TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.235 | Formula: C18H15Cl2N3O5
H donors: 1 H acceptors: 4 LogP: 2.49 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COCCOc1cc2ncnc(c2cc1OC)N=C1C=C(O)C(=C(C1=O)Cl)Cl
InChi: 1S/C18H15Cl2N3O5/c1-26-3-4-28-14-7-10-9(5-13(14)27-2)18(22-8-21-10)23-11-6-12(24)15(19)16(20)17(11)25/h5-8,24H,3-4H2,1-2H3/b23-11-
InChiKey: OBINUNHWRUQKOY-KSEXSDGBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0038	0.0108	0.0117
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0072	0.0314	0.0314
Brugia malayi	hypothetical protein	0.0034	0.0083	0.0452
Echinococcus multilocularis	protein patched	0.0042	0.0132	0.0132
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.0726	0.1797
Brugia malayi	photoreceptor-specific nuclear receptor	0.0072	0.0314	0.1709
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0034	0.0083	0.0452
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.0471	0.0471
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0034	0.0083	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Trypanosoma brucei	hypothetical protein, conserved	0.0056	0.0219	0.1286
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0072	0.0314	0.0776
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0072	0.0314	0.1709
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0072	0.0314	0.1709
Brugia malayi	Nuclear hormone receptor E75	0.0034	0.0083	0.0452
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0322	0.1835	1
Schistosoma mansoni	phosphoglucomutase	0.0052	0.0192	0.0209
Brugia malayi	nuclear receptor NHR-67	0.0034	0.0083	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Echinococcus granulosus	replication factor c subunit 1	0.002	0.00000034704	0.00000085853
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0098	0.0535
Echinococcus multilocularis	ecdysone induced protein 78C	0.0072	0.0314	0.0314
Trypanosoma brucei	RNA helicase, putative	0.0299	0.17	1
Brugia malayi	RNase H family protein	0.0052	0.0192	0.1046
Echinococcus granulosus	expressed conserved protein	0.0092	0.0435	0.1077
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0072	0.0314	0.0776
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0072	0.0314	0.1709
Brugia malayi	orphan nuclear receptor NR2E1	0.0034	0.0083	0.0452
Schistosoma mansoni	thyroid hormone receptor	0.0072	0.0314	0.0342
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0049	0.0173	0.7105
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1835	1
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0173	0.0943
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0034	0.0083	0.0452
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0179	0.0967	0.5269
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0034	0.0083	0.0205
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0178	0.097
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0083	0.0452
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0072	0.0314	0.1709
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0173	0.7105
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0072	0.0314	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Schistosoma mansoni	nuclear receptor	0.0034	0.0083	0.009
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0098	0.0535
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0244	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0132	0.072
Trypanosoma brucei	ingi protein (ORF1)	0.0056	0.0219	0.1286
Echinococcus granulosus	thyroid hormone receptor alpha	0.0034	0.0083	0.0205
Brugia malayi	Nuclear hormone receptor-like 1	0.0038	0.0108	0.0587
Brugia malayi	hypothetical protein	0.0038	0.0108	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0034	0.0083	0.0452
Brugia malayi	ecdysone receptor	0.0034	0.0083	0.0452
Onchocerca volvulus		0.0034	0.0083	0.0452
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0072	0.0314	0.1709
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0322	0.1835	1
Trichomonas vaginalis	ribonuclease H1, putative	0.0052	0.0192	1
Onchocerca volvulus		0.0049	0.0173	0.0943
Brugia malayi	Common central domain of tyrosinase family protein	0.0322	0.1835	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0034	0.0083	0.0083
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0072	0.0314	0.1709
Schistosoma mansoni	microtubule-associated protein tau	0.0684	0.4042	0.4405
Onchocerca volvulus		0.0322	0.1835	1
Schistosoma mansoni	zinc finger protein	0.0034	0.0083	0.009
Schistosoma mansoni	tyrosinase precursor	0.1527	0.9177	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Entamoeba histolytica	hypothetical protein	0.0037	0.01	0.2114
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.0726	0.0726
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0049	0.0173	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0072	0.0314	0.0342
Echinococcus granulosus	microtubule associated protein 2	0.0684	0.4042	1
Schistosoma mansoni	hypothetical protein	0.0179	0.097	0.1057
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.0471	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0072	0.0314	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0471	0.2569
Schistosoma mansoni	nuclear hormone receptor	0.0072	0.0314	0.0342
Echinococcus multilocularis	microtubule associated protein 2	0.0684	0.4042	0.4042
Brugia malayi	conserved hypotetical protein	0.0034	0.0083	0.0452
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0072	0.0314	0.0776
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0173	0.7105
Entamoeba histolytica	hypothetical protein	0.0037	0.01	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0189	0.1033
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0034	0.0083	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Schistosoma mansoni	hypothetical protein	0.004	0.0123	0.0134
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0072	0.0314	0.1709
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0034	0.0083	0.0083
