Detailed information for compound 352101

Basic information

Technical information
  • TDR Targets ID: 352101
  • Name: (1R,2R)-N-(cyanomethyl)-2-[(4-methylsulfanylp henyl)sulfonylmethyl]cyclohexane-1-carboxamid e
  • MW: 366.498 | Formula: C17H22N2O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)[C@@H]1CCCC[C@H]1CS(=O)(=O)c1ccc(cc1)SC
  • InChi: 1S/C17H22N2O3S2/c1-23-14-6-8-15(9-7-14)24(21,22)12-13-4-2-3-5-16(13)17(20)19-11-10-18/h6-9,13,16H,2-5,11-12H2,1H3,(H,19,20)/t13-,16+/m0/s1
  • InChiKey: CFBDLITUAFRXGT-XJKSGUPXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R,2R)-N-(cyanomethyl)-2-[(4-methylsulfanylphenyl)sulfonylmethyl]cyclohexanecarboxamide
  • (1R,2R)-N-(cyanomethyl)-2-[[4-(methylthio)phenyl]sulfonylmethyl]cyclohexanecarboxamide
  • (1R,2R)-N-(cyanomethyl)-2-[[4-(methylthio)phenyl]sulfonylmethyl]-1-cyclohexanecarboxamide
  • (1R,2R)-N-(cyanomethyl)-2-[[4-(methylthio)phenyl]sulfonylmethyl]cyclohexane-1-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0539 0.066
Schistosoma mansoni neuropeptide F-like receptor 0.0138 0.5102 0.5102
Echinococcus granulosus fmrfamide receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Brugia malayi Cathepsin L-like precursor 0.0027 0.0539 0.066
Loa Loa (eye worm) hypothetical protein 0.0256 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0138 0.5102 0.5102
Schistosoma mansoni opsin-like receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis G protein coupled receptor 139 0.0138 0.5102 0.5102
Echinococcus multilocularis orexin receptor type 2 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0083 0.2859 0.3499
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Onchocerca volvulus 0.0027 0.0539 0.0459
Schistosoma mansoni neuropeptide receptor 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0138 0.5102 0.6164
Loa Loa (eye worm) thymidylate kinase 0.0212 0.817 0.8138
Echinococcus granulosus neuropeptides capa receptor 0.0138 0.5102 0.5102
Schistosoma mansoni adenoreceptor 0.0138 0.5102 0.5102
Schistosoma mansoni biogenic amine receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0138 0.5102 0.6164
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0138 0.5102 0.5102
Plasmodium vivax vivapain-2 0.0027 0.0539 0.066
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0138 0.5102 0.6164
Onchocerca volvulus 0.0027 0.0539 0.0459
Echinococcus multilocularis cysteine protease 0.0027 0.0539 0.0539
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis neuropeptides capa receptor 0.0138 0.5102 0.5102
Brugia malayi ORL1-like opioid receptor 0.0138 0.5102 0.6244
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Echinococcus multilocularis somatostatin receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus granulosus g protein coupled receptor 0.0138 0.5102 0.5102
Echinococcus granulosus g protein coupled receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0138 0.5102 0.5102
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0138 0.5102 0.5016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Schistosoma mansoni myosin xvIII 0.0138 0.5102 0.5102
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0539 0.0459
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0539 0.066
Schistosoma mansoni neuropeptide receptor 0.0138 0.5102 0.5102
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0539 0.066
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0138 0.5102 0.5102
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Schistosoma mansoni growth hormone secretagogue receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus granulosus neuropeptide receptor 0.0138 0.5102 0.5102
Brugia malayi sulfakinin receptor protein 0.0138 0.5102 0.6244
Echinococcus multilocularis sex peptide receptor 0.0138 0.5102 0.5102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0171 0.021
Brugia malayi Cathepsin L-like precursor 0.0027 0.0539 0.066
Schistosoma mansoni amine GPCR 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0138 0.5102 0.5102
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0539 0.0459
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0138 0.5102 0.6244
Echinococcus granulosus neuropeptides capa receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0256 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0138 0.5102 0.5102
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0171 0.021
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0539 0.066
Echinococcus multilocularis serotonin receptor 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Echinococcus granulosus cathepsin l1 0.0018 0.0171 0.0171
Echinococcus granulosus neuropeptide s receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) TYRA-2 protein 0.0138 0.5102 0.5016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) fibroinase 0.0027 0.0539 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0138 0.5102 0.5102
Schistosoma mansoni amine GPCR 0.0138 0.5102 0.5102
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0539 0.066
