Detailed information for compound 347949

Basic information

Technical information
  • TDR Targets ID: 347949
  • Name: 5-hydroxy-2,4-dimethyl-2-propan-2-ylthiophen- 3-one
  • MW: 186.271 | Formula: C9H14O2S
  • H donors: 1 H acceptors: 2 LogP: 2.38 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1=C(C)C(=O)C(S1)(C)C(C)C
  • InChi: 1S/C9H14O2S/c1-5(2)9(4)7(10)6(3)8(11)12-9/h5,11H,1-4H3
  • InChiKey: KYJSBIWSKYNDJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-hydroxy-2-isopropyl-2,4-dimethyl-thiophen-3-one
  • 5-hydroxy-2-isopropyl-2,4-dimethyl-3-thiophenone
  • 5-hydroxy-2,4-dimethyl-2-propan-2-yl-thiophen-3-one
  • 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-(1-methylethyl)-
  • AIDS-410676
  • AIDS410676

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Loa Loa (eye worm) hypothetical protein 0.0544 0.6154 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0495 0.0921
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Echinococcus multilocularis solute carrier family 28 0.0352 0.388 0.6217
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0036 0.0142 0.0265
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0544 0.6154 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0066 0.0495 0.0586
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0544 0.6154 1
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0868 1 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0066 0.0495 0.0921
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0586
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0231
Giardia lamblia Glycogen phosphorylase 0.011 0.1014 0.145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0066 0.0495 0.0586
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0586
Loa Loa (eye worm) PDE1B protein 0.0066 0.0495 0.0804
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0868 1 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni hypothetical protein 0.0174 0.1766 0.2702
Entamoeba histolytica glycogen phosphorylase, putative 0.011 0.1014 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis glycogen phosphorylase, putative 0.011 0.1014 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0544 0.6154 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0066 0.0495 0.0586
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0055 0.0362 0.0588
Onchocerca volvulus Glycogen phosphorylase homolog 0.011 0.1014 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0544 0.6154 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0066 0.0495 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0239 0.0445
Echinococcus granulosus solute carrier family 28 0.0352 0.388 0.6217
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0352 0.388 0.6217
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0495 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0239 0.0161
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Trypanosoma cruzi cytidine deaminase-like protein 0.0055 0.0362 0.7309
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0495 0.0921
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0066 0.0495 0.0921
Schistosoma mansoni hypothetical protein 0.0174 0.1766 0.2702
Entamoeba histolytica cytidine deaminase, putative 0.0055 0.0362 0.2516
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0274 0.151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0239 0.0161
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Giardia lamblia Hypothetical protein 0.0066 0.0495 0.0586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0066 0.0495 0.0586
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0066 0.0495 0.0586
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0544 0.6154 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0495 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0066 0.0495 0.0921
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.0495 1
Leishmania major cytidine deaminase-like protein 0.0055 0.0362 0.7309
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0066 0.0495 0.0586
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0495 0.0586
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0868 1 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0066 0.0495 0.0586
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.033 0.3622 0.5
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.033 0.3622 1
Echinococcus granulosus glycogen phosphorylase 0.011 0.1014 0.145
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0066 0.0495 1
Echinococcus granulosus Glycosyl transferase family 35 0.011 0.1014 0.145
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0495 0.0586
Giardia lamblia hypothetical protein 0.0066 0.0495 0.0586
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0352 0.388 0.6217
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.023 0.243 0.3805
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus granulosus glycogen phosphorylase 0.011 0.1014 0.145
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni glycogen phosphorylase 0.0048 0.0274 0.0219
Brugia malayi cytidine deaminase, identical 0.0055 0.0362 0.0673
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0495 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.011 0.1014 0.145
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0066 0.0495 0.0586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis glycogen phosphorylase 0.011 0.1014 0.145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0239 0.0161
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0066 0.0495 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0478 0.537 0.8695
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0066 0.0495 1
Echinococcus multilocularis glycogen phosphorylase 0.011 0.1014 0.145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0239 0.0161
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0066 0.0495 0.0586
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0055 0.0362 0.009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0066 0.0495 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0804
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0066 0.0495 0.0586
Plasmodium falciparum phosphodiesterase gamma, putative 0.0066 0.0495 1
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0495 0.4043
Loa Loa (eye worm) hypothetical protein 0.0066 0.0495 0.0804
Onchocerca volvulus 0.0055 0.0362 0.2516
Leishmania major hypothetical protein, conserved 0.0066 0.0495 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Schistosoma mansoni glycogen phosphorylase 0.011 0.1014 0.145
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0066 0.0495 0.0586
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Loa Loa (eye worm) glycogen phosphorylase 0.011 0.1014 0.1647
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus granulosus cytidine deaminase 0.0055 0.0362 0.0365
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0066 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0495 0.0804
Schistosoma mansoni glycogen phosphorylase 0.011 0.1014 0.145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0495 0.4043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0239 0.0389
Loa Loa (eye worm) hypothetical protein 0.0066 0.0495 0.0804
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0495 0.4043
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0274 0.151
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0036 0.0142 0.2878
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0544 0.6154 1
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0352 0.388 0.6217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0239 0.0161
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis cytidine deaminase 0.0055 0.0362 0.0365
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0478 0.537 0.8695
Trypanosoma brucei cytidine deaminase 0.0055 0.0362 0.7309
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0055 0.0362 0.7309
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Brugia malayi carbohydrate phosphorylase 0.011 0.1014 0.1888
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.011 0.1014 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0066 0.0495 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Leishmania major cAMP-specific phosphodiesterase, putative 0.0066 0.0495 1
Echinococcus multilocularis geminin 0.0174 0.1766 0.2702
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0036 0.0142 0.2878
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis cytidine deaminase, putative 0.0055 0.0362 0.2516
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.0274 0.151
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0544 0.6154 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0066 0.0495 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0495 0.4043
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0495 0.4043
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0066 0.0495 1
Onchocerca volvulus 0.0055 0.0362 0.2516
Giardia lamblia Cytidine deaminase 0.0055 0.0362 0.0365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0239 0.0161
Leishmania major hypothetical protein, conserved 0.0066 0.0495 1
Trichomonas vaginalis cytidine deaminase, putative 0.0055 0.0362 0.2516
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0239 0.0161
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0066 0.0495 1
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0495 1
Mycobacterium ulcerans cytidine deaminase 0.0055 0.0362 0.0222
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0495 0.4043
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0478 0.537 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0066 0.0495 0.0804
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0048 0.0274 0.0133
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0066 0.0495 0.0586
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0036 0.0142 0.0231
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0495 1
Entamoeba histolytica glycogen phosphorylase, putative 0.011 0.1014 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0066 0.0495 0.0921
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0495 0.4043
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0478 0.537 0.8726
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0495 0.4043
Echinococcus granulosus geminin 0.0174 0.1766 0.2702

