Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | UDP-N-acetylmuramate:L-alanine ligase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium leprae | Probable UDP-N-acetylmuramate-alanine ligase MurC | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Mycobacterium tuberculosis | Probable UDP-N-acetylmuramate-alanine ligase MurC | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramate-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Chlamydia trachomatis | bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Mycobacterium ulcerans | UDP-N-acetylmuramate--L-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Treponema pallidum | UDP-N-acetylmuramate--L-alanine ligase | Get druggable targets OG5_132146 | All targets in OG5_132146 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0347 | 0.2024 |
Brugia malayi | AMP-binding enzyme family protein | 0.0079 | 0.0347 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1524 | 1 |
Chlamydia trachomatis | bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase | 0.0404 | 0.5227 | 1 |
Chlamydia trachomatis | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase | 0.0096 | 0.0605 | 0.1075 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0079 | 0.0347 | 0.1442 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0096 | 0.0605 | 0.1075 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0079 | 0.0347 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0079 | 0.0347 | 0.0577 |
Mycobacterium leprae | ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.0188 | 0.1986 | 0.7962 |
Treponema pallidum | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) | 0.0188 | 0.1986 | 0.2989 |
Brugia malayi | AMP-binding enzyme family protein | 0.0079 | 0.0347 | 0.0603 |
Brugia malayi | hypothetical protein | 0.0157 | 0.1524 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0272 | 0.1513 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0347 | 0.2024 |
Mycobacterium ulcerans | UDP-N-acetylmuramate--L-alanine ligase | 0.0404 | 0.5227 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramyl pentapeptide synthase | 0.0188 | 0.1986 | 0.2989 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.1029 | 0.6046 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0079 | 0.0347 | 0.5 |
Chlamydia trachomatis | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 0.0096 | 0.0605 | 0.1075 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0079 | 0.0347 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0079 | 0.0347 | 0.0577 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0079 | 0.0347 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0347 | 0.2024 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0272 | 0.1513 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.1029 | 0.6645 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0096 | 0.0605 | 0.2513 |
Mycobacterium ulcerans | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.0188 | 0.1986 | 0.3742 |
Onchocerca volvulus | 0.0157 | 0.1524 | 1 | |
Onchocerca volvulus | 0.0106 | 0.0751 | 0.3432 | |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0059 | 0.0048 | 0.02 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0079 | 0.0347 | 0.0577 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0079 | 0.0347 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0079 | 0.0347 | 0.1442 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0079 | 0.0347 | 0.0577 |
Mycobacterium tuberculosis | Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF | 0.0188 | 0.1986 | 0.8256 |
Chlamydia trachomatis | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminoligase | 0.0188 | 0.1986 | 0.3742 |
Mycobacterium ulcerans | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase | 0.0188 | 0.1986 | 0.3742 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0106 | 0.0751 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0096 | 0.0605 | 0.1252 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0079 | 0.0347 | 0.0577 |
Mycobacterium tuberculosis | Probable UDP-N-acetylmuramate-alanine ligase MurC | 0.0216 | 0.2406 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0079 | 0.0347 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0079 | 0.0347 | 0.5 |
Mycobacterium ulcerans | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | 0.0096 | 0.0605 | 0.1075 |
Treponema pallidum | UDP-N-acetylmuramate--L-alanine ligase | 0.0404 | 0.5227 | 1 |
Treponema pallidum | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) | 0.0188 | 0.1986 | 0.2989 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.1029 | 0.6645 |
Echinococcus multilocularis | tumor protein p63 | 0.0722 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0079 | 0.0347 | 0.0577 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0059 | 0.0048 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0272 | 0.1513 |
Mycobacterium leprae | Probable UDP-N-acetylmuramate-alanine ligase MurC | 0.0216 | 0.2406 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.0347 | 0.0577 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0059 | 0.0048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0751 | 0.4762 |
Brugia malayi | AMP-binding enzyme family protein | 0.0079 | 0.0347 | 0.0603 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylmuramate-alanine ligase | 0.0404 | 0.5227 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 ug ml-1 | Inhibitory activity against MurC in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | = 10 ug ml-1 | Inhibitory activity against MurC in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurB in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurA in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurD in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurB in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurA in Escherichia coli | ChEMBL. | 16216496 |
IC50 (binding) | > 25 ug ml-1 | Inhibitory activity against MurD in Escherichia coli | ChEMBL. | 16216496 |
MIC (functional) | <= 0.12 ug ml-1 | Antibacterial activity against pencillin resistant Streptococcus pneumoniae | ChEMBL. | 16216496 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against methicillin resistant Staphylococcus aureus | ChEMBL. | 16216496 |
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against vancomycin resistant Enterococcus faecalis | ChEMBL. | 16216496 |
MIC (functional) | = 64 ug ml-1 | Antibacterial activity against Enterococcus faecalis | ChEMBL. | 16216496 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Staphylococcus aureus | ChEMBL. | 16216496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.