Trichomonas vaginalis thymidylate kinase, putative 0.0212 0.817 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0138 0.5102 0.5102
Echinococcus granulosus tachykinin peptides receptor 99D 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0138 0.5102 0.6244
Brugia malayi Tachykinin-like peptides receptor 99D 0.0138 0.5102 0.6244
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0138 0.5102 0.5102
Schistosoma mansoni hypothetical protein 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0027 0.0539 0.0459
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus granulosus neuropeptide Y receptor 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0138 0.5102 0.5016
Onchocerca volvulus 0.0138 0.5102 0.6164
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis neuropeptide Y receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0138 0.5102 0.5016
Echinococcus multilocularis fmrfamide receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis neuropeptide FF receptor 2 0.0138 0.5102 0.5102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Echinococcus granulosus sex peptide receptor 0.0138 0.5102 0.5102
Echinococcus granulosus rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0138 0.5102 0.5102
Echinococcus granulosus orexin receptor type 2 0.0138 0.5102 0.5102
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0138 0.5102 0.6164
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Schistosoma mansoni neuropeptide receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Schistosoma mansoni hypothetical protein 0.0138 0.5102 0.5102
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0539 0.066
Brugia malayi Dopamine receptor protein 1 0.0138 0.5102 0.6244
Echinococcus granulosus G protein coupled receptor 139 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus granulosus dro:myosuppressin receptor 0.0138 0.5102 0.5102
Brugia malayi neuropeptide F receptor 0.0138 0.5102 0.6244
Schistosoma mansoni neuropeptide receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) neuropeptide F receptor 0.0138 0.5102 0.5016
Schistosoma mansoni histamine h1 receptor 0.0138 0.5102 0.5102
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Loa Loa (eye worm) G-protein coupled receptor 0.0138 0.5102 0.5016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0138 0.5102 0.5102
Schistosoma mansoni hypothetical protein 0.0138 0.5102 0.5102
Echinococcus granulosus tm gpcr rhodopsin 0.0138 0.5102 0.5102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0138 0.5102 0.6244
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Brugia malayi cathepsin L-like precursor 0.0018 0.0171 0.021
Brugia malayi G-protein coupled receptor 0.0138 0.5102 0.6244
Echinococcus granulosus neuropeptide Y receptor 0.0138 0.5102 0.5102
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0171 0.021
Echinococcus multilocularis neuropeptide s receptor 0.0138 0.5102 0.5102
Echinococcus granulosus tm gpcr rhodopsin 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0138 0.5102 0.6164
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0171 0.021
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Echinococcus granulosus hypothetical protein 0.0138 0.5102 0.5102
Chlamydia trachomatis thymidylate kinase 0.0212 0.817 0.5
Onchocerca volvulus 0.0138 0.5102 0.6164
Onchocerca volvulus 0.0138 0.5102 0.6164
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0539 0.066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0539 0.066
Trypanosoma brucei thymidylate kinase, putative 0.0212 0.817 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0138 0.5102 0.5102
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0539 0.0374
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0539 0.0539
Schistosoma mansoni amine GPCR 0.0138 0.5102 0.5102
Onchocerca volvulus Neuropeptide F receptor homolog 0.0138 0.5102 0.6164
Brugia malayi Cathepsin L-like precursor 0.0027 0.0539 0.066
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) G-protein coupled receptor 0.0138 0.5102 0.5016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Brugia malayi follicle stimulating hormone receptor 0.0138 0.5102 0.6244
Echinococcus granulosus neuropeptide receptor A26 0.0138 0.5102 0.5102
Schistosoma mansoni amine GPCR 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0539 0.066
Echinococcus multilocularis g protein coupled receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus granulosus rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Onchocerca volvulus 0.0138 0.5102 0.6164
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Schistosoma mansoni biogenic amine receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0138 0.5102 0.5102
Brugia malayi G protein-coupled receptor 0.0138 0.5102 0.6244
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0138 0.5102 0.5102
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0138 0.5102 0.5102
