Detailed information for compound 354313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.461 | Formula: C17H32N4O3
  • H donors: 2 H acceptors: 2 LogP: 2.93 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@H](NC(=O)OC(C)(C)C)/C=N/NC(=O)N1CCCCC1
  • InChi: 1S/C17H32N4O3/c1-5-6-10-14(19-16(23)24-17(2,3)4)13-18-20-15(22)21-11-8-7-9-12-21/h13-14H,5-12H2,1-4H3,(H,19,23)(H,20,22)/b18-13+/t14-/m0/s1
  • InChiKey: VAWNOLXSSUCWHC-RAOBZKRQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0147 0.235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0147 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Brugia malayi isocitrate dehydrogenase 0.0018 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0057 0.0627 1
Echinococcus granulosus cathepsin l1 0.0018 0.0003 0.0005
Plasmodium vivax vivapain-2 0.0027 0.0147 0.0583
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0 0.0001
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0147 0.0145
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0627 1
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0 0.5
Leishmania major telomerase reverse transcriptase, putative 0.0173 0.252 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.039 0.0658
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.039 0.0658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Echinococcus multilocularis cysteine protease 0.0027 0.0147 0.0249
Loa Loa (eye worm) ctsf protein 0.0027 0.0147 0.235
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0147 0.0249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0147 0.0583
Onchocerca volvulus 0.0027 0.0147 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Toxoplasma gondii RNA-directed DNA polymerase 0.0173 0.252 1
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.039 0.0658
Brugia malayi Cathepsin L-like precursor 0.0027 0.0147 0.0205
Entamoeba histolytica cysteine protease, putative 0.0027 0.0147 0.3733
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0 0.0001
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.062 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.039 0.0658
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0043
Onchocerca volvulus 0.0027 0.0147 0.0145
Brugia malayi Cathepsin L-like precursor 0.0027 0.0147 0.0205
Plasmodium vivax telomerase reverse transcriptase, putative 0.0173 0.252 1
Plasmodium falciparum telomerase reverse transcriptase 0.0173 0.252 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0004
Leishmania major cysteine peptidase A (CPA) 0.0027 0.0147 0.0583
Giardia lamblia Telomerase catalytic subunit 0.0173 0.252 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.039 0.0658
Loa Loa (eye worm) hypothetical protein 0.0042 0.039 0.6223
Plasmodium vivax vivapain-2 0.0027 0.0147 0.0583
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0173 0.252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0003 0.0004
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0147 0.0583
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0003 0.0043
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.039 0.6296
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0173 0.252 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0147 0.3733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Loa Loa (eye worm) hypothetical protein 0.0056 0.062 0.9884
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0147 0.3733
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0147 0.235
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Echinococcus multilocularis cysteine protease 0.0027 0.0147 0.0249
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0147 0.0583
Brugia malayi Cathepsin L-like precursor 0.0027 0.0147 0.0205
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Loa Loa (eye worm) fibroinase 0.0027 0.0147 0.235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Brugia malayi Cathepsin L-like precursor 0.0027 0.0147 0.0205
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Onchocerca volvulus 0.0027 0.0147 0.0145
Schistosoma mansoni hypothetical protein 0.0039 0.0337 0.5434
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.039 0.0543
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0147 0.0249
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0147 0.0249
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.039 0.1548
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0147 0.0249
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0147 0.2377
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.039 0.1548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.039 0.1548
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0147 0.0249
Loa Loa (eye worm) cysteine protease 0.0027 0.0147 0.235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0627 0.0873
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.039 0.1548
Brugia malayi Cathepsin L-like precursor 0.0027 0.0147 0.0205
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0147 0.3733
Brugia malayi Cathepsin L-like precursor 0.0027 0.0147 0.0205
Onchocerca volvulus 0.0027 0.0147 0.0145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0147 0.2377
Onchocerca volvulus 0.0056 0.062 0.0618
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0147 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0147 0.0583
Brugia malayi cathepsin L-like precursor 0.0018 0.0003 0.0004
Trypanosoma brucei telomerase reverse transcriptase 0.0173 0.252 1
Echinococcus granulosus tumor protein p63 0.0383 0.5931 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.039 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0337 0.5371
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.039 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0147 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0043
Toxoplasma gondii cathepsin CPL 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0147 0.3733
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0627 0.0873
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.039 0.0658
Echinococcus multilocularis tumor protein p63 0.0383 0.5931 1
Brugia malayi Telomerase reverse transcriptase 0.0461 0.7189 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0147 0.0249
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0 0.0001
Onchocerca volvulus 0.0027 0.0147 0.0145
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0147 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0147 0.0583
Onchocerca volvulus 0.0027 0.0147 0.0145
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0337 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.039 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0147 0.3733
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0147 0.3733
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0147 0.0583
Onchocerca volvulus 0.0027 0.0147 0.0145
Echinococcus granulosus cathepsin l1 0.0027 0.0147 0.0249
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.039 0.6296
Brugia malayi Isocitrate dehydrogenase 0.0018 0 0.0001
Leishmania major cathepsin L-like protease 0.0027 0.0147 0.0583
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 58 nM Inhibition of recombinant human cathepsin K in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 58 nM Inhibition of recombinant human cathepsin K in a fluorescence assay ChEMBL. 16290936

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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