(n1)N(c1ccncc1)C
InChi: 1S/C21H20N6O3/c1-27(14-6-9-22-10-7-14)21-24-19(25-26-21)18-5-4-8-23-20(18)30-17-12-15(28-2)11-16(13-17)29-3/h4-13H,1-3H3,(H,24,25,26)
InChiKey: BXEYKLNDRLDKES-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0056	0.0886	0.1526
Schistosoma mansoni	retinoic acid receptor RXR	0.0015	0.008	0.0208
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.002	0.0186	0.0186
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0036	0.0486	0.0735
Echinococcus multilocularis	musashi	0.0042	0.0601	0.0601
Mycobacterium ulcerans	acyl-CoA synthetase	0.0015	0.0096	0.0131
Echinococcus granulosus	thioredoxin glutathione reductase	0.0025	0.0281	0.0426
Brugia malayi	hypothetical protein	0.0034	0.046	0.1001
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0015	0.0096	0.0131
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0025	0.0281	0.0281
Plasmodium falciparum	glutathione reductase	0.0025	0.0275	0.546
Loa Loa (eye worm)	intermediate filament protein	0.0042	0.0601	0.1504
Brugia malayi	Intermediate filament tail domain containing protein	0.0042	0.0601	0.1373
Echinococcus multilocularis	FTZ F1 alpha	0.0015	0.008	0.008
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0048	0.0728	0.1901
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0024	0.0264	0.0486
Echinococcus granulosus	geminin	0.0132	0.2348	0.3551
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0015	0.008	0.012
Onchocerca volvulus		0.0015	0.0096	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0032	0.0425	0.0909
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0048	0.0728	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0029	0.0355	0.1769
Schistosoma mansoni	glutaminase	0.0208	0.3827	1
Leishmania major	trypanothione reductase	0.0025	0.0275	0.2829
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0015	0.0096	0.0152
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0048	0.0728	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0261	0.0623
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0015	0.008	0.0153
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.008	0.0208
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0015	0.008	0.0208
Leishmania major	hypothetical protein, conserved	0.0036	0.0486	0.6173
Echinococcus multilocularis	muscleblind protein	0.0211	0.3879	0.3879
Loa Loa (eye worm)	glutaminase 2	0.0208	0.3827	0.9865
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0036	0.0486	0.0486
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0015	0.0096	0.0131
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0015	0.008	0.012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.008	0.012
Brugia malayi	Inositol-1	0.0048	0.0728	0.1708
Brugia malayi	intermediate filament protein	0.0042	0.0601	0.1373
Schistosoma mansoni	inositol monophosphatase	0.0048	0.0728	0.1904
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.008	0.0208
Plasmodium vivax	thioredoxin reductase, putative	0.0025	0.0275	0.546
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0425	0.1048
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0024	0.0264	0.0691
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0063	0.1008	0.1737
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0015	0.0096	0.0131
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.008	0.0208
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0036	0.0486	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0261	0.0623
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0056	0.0886	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0601	0.1504
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0015	0.008	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0171	0.0389
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0036	0.0486	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0261	0.0623
Onchocerca volvulus		0.0037	0.0509	0.8227
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0034	0.0463	0.1147
Brugia malayi	exodeoxyribonuclease III family protein	0.0029	0.0355	0.0726
Brugia malayi	latrophilin 2 splice variant baaae	0.0022	0.0227	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0211	0.3879	1
Loa Loa (eye worm)	thioredoxin reductase	0.0025	0.0275	0.0659
Onchocerca volvulus		0.0034	0.046	0.7292
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0015	0.008	0.008
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0015	0.008	0.0208
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0029	0.0355	0.1769
Schistosoma mansoni	survival motor neuron protein	0.0037	0.0509	0.1329
Schistosoma mansoni	hypothetical protein	0.0132	0.2348	0.6136
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0016	0.0107	0.0161
Brugia malayi	hypothetical protein	0.0024	0.0261	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0195
Trypanosoma cruzi	PAB1-binding protein , putative	0.0036	0.0486	0.4663
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0048	0.0728	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0029	0.0355	0.0537
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0024	0.0264	0.0486
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0032	0.0425	0.1048
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0056	0.0886	0.1526
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0024	0.0261	0.0478