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0212 0.817 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0171 0.021
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0138 0.5102 0.5016
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0027 0.0539 0.0459
Onchocerca volvulus Putative thymidylate kinase 0.0212 0.817 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) cysteine protease 0.0027 0.0539 0.0374
Onchocerca volvulus 0.0138 0.5102 0.6164
Schistosoma mansoni thymidylate kinase 0.0212 0.817 0.817
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0539 0.0539
Echinococcus granulosus rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) ctsf protein 0.0027 0.0539 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0539 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Trypanosoma brucei thymidylate kinase, putative 0.0212 0.817 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Schistosoma mansoni opsin-like receptor 0.0138 0.5102 0.5102
Brugia malayi putative neuropeptide receptor NPR1 0.0138 0.5102 0.6244
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0539 0.0459
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0212 0.817 0.5
Echinococcus granulosus thymidylate kinase 0.0212 0.817 0.817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Brugia malayi GnHR receptor homolog 0.0138 0.5102 0.6244
Schistosoma mansoni alpha-1 adrenergic receptor 0.0138 0.5102 0.5102
Schistosoma mansoni neuropeptide F-like receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Echinococcus multilocularis thymidylate kinase 0.0212 0.817 0.817
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0539 0.066
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0539 0.0539
Plasmodium vivax vivapain-2 0.0027 0.0539 0.066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0138 0.5102 0.6244
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0138 0.5102 0.5102
Schistosoma mansoni biogenic amine (5HT) receptor 0.0256 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0138 0.5102 0.5102
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0027 0.0539 0.0459
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Treponema pallidum thymidylate kinase (tmk) 0.0212 0.817 0.5
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Leishmania major thymidylate kinase-like protein 0.0212 0.817 1
Brugia malayi Dopamine receptor 0.0138 0.5102 0.6244
Toxoplasma gondii thymidylate kinase 0.0212 0.817 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis neuropeptide receptor 0.0138 0.5102 0.5102
Echinococcus granulosus rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Echinococcus granulosus allatostatin A receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0539 0.0374
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis serotonin receptor 0.0256 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0539 0.0539
Onchocerca volvulus 0.0027 0.0539 0.0459
Echinococcus multilocularis fmrfamide receptor 0.0138 0.5102 0.5102
Schistosoma mansoni opsin-like receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0138 0.5102 0.5102
Echinococcus granulosus g-protein coupled receptor 0.0138 0.5102 0.5102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Brugia malayi Cathepsin L-like precursor 0.0018 0.0171 0.021
Echinococcus granulosus rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Echinococcus multilocularis g-protein coupled receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis neuropeptide Y receptor 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0138 0.5102 0.6164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Entamoeba histolytica Thymidylate kinase, putative 0.0212 0.817 1
Onchocerca volvulus 0.0138 0.5102 0.6164
Onchocerca volvulus 0.0027 0.0539 0.0459
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Brugia malayi Cathepsin L-like precursor 0.0027 0.0539 0.066
Echinococcus granulosus rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Schistosoma mansoni thymidylate kinase 0.0212 0.817 0.817
Echinococcus granulosus serotonin receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis allatostatin A receptor 0.0138 0.5102 0.5102
Schistosoma mansoni hypothetical protein 0.0212 0.817 0.817
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0539 0.066
Echinococcus granulosus neuropeptide receptor 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Brugia malayi putative neuropeptide receptor 0.0138 0.5102 0.6244
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0138 0.5102 0.5016
Brugia malayi larval opioid receptor 0.0138 0.5102 0.6244
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0138 0.5102 0.5102
Brugia malayi Cathepsin L-like precursor 0.0018 0.0171 0.021
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0539 0.0539
Trichomonas vaginalis thymidylate kinase, putative 0.0212 0.817 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0138 0.5102 0.6244
Brugia malayi Serotonin receptor 0.0138 0.5102 0.6244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0138 0.5102 0.5102
