TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 218.212 | Formula: C10H10N4O2
H donors: 1 H acceptors: 3 LogP: 0.08 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: [O-][n+]1c(NC2CC2)n[n+](c2c1cccc2)[O-]
InChi: 1S/C10H10N4O2/c15-13-8-3-1-2-4-9(8)14(16)12-10(13)11-7-5-6-7/h1-4,7H,5-6H2,(H,11,12)
InChiKey: MBZHDHBBJKNQOK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Leishmania major	P-type ATPase, putative	0.0031	0.0065	0.0209
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0026	0.0032	0.0032
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0001	0.0001
Toxoplasma gondii	diacylglycerol acyltransferase	0.0072	0.0359	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus multilocularis	nervana 2	0.0058	0.0257	0.0442
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0001	0.0001
Brugia malayi	G-protein coupled receptor	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Onchocerca volvulus		0.0325	0.2162	1
Leishmania major	diacylglycerol acyltransferase, putative	0.0072	0.0359	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0072	0.0359	0.1658
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0359	1
Echinococcus multilocularis	nervana 2	0.0058	0.0257	0.0442
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0038	0.0119	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0001	0.0001
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0001	0.0001
Onchocerca volvulus		0.0058	0.0257	0.1185
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0038	0.0119	1
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0038	0.0119	0.0204
Brugia malayi	G-protein coupled receptor	0.0022	0.0001	0.0001
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0058	0.0257	0.0442
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.1423	1	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0058	0.0257	0.0442
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0072	0.0359	0.1584
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0038	0.0119	1
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0038	0.0119	0.2672
Echinococcus granulosus	tm gpcr rhodopsin	0.0834	0.5797	1
Echinococcus granulosus	nervana 2	0.0058	0.0257	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0257	0.0257
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0031	0.0065	0.011
Plasmodium vivax	calcium-transporting ATPase, putative	0.0038	0.0119	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Toxoplasma gondii	dgat2l1-prov protein	0.0325	0.2162	1
Echinococcus granulosus	calcium transporting atpase	0.0031	0.0065	0.011
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0031	0.0065	0.0209
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0072	0.0359	0.1584
Brugia malayi	neuropeptide F receptor	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0834	0.5797	1
Plasmodium vivax	P-type ATPase4, putative	0.0038	0.0119	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0001	0.0001
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0001	0.0001
Leishmania major	diacylglycerol acyltransferase, putative	0.0325	0.2162	1
Loa Loa (eye worm)	hypothetical protein	0.1423	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0001	0.0001
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0031	0.0065	0.0295
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0031	0.0065	0.0295
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0031	0.0065	0.4509
Echinococcus granulosus	nervana 2	0.0058	0.0257	0.0442
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0031	0.0065	0.011
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0001	0.0001
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0038	0.0119	1
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0038	0.0119	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	E1-E2 ATPase	0.0024	0.002	0.002
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0058	0.0257	0.0442
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0038	0.0119	0.0463
Brugia malayi	G protein-coupled receptor	0.0022	0.0001	0.0001
Brugia malayi	AKH receptor	0.0022	0.0001	0.0001
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0038	0.0119	1
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0031	0.0065	0.0209
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0038	0.0119	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0257	0.0257
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0031	0.0065	0.0295
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.1423	1	1
Schistosoma mansoni	ATPase	0.0038	0.0119	0.0547
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0058	0.0257	0.1185
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0072	0.0359	0.1584
Brugia malayi	neuropeptide F receptor	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0072	0.0359	0.1658
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0058	0.0257	0.1185
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0038	0.0119	0.0463
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0001	0.0001
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0058	0.0257	0.0442
Brugia malayi	larval opioid receptor	0.0022	0.0001	0.0001
Toxoplasma gondii	mono- or diacylglycerol acyltransferase	0.0072	0.0359	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0058	0.0257	0.0442
Schistosoma mansoni	ATPase	0.0038	0.0119	0.0547
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0072	0.0359	0.1658
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0038	0.0119	0.0463
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0031	0.0065	0.0295
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0038	0.0119	0.0204
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0001	0.0001
Brugia malayi	Serotonin receptor	0.0473	0.3221	0.3221
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.0001	0.0001
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0026	0.0032	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0001	0.0001
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0031	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0058	0.0257	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0038	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0038	0.0119	0.0463
Onchocerca volvulus		0.0058	0.0257	0.1185
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0058	0.0257	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0031	0.0065	0.0209
Brugia malayi	GnHR receptor homolog	0.0022	0.0001	0.0001