Brugia malayi	Nuclear hormone receptor-like 1	0.0072	0.0314	0.1709
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0072	0.0314	0.1709
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.01	0.01
Leishmania major	ribonuclease H1, putative	0.0052	0.0192	0.2673
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0072	0.0314	0.0314
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0072	0.0314	0.0314
Echinococcus multilocularis	ribonuclease H1	0.0052	0.0192	0.0192
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0173	0.0943
Echinococcus granulosus	geminin	0.0179	0.097	0.2399
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0072	0.0314	0.1709
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0098	0.0767
Schistosoma mansoni	RAR-like nuclear receptor	0.0072	0.0314	0.0342
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0072	0.0314	0.1709
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0038	0.0108	0.0108
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0244	0.0265
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0072	0.0314	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0072	0.0314	0.1709
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0049	0.0173	0.7105
Brugia malayi	nuclear receptor NHR-88	0.0072	0.0314	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0034	0.0083	0.0205
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0083	0.009
Brugia malayi	RNase H family protein	0.0052	0.0192	0.1046
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0072	0.0314	0.1709
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.0471	0.2569
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0034	0.0083	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Schistosoma mansoni	thyroid hormone receptor	0.0072	0.0314	0.0342
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0098	0.4033
Loa Loa (eye worm)	ShTK domain-containing protein	0.0322	0.1835	1
Onchocerca volvulus		0.0322	0.1835	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.01	0.0246
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0072	0.0314	0.0342
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0132	0.0327
Brugia malayi	Nuclear hormone receptor E75	0.0034	0.0083	0.0452
Brugia malayi	tailless protein	0.0034	0.0083	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1835	1
Echinococcus granulosus	ribonuclease H1	0.0052	0.0192	0.0475
Schistosoma mansoni	chromosome transmission fidelity factor	0.002	0.00000034704	0.00000037818
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0108	0.0587
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0049	0.0173	0.7105
Trypanosoma cruzi	ribonuclease H1, putative	0.0052	0.0192	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0038	0.0108	0.0266
Brugia malayi	RNase H family protein	0.0052	0.0192	0.1046
Loa Loa (eye worm)	DR-78	0.0034	0.0083	0.0452
Brugia malayi	steroid hormone receptor	0.0072	0.0314	0.1709
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.0471	0.1166
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0072	0.0314	0.0342
Echinococcus granulosus	FTZ F1 alpha	0.0072	0.0314	0.0776
Brugia malayi	hypothetical protein	0.0038	0.0108	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0244	0.0244
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0072	0.0314	0.1709
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0244	1
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0056	0.0219	0.1286
Echinococcus multilocularis	replication factor c subunit 1	0.002	0.00000034704	0.00000034704
Trypanosoma brucei	ingi protein (ORF1)	0.0056	0.0219	0.1286
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0049	0.0173	0.7105
Echinococcus granulosus	ecdysone induced protein 78C	0.0072	0.0314	0.0776
Schistosoma mansoni	coup transcription factor	0.0072	0.0314	0.0342
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0083	0.0451
Brugia malayi	nuclear hormone receptor family member odr-7	0.0034	0.0083	0.0452
Schistosoma mansoni	hypothetical protein	0.0037	0.01	0.0109
Brugia malayi	hypothetical protein	0.0034	0.0083	0.0452
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0052	0.0192	1
Loa Loa (eye worm)	steroid hormone receptor	0.0072	0.0314	0.1709
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0098	1
Giardia lamblia	Ribonuclease H	0.0052	0.0192	1
Trypanosoma brucei	ribonuclease H1	0.0052	0.0192	0.1129
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0132	0.6884
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0049	0.0173	0.552
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0049	0.0173	0.552
Schistosoma mansoni	tyrosinase precursor	0.1527	0.9177	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0451
Schistosoma mansoni	hypothetical protein	0.0299	0.17	0.1852
Brugia malayi	nuclear hormone receptor	0.0034	0.0083	0.0452
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0034	0.0083	0.0083
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.002	0.00000034704	0.0000073629
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0072	0.0314	0.0342
Echinococcus multilocularis	geminin	0.0179	0.097	0.097
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Onchocerca volvulus		0.0322	0.1835	1
Onchocerca volvulus		0.0034	0.0083	0.0452
Toxoplasma gondii	ribonuclease HI protein	0.0052	0.0192	0.7878
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.01	0.0109
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0322	0.1835	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Loa Loa (eye worm)	ShTK domain-containing protein	0.0322	0.1835	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0072	0.0314	0.0314
Onchocerca volvulus	Ribonuclease H1 homolog	0.0052	0.0192	0.1046
Brugia malayi	Nuclear hormone receptor-like 1	0.0038	0.0108	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0098	0.0535
Schistosoma mansoni	hypothetical protein	0.004	0.0123	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0967	0.5269
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0108	0.0587