Echinococcus multilocularis neuropeptide receptor A26 0.0138 0.5102 0.5102
Echinococcus granulosus somatostatin receptor 0.0138 0.5102 0.5102
Trypanosoma cruzi thymidylate kinase, putative 0.0212 0.817 1
Schistosoma mansoni amine GPCR 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0539 0.066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0539 0.066
Plasmodium vivax thymidylate kinase, putative 0.0212 0.817 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0539 0.066
Schistosoma mansoni neuropeptide f receptor 76f 0.0138 0.5102 0.5102
Brugia malayi neuropeptide F receptor 0.0138 0.5102 0.6244
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0138 0.5102 0.6164
Mycobacterium ulcerans thymidylate kinase 0.0212 0.817 0.5
Schistosoma mansoni hypothetical protein 0.0138 0.5102 0.5102
Onchocerca volvulus 0.0138 0.5102 0.6164
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0539 0.0539
Echinococcus multilocularis neuropeptides capa receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis g protein coupled receptor 0.0138 0.5102 0.5102
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus multilocularis neuropeptide receptor 0.0138 0.5102 0.5102
Brugia malayi G-protein coupled receptor 0.0138 0.5102 0.6244
Onchocerca volvulus 0.0138 0.5102 0.6164
Brugia malayi Cathepsin L-like precursor 0.0027 0.0539 0.066
Brugia malayi RE15519p 0.0138 0.5102 0.6244
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Echinococcus granulosus cathepsin l1 0.0027 0.0539 0.0539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Echinococcus granulosus g protein coupled receptor 0.0138 0.5102 0.5102
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0138 0.5102 0.5102
Trypanosoma cruzi thymidylate kinase, putative 0.0212 0.817 1
Onchocerca volvulus 0.0138 0.5102 0.6164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Onchocerca volvulus 0.0138 0.5102 0.6164
Onchocerca volvulus 0.0138 0.5102 0.6164
Giardia lamblia CDC8 0.0212 0.817 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0138 0.5102 0.5102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0138 0.5102 0.5102
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0171 0.0171
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0138 0.5102 0.6244
Brugia malayi thymidylate kinase 0.0212 0.817 1
Brugia malayi Dopamine receptor protein 2 0.0138 0.5102 0.6244
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Leishmania major hypothetical protein, conserved 0.0083 0.2859 0.304
Loa Loa (eye worm) neuropeptide F receptor 0.0138 0.5102 0.5016
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0212 0.817 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0138 0.5102 0.5102
Brugia malayi Serotonin receptor 0.0138 0.5102 0.6244
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0138 0.5102 0.5102
Echinococcus multilocularis cysteine protease 0.0027 0.0539 0.0539
Brugia malayi Melatonin receptor type 1A 0.0138 0.5102 0.6244
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0138 0.5102 0.5102
Brugia malayi Cathepsin L-like precursor 0.0027 0.0539 0.066
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0539 0.066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0539 0.066
Brugia malayi AKH receptor 0.0138 0.5102 0.6244
Loa Loa (eye worm) hypothetical protein 0.0138 0.5102 0.5016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0138 0.5102 0.5102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0138 0.5102 0.5102
Echinococcus granulosus alpha 1A adrenergic receptor 0.0138 0.5102 0.5102
Echinococcus multilocularis g protein coupled receptor 0.0138 0.5102 0.5102
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0539 0.0539
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0539 0.0539
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Brugia malayi hypothetical protein 0.0138 0.5102 0.6244
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0083 0.2859 0.3499
Plasmodium falciparum thymidylate kinase 0.0212 0.817 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0138 0.5102 0.5016
Schistosoma mansoni biogenic amine receptor 0.0138 0.5102 0.5102
Entamoeba histolytica cysteine protease, putative 0.0027 0.0539 0.066

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 38 ml/min.kg Plasma clearance in rat at 10 mL/kg, iv ChEMBL. 16451072
IC50 (binding) = 5 nM Inhibitory activity against humanized rabbit Cathepsin K ChEMBL. 16451072
IC50 (binding) = 5 nM Inhibitory activity against humanized rabbit Cathepsin K ChEMBL. 16451072
Selectivity ratio (binding) = 740 Selectivity for Cathepsin L over Cathepsin K ChEMBL. 16451072
Selectivity ratio (binding) = 1800 Selectivity for Cathepsin S over Cathepsin K ChEMBL. 16451072
Selectivity ratio (binding) = 2000 Selectivity for Cathepsin B over Cathepsin K ChEMBL. 16451072
T1/2 (ADMET) = 5 min Half life in rat at 10 mL/kg, iv ChEMBL. 16451072

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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