Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0064 | 0.0762 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0024 | 0.0044 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0518 | 0.1605 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.1225 | 0.3797 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0093 | 0.1113 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0109 | 0.1145 | 0.3548 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.2252 | 0.2255 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0165 | 0.1875 | 0.1878 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0093 | 0.1113 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.1525 | 0.6613 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0076 | 0.0721 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0007 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.0427 | 0.185 |
Echinococcus multilocularis | expressed conserved protein | 0.0108 | 0.1135 | 0.1135 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0165 | 0.0717 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0792 | 0.9987 | 0.9987 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0093 | 0.1113 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0085 | 0.0837 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0115 | 0.1225 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0085 | 0.0837 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0085 | 0.0837 | 0.0838 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0264 | 0.3143 | 0.3143 |
Brugia malayi | Inositol-1 | 0.0085 | 0.0837 | 0.3629 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0165 | 0.0166 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0093 | 0.1291 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0374 | 0.4011 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0007 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.0064 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0093 | 0.1291 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.2252 | 0.2255 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0165 | 0.1865 | 0.1865 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2307 | 0.7149 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0792 | 0.9987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.3227 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0049 | 0.0374 | 0.0374 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0064 | 0.0762 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0093 | 0.1113 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.0064 | 0.0276 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0085 | 0.0837 | 0.6658 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0279 | 0.1853 |
Brugia malayi | CHE-14 protein | 0.0049 | 0.0374 | 0.1621 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0007 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.0837 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0093 | 0.1113 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0351 | 0.0351 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.0064 | 0.0064 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0064 | 0.0762 |
Echinococcus granulosus | expressed conserved protein | 0.0108 | 0.1135 | 0.1136 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0279 | 0.0279 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0427 | 0.0427 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0792 | 0.9987 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0085 | 0.0837 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0374 | 0.1159 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.1525 | 0.4728 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0117 | 0.1248 | 0.125 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.0837 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0365 | 0.1132 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0115 | 0.1225 | 0.1227 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0085 | 0.0837 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0049 | 0.0374 | 0.0374 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0085 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.1525 | 0.4728 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.0064 | 1 |
Echinococcus multilocularis | protein patched | 0.0049 | 0.0374 | 0.0374 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0049 | 0.0374 | 0.1159 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0427 | 0.0427 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0427 | 0.0427 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0021 | 0.0002 | 0.0028 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2916 | 0.9038 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0085 | 0.0837 | 0.0838 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0279 | 0.1853 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0093 | 0.0253 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0427 | 0.0427 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0365 | 0.1583 |
Loa Loa (eye worm) | inositol-1 | 0.0085 | 0.0837 | 0.2594 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0165 | 0.1875 | 0.1875 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0093 | 0.0404 |
Onchocerca volvulus | 0.0028 | 0.0093 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0199 | 0.2307 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0056 | 0.0464 | 0.0464 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0279 | 0.0279 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0093 | 0.0404 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0093 | 0.1113 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0351 | 0.0351 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.0837 | 1 |
Schistosoma mansoni | patched 1 | 0.0049 | 0.0374 | 0.0374 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0002 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0351 | 0.0351 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0093 | 0.0253 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0093 | 0.1113 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0085 | 0.0837 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0076 | 0.0721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0289 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0165 | 0.1865 | 0.1867 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0007 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0093 | 0.1291 |
Brugia malayi | Cytochrome P450 family protein | 0.0109 | 0.1145 | 0.4964 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0427 | 0.0427 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0049 | 0.0374 | 0.0374 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0279 | 0.1853 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0165 | 0.0513 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0093 | 0.1113 |
Echinococcus granulosus | geminin | 0.0195 | 0.2252 | 0.2255 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0427 | 0.0427 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0085 | 0.0837 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0093 | 0.0404 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0093 | 0.1113 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0173 | 0.1968 | 0.1971 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0115 | 0.1225 | 0.1225 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0024 | 0.0044 | 0.0615 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0093 | 0.1113 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0351 | 0.0351 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0427 | 0.0427 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0093 | 0.1291 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.0064 | 0.0762 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0289 |
Schistosoma mansoni | inositol monophosphatase | 0.0085 | 0.0837 | 0.0838 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.0427 | 0.1323 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0115 | 0.1225 | 0.5311 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0279 | 0.1209 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.0064 | 0.5 |
Echinococcus multilocularis | geminin | 0.0195 | 0.2252 | 0.2252 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0007 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0093 | 0.0253 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.0064 | 0.0198 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0002 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.2051 | 0.6358 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.0837 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0093 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0093 | 0.0289 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0279 | 0.1853 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC30 (binding) | = 0.49 uM | Inhibitory activity against Sodium/Calcium exchanger in isolated guinea pig left atria | ChEMBL. | 16249082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.