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0325	0.2162	0.2162
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0072	0.0359	0.1584
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus multilocularis	nervana 2	0.0058	0.0257	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Toxoplasma gondii	P-type ATPase4, putative	0.0038	0.0119	0.0463
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0038	0.0119	0.0119
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0031	0.0065	0.0209
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0058	0.0257	0.1185
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0038	0.0119	0.0463
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Brugia malayi	E1-E2 ATPase family protein	0.0024	0.002	0.002
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0038	0.0119	0.0463
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0038	0.0119	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Leishmania major	calcium motive p-type ATPase, putative	0.0031	0.0065	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Echinococcus granulosus	nervana 2	0.0058	0.0257	0.0442
Brugia malayi	putative neuropeptide receptor	0.0022	0.0001	0.0001
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0001	0.0001
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0031	0.0065	0.0295
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0058	0.0257	0.0442
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0325	0.2162	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Leishmania major	hypothetical protein, unknown function,protein, unknown function	0.0072	0.0359	0.1584
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.0001	0.0001
Brugia malayi	Dopamine receptor	0.0022	0.0001	0.0001
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0001	0.0001
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0031	0.0065	0.011
Leishmania major	calcium-translocating P-type ATPase	0.0038	0.0119	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0119	0.0119
Brugia malayi	RE15519p	0.0022	0.0001	0.0001
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0038	0.0119	0.2672
Brugia malayi	diacylglycerol acyltransferase family protein	0.0325	0.2162	0.2162
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0038	0.0119	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0038	0.0119	0.0204
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0001	0.0001
Onchocerca volvulus		0.0038	0.0119	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0031	0.0065	0.011
Echinococcus granulosus	nervana 2	0.0058	0.0257	0.0442
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0026	0.0032	0.5
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0038	0.0119	1
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0325	0.2162	1
Brugia malayi	Na,K-ATPase alpha subunit	0.0038	0.0119	0.0119
Leishmania major	diacylglycerol acyltransferase, putative	0.0072	0.0359	0.1584
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0038	0.0119	0.0463
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0038	0.0119	0.0463
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Brugia malayi	Membrane calcium atpase protein 3	0.0031	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0001	0.0001
Echinococcus multilocularis	calcium transporting atpase	0.0031	0.0065	0.011
Schistosoma mansoni	transmemberane protein	0.0058	0.0257	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0031	0.0065	0.011
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0072	0.0359	0.1584
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0038	0.0119	0.0463
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0001	0.0001
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0038	0.0119	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0001	0.0001
Echinococcus multilocularis	nervana 2	0.0058	0.0257	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0031	0.0065	0.0295
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0031	0.0065	0.0209
Brugia malayi	hypothetical protein	0.0022	0.0001	0.0001
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0325	0.2162	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0001	0.0001
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0031	0.0065	0.011
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0026	0.0032	0.0032
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0325	0.2162	1
Brugia malayi	Serotonin receptor	0.0022	0.0001	0.0001
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0001	0.0001
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0058	0.0257	0.1185
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0038	0.0119	0.0204
Brugia malayi	sulfakinin receptor protein	0.0022	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0119	0.0119
Leishmania major	calcium-transporting ATPase, putative	0.0031	0.0065	0.0209

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.9 uM	Cytotoxicity against human Molt4 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 1.9 uM	Cytotoxicity against human Molt4 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 3.6 uM	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 3.6 uM	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 6.6 uM	Cytotoxicity against human K562 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 6.6 uM	Cytotoxicity against human K562 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 13.3 uM	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 13.3 uM	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 15.9 uM	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	ChEMBL.	16777409
IC50 (functional)	= 15.9 uM	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	ChEMBL.	16777409
MIC90 (functional)	= 1.8 ug ml-1	Antitubercular activity against Mycobacterium tuberculosis H37Rv isolate ITR after 7 days by luminescence spectrometry	ChEMBL.	22691154
MIC90 (functional)	= 1.8 ug ml-1	Antitubercular activity against Mycobacterium tuberculosis H37Rv incubated for 10 days in anaerobic condition followed by 48 hrs incubation in aerobic condition by LORA assay	ChEMBL.	22691154
MIC90 (functional)	= 2.5 ug ml-1	Antitubercular activity against Mycobacterium tuberculosis H37Rv isolate SRI after 5 days by resazurin-based microplate assay	ChEMBL.	22691154

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	16777409

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL214298

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 367892