Plasmodium falciparum	ataxin-2 like protein, putative	0.0036	0.0486	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0029	0.0355	0.4098
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0056	0.0886	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0486	0.1207
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0015	0.0096	0.0131
Brugia malayi	glutaminase DH11.1	0.0208	0.3827	0.9863
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0029	0.0355	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.008	0.008
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0012	0.0021	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.008	0.0208
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0029	0.0355	0.7183
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0036	0.0486	0.107
Mycobacterium ulcerans	glutaminase	0.0208	0.3827	0.663
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0036	0.0486	0.1207
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0148	0.266	0.461
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Mycobacterium tuberculosis	Probable oxidoreductase	0.0063	0.1008	0.1737
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0029	0.0355	0.5
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0043	0.0631	0.1082
Trypanosoma cruzi	PAB1-binding protein , putative	0.0036	0.0486	0.4663
Plasmodium vivax	ataxin-2 like protein, putative	0.0036	0.0486	1
Echinococcus granulosus	muscleblind protein	0.0211	0.3879	0.5865
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0096	0.0044
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0037	0.0509	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0096	0.0152
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0015	0.008	0.0208
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0015	0.008	0.0208
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0032	0.0425	0.0909
Onchocerca volvulus	Protein cycle homolog	0.0024	0.0264	0.3543
Echinococcus granulosus	inositol monophosphatase 1	0.0048	0.0728	0.1102
Schistosoma mansoni	coup transcription factor	0.0015	0.008	0.0208
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0015	0.008	0.008
Echinococcus multilocularis	ecdysone induced protein 78C	0.0015	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0261	0.0623
Schistosoma mansoni	intermediate filament proteins	0.0042	0.0601	0.1571
Echinococcus granulosus	aryl hydrocarbon receptor	0.0034	0.0463	0.07
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0012	0.0021	0.0021
Echinococcus granulosus	lamin	0.0042	0.0601	0.0909
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0015	0.008	0.0208
Trypanosoma brucei	PAB1-binding protein , putative	0.0036	0.0486	0.0887
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0308	0.5761	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0048	0.0728	0.1075
Mycobacterium tuberculosis	Probable reductase	0.0056	0.0886	0.1526
Schistosoma mansoni	inositol monophosphatase	0.0048	0.0728	0.1904
Echinococcus multilocularis	neuropeptide receptor A26	0.0353	0.6613	0.6613
Trypanosoma brucei	beta lactamase	0.0148	0.266	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0036	0.0486	0.0486
Mycobacterium tuberculosis	Probable dehydrogenase	0.0056	0.0886	0.1526
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0063	0.1008	0.1737
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0015	0.008	0.008
Plasmodium falciparum	ataxin-2 like protein, putative	0.0036	0.0486	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.002	0.0186	0.0281
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0043	0.0631	0.2086
Brugia malayi	hypothetical protein	0.0023	0.0242	0.0429
Schistosoma mansoni	ap endonuclease	0.0029	0.0355	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Echinococcus granulosus	neuropeptide receptor A26	0.0353	0.6613	1
Loa Loa (eye worm)	steroid hormone receptor	0.0015	0.008	0.0153
Schistosoma mansoni	lamin	0.0042	0.0601	0.1571
Mycobacterium ulcerans	acyl-CoA synthetase	0.0015	0.0096	0.0131
Echinococcus multilocularis	muscleblind protein 1	0.0211	0.3879	0.3879
Echinococcus multilocularis	neuropeptide s receptor	0.0353	0.6613	0.6613
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Trichomonas vaginalis	glutaminase, putative	0.0208	0.3827	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0107	0.0279
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0034	0.0463	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0211	0.3879	1
Toxoplasma gondii	exonuclease III APE	0.0029	0.0355	0.1769
Brugia malayi	glutathione reductase	0.0025	0.0275	0.0514
Echinococcus granulosus	ecdysone induced protein 78C	0.0015	0.008	0.012
Echinococcus granulosus	FTZ F1 alpha	0.0015	0.008	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0036	0.0486	0.1271
Schistosoma mansoni	RAR-like nuclear receptor	0.0015	0.008	0.0208
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0148	0.266	1
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0096	0.0044
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0048	0.0728	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0186	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0171	0.0389
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0015	0.008	0.008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0015	0.0096	0.0131
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0029	0.0355	0.7183