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0072	0.0314	0.0342
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0173	0.0943
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0173	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0072	0.0314	0.1709
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0244	1
Brugia malayi	nuclear receptor RXR	0.0034	0.0083	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Schistosoma mansoni	nuclear receptor	0.0034	0.0083	0.009
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0049	0.0173	0.3672
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0098	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0244	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0049	0.0173	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0178	0.097
Onchocerca volvulus	Bile acid receptor homolog	0.0072	0.0314	0.1709
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0072	0.0314	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0452
Onchocerca volvulus	Protein ultraspiracle homolog	0.0072	0.0314	0.1709
Onchocerca volvulus		0.0072	0.0314	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0038	0.0108	0.0117
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.1709
Schistosoma mansoni	hypothetical protein	0.004	0.0123	0.0134
Entamoeba histolytica	hypothetical protein	0.0037	0.01	0.2114
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0132	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0108	0.0587
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0072	0.0314	0.1709
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0322	0.1835	1
Brugia malayi	CHE-14 protein	0.0042	0.0132	0.072
Brugia malayi	nuclear receptor RXR	0.0038	0.0108	0.0587
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0083	0.0205
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0072	0.0314	0.1709
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0244	0.0603
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0481	0.0524
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0072	0.0314	0.1709
Brugia malayi	ShTK domain containing protein	0.0322	0.1835	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0072	0.0314	0.1709
Brugia malayi	N-terminal motif family protein	0.0179	0.0967	0.5269
Onchocerca volvulus		0.0322	0.1835	1
Trypanosoma cruzi	ribonuclease H1, putative	0.0052	0.0192	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0132	0.072
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0038	0.0108	0.0587
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0072	0.0314	0.0314
Entamoeba histolytica	acyl-coA synthetase, putative	0.0049	0.0173	0.3672
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0034	0.0083	0.009
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0244	1
Trypanosoma brucei	unspecified product	0.0056	0.0219	0.1286
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0435	0.0435
Echinococcus multilocularis	FTZ F1 alpha	0.0072	0.0314	0.0314
Mycobacterium ulcerans	hypothetical protein	0.0049	0.0173	0.7105
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0173	0.0943
Schistosoma mansoni	hypothetical protein	0.004	0.0123	0.0134
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0244	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0034	0.0083	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0178	0.097
Loa Loa (eye worm)	tyrosinase 1	0.0322	0.1835	1
Treponema pallidum	ribonuclease H (rnhA)	0.0052	0.0192	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0034	0.0083	0.0205
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0049	0.0173	0.3672
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0072	0.0314	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0108	0.0587
Schistosoma mansoni	phosphoglucomutase	0.0052	0.0192	0.0209
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0178	0.097
Brugia malayi	ecdysteroid receptor	0.0072	0.0314	0.1709
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0034	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0098	0.0535
Entamoeba histolytica	hypothetical protein	0.0037	0.01	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0108	0.0587
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0072	0.0314	0.0342
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0072	0.0314	0.0314
Schistosoma mansoni	nuclear receptor nhr-48	0.0034	0.0083	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0072	0.0314	0.1709
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0034	0.0083	0.0083
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0173	0.7105
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0244	0.0265
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0072	0.0314	0.0342
Brugia malayi	hypothetical protein	0.0037	0.01	0.0543
Schistosoma mansoni	hypothetical protein	0.0179	0.097	0.1057
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0168	0.0168
Brugia malayi	Steroid receptor seven-up type 2	0.0072	0.0314	0.1709
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0072	0.0314	0.0342
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0072	0.0314	0.0776
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0034	0.0083	0.009
Schistosoma mansoni	patched 1	0.0042	0.0132	0.0144
Schistosoma mansoni	phosphoglucomutase	0.0052	0.0192	0.0209
Schistosoma mansoni	hypothetical protein	0.0034	0.0083	0.009
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0072	0.0314	0.0776
Brugia malayi	nuclear hormone receptor	0.0072	0.0314	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0098	0.0535
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0132	0.0132
Loa Loa (eye worm)	nuclear hormone receptor	0.0034	0.0083	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0173	0.0943

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13.5 nM	Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP	ChEMBL.	16302797

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 432367

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 348402