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibitory activity against FabH from Mycobacterium tuberculosis H37Rv at 100 uM ChEMBL. 16392800
Inhibition (binding) Inhibitory activity against KasB from Mycobacterium tuberculosis H37Rv at 100 uM ChEMBL. 16392800
Inhibition (binding) Inhibitory activity against FabH from Escherichia coli ANSI at 100 uM ChEMBL. 16392800
Inhibition (binding) Inhibitory activity against FabB from Escherichia coli ANSI at 100 uM ChEMBL. 16392800
Inhibition (binding) Inhibitory activity against KasA from Mycobacterium tuberculosis H37Rv at 100 uM ChEMBL. 16392800
Inhibition (binding) 0 Inhibitory activity against FabB from Escherichia coli ANSI at 100 uM ChEMBL. 16392800
Inhibition (binding) 0 Inhibitory activity against FabH from Escherichia coli ANSI at 100 uM ChEMBL. 16392800
Inhibition (binding) 0 Inhibitory activity against FabH from Mycobacterium tuberculosis H37Rv at 100 uM ChEMBL. 16392800
Inhibition (binding) 0 Inhibitory activity against KasB from Mycobacterium tuberculosis H37Rv at 100 uM ChEMBL. 16392800
Inhibition (binding) 0 Inhibitory activity against KasA from Mycobacterium tuberculosis H37Rv at 100 uM ChEMBL. 16392800
MIC (functional) > 1000 uM Inhibitory activity against Escherichia coli ANSI ChEMBL. 16392800
MIC (functional) > 1000 uM Inhibitory activity against Mycobacterium tuberculosis H37Rv ChEMBL. 16392800
MIC (functional) > 1000 uM Inhibitory activity against Escherichia coli ANSI ChEMBL. 16392800
MIC (functional) > 1000 uM Inhibitory activity against Mycobacterium tuberculosis H37Rv ChEMBL. 16392800

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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