Mycobacterium ulcerans	hypothetical protein	0.0015	0.0096	0.0131
Schistosoma mansoni	ap endonuclease	0.0029	0.0355	0.0928
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0015	0.008	0.012
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Schistosoma mansoni	hypothetical protein	0.0037	0.0509	0.1329
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0048	0.0728	1
Plasmodium falciparum	thioredoxin reductase	0.0025	0.0275	0.546
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0036	0.0486	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0227	0.0534
Echinococcus multilocularis	survival motor neuron protein 1	0.018	0.3283	0.3283
Loa Loa (eye worm)	glutaminase	0.0208	0.3827	0.9865
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0016	0.0107	0.0107
Brugia malayi	Muscleblind-like protein	0.0211	0.3879	1
Schistosoma mansoni	hypothetical protein	0.0132	0.2348	0.6136
Brugia malayi	Thioredoxin reductase	0.0025	0.0275	0.0514
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0015	0.008	0.012
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0048	0.0728	0.1233
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0096	0.0044
Brugia malayi	hypothetical protein	0.018	0.3283	0.8432
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0195
Brugia malayi	hypothetical protein	0.0024	0.0264	0.0486
Echinococcus multilocularis	inositol monophosphatase 1	0.0048	0.0728	0.0728
Mycobacterium ulcerans	lipoprotein LpqF	0.0148	0.266	0.4598
Schistosoma mansoni	lamin	0.0042	0.0601	0.1571
Echinococcus granulosus	intermediate filament protein	0.0042	0.0601	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0195
Echinococcus granulosus	survival motor neuron protein 1	0.018	0.3283	0.4964
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0048	0.0728	0.1075
Loa Loa (eye worm)	hypothetical protein	0.018	0.3283	0.8456
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0024	0.0264	0.0632
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0015	0.008	0.0153
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0056	0.0886	0.3082
Onchocerca volvulus		0.0042	0.0601	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0227	0.0592
Echinococcus granulosus	neuropeptide s receptor	0.0353	0.6613	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0048	0.0728	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0025	0.0275	0.0463
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0015	0.008	0.008
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0022	0.0228	0.0538
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0308	0.5761	1
Plasmodium vivax	glutathione reductase, putative	0.0025	0.0275	0.546
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0029	0.0355	0.0603
Trichomonas vaginalis	inositol monophosphatase, putative	0.0048	0.0728	0.1075
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0042	0.0601	0.1504
Echinococcus granulosus	lamin dm0	0.0042	0.0601	0.0909
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0015	0.008	0.0153
Onchocerca volvulus		0.0042	0.0601	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0029	0.0355	0.4098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0015	0.008	0.0153
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.008	0.012
Loa Loa (eye worm)	glutathione reductase	0.0025	0.0275	0.0659
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0029	0.0355	0.0336
Brugia malayi	cytoplasmic intermediate filament protein	0.0022	0.0228	0.0391
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0015	0.008	0.0153
Echinococcus multilocularis	lamin dm0	0.0042	0.0601	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0586	0.1466
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0063	0.1008	0.3556
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0029	0.0355	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0034	0.046	0.1138
Brugia malayi	hypothetical protein	0.0036	0.0486	0.1071
Echinococcus multilocularis	geminin	0.0132	0.2348	0.2348
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.008	0.008
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0029	0.0355	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0015	0.008	0.0153
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0015	0.008	0.0208
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0029	0.0355	0.0867
Echinococcus multilocularis	lamin	0.0042	0.0601	0.0601
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0015	0.008	0.0153
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0015	0.008	0.012
Toxoplasma gondii	LsmAD domain-containing protein	0.0036	0.0486	0.4663
Loa Loa (eye worm)	inositol-1	0.0048	0.0728	0.1834

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	0	Cell cycle arrest in A431 cells by accumulation at G2/M phase cell	ChEMBL.	16198562
Inhibition (functional)	= 44 %	Cell cycle arrest in A431 cells by accumulation at G2/M phase cell at 0.1uM	ChEMBL.	16198562
Inhibition (functional)	= 44 %	Cell cycle arrest in A431 cells by accumulation at G2/M phase cell at 0.1uM	ChEMBL.	16198562
Inhibition (binding)	= 68 %	Inhibition of tubulin polymerization in bovine brain at 10 uM	ChEMBL.	16198562
Inhibition (binding)	= 68 %	Inhibition of tubulin polymerization in bovine brain at 10 uM	ChEMBL.	16198562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 347741