TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.223 | Formula: C19H13BrN2O2
H donors: 1 H acceptors: 3 LogP: 4.52 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1c(Br)n(c(c1c1ccc(cc1)c1ccccc1)C(=O)O)C
InChi: 1S/C19H13BrN2O2/c1-22-17(19(23)24)16(15(11-21)18(22)20)14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-10H,1H3,(H,23,24)
InChiKey: GBUJJYBSRJRTJJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, ionotropic, AMPA 4	Starlite/ChEMBL	References
Homo sapiens	glutamate receptor, ionotropic, AMPA 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 2 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 1 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA 2	883 aa	810 aa	34.0 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	glutamate receptor, ionotropic, AMPA 4	902 aa	818 aa	33.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0109	0.0322	0.4722
Entamoeba histolytica	heat shock protein 90, putative	0.0163	0.0681	1
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.013	0.0461	0.0461
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0109	0.0322	0.0978
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Trichomonas vaginalis	heat shock protein, putative	0.0163	0.0681	1
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Trypanosoma brucei	Heat shock protein 83, putative	0.0163	0.0681	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.1564	1	1
Echinococcus granulosus	endoplasmin	0.013	0.0461	0.0461
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0068	0.0052	0.0691
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Loa Loa (eye worm)	phosphatidylinositol 3	0.0109	0.0322	0.4722
Echinococcus multilocularis	heat shock protein	0.0163	0.0681	0.0681
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Toxoplasma gondii	Hsp90 domain-containing protein	0.0067	0.0041	0.0527
Trypanosoma brucei	heat shock protein 90, putative	0.0163	0.0681	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trypanosoma cruzi	heat shock protein 85, putative	0.013	0.0461	0.1408
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0061	0.0006	0.0084
Loa Loa (eye worm)	glutamate receptor 1	0.0163	0.0679	0.9961
Trichomonas vaginalis	heat shock protein, putative	0.013	0.0461	0.6731
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.0076	0.0076
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Echinococcus multilocularis	glutamate receptor 2	0.0174	0.0755	0.0755
Trypanosoma cruzi	heat shock protein 85, putative	0.0163	0.0681	0.2092
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0109	0.0322	0.0841
Schistosoma mansoni	heat shock protein	0.0163	0.0681	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Loa Loa (eye worm)	endoplasmin	0.0163	0.0681	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.013	0.0461	0.5
Echinococcus granulosus	serine protein kinase ATM	0.0061	0.0006	0.0006
Trypanosoma brucei	heat shock protein 90, putative	0.0163	0.0681	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0109	0.0322	0.0322
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0124	0.0425	0.0425
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0109	0.0322	0.4677
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0061	0.0006	0.0006
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0061	0.0006	0.0084
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.013	0.0461	0.5
Echinococcus granulosus	heat shock protein 90	0.0163	0.0681	0.0681
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0109	0.0322	0.4677
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.0076	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trypanosoma cruzi	Heat shock protein 83, putative	0.0163	0.0681	0.2092
Echinococcus granulosus	glutamate receptor 4	0.0102	0.0276	0.0276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Loa Loa (eye worm)	phosphatidylinositol 3	0.0109	0.0322	0.4722
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Toxoplasma gondii	heat shock protein 75, putative	0.0067	0.0041	0.0527
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0109	0.0322	0.0322
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0109	0.0322	0.0841
Trypanosoma brucei	heat shock protein 84, putative	0.0067	0.0041	0.0527
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0109	0.0322	0.0841
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.0076	0.0076
Schistosoma mansoni	endoplasmin	0.0163	0.0681	1
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trypanosoma cruzi	heat shock protein 90, putative	0.0096	0.0237	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0276	0.4047
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0163	0.0681	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0109	0.0322	0.0978
Loa Loa (eye worm)	heat shock protein 90	0.0163	0.0681	1
Echinococcus granulosus	glutamate receptor 2	0.0174	0.0755	0.0755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0109	0.0322	0.4677
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0109	0.0322	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0276	0.4047
Toxoplasma gondii	heat shock protein HSP90	0.0163	0.0681	1
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.013	0.0461	0.1258
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0174	0.0755	0.0755
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0109	0.0322	0.4677
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0068	0.0052	0.0691
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Echinococcus multilocularis	glutamate receptor 2	0.0163	0.0679	0.0679
Echinococcus granulosus	heat shock protein 90	0.013	0.0461	0.0461
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.0076	0.0076
Giardia lamblia	Grp94/Hsp90	0.013	0.0461	0.386
Loa Loa (eye worm)	heat shock protein 75	0.0067	0.0041	0.0606
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0109	0.0322	0.4677
Trypanosoma cruzi	heat shock protein 90, putative	0.0163	0.0681	0.2092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Echinococcus multilocularis	heat shock protein 90	0.013	0.0461	0.0461
Trypanosoma cruzi	target of rapamycin kinase 3	0.0109	0.0322	0.0978
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Plasmodium falciparum	endoplasmin, putative	0.01	0.0262	0.345
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0067	0.0041	0.5
Plasmodium falciparum	heat shock protein 90	0.0163	0.0681	1
Echinococcus granulosus	glutamate receptor 1	0.0102	0.0276	0.0276
Echinococcus multilocularis	glutamate receptor 2	0.0152	0.0606	0.0606
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0109	0.0322	0.4677
Trypanosoma cruzi	hypothetical protein, conserved	0.0547	0.3235	1
Mycobacterium ulcerans	heat shock protein 90	0.013	0.0461	0.5
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0174	0.0755	0.0755
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	endoplasmin, putative	0.01	0.0262	0.3795
Leishmania major	hypothetical protein, conserved	0.0568	0.3375	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0109	0.0322	0.4722
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0072	0.0076	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0276	0.4047
Trichomonas vaginalis	heat shock protein, putative	0.013	0.0461	0.6731
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0109	0.0322	0.0841
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0067	0.0041	0.0041
Schistosoma mansoni	heat shock protein	0.0067	0.0041	0.0606
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0068	0.0052	0.0691
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Schistosoma mansoni	heat shock protein	0.0163	0.0681	1
Echinococcus multilocularis	glutamate receptor 4	0.0102	0.0276	0.0276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Treponema pallidum	heat shock protein 90	0.013	0.0461	0.5
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0052	0.0691
Trypanosoma cruzi	heat shock protein, putative	0.0067	0.0041	0.011
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Brugia malayi	Endoplasmin precursor	0.0163	0.0681	1
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.013	0.0461	0.5
Trypanosoma cruzi	heat shock protein 90, putative	0.013	0.0461	0.1408
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0061	0.0006	0.0006
Echinococcus granulosus	heat shock protein	0.0163	0.0681	0.0681
Brugia malayi	Glutamate receptor 1 precursor	0.0163	0.0679	0.9961
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0072	0.0076	0.0076
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0109	0.0322	0.0322
Trichomonas vaginalis	heat shock protein, putative	0.0067	0.0041	0.0527
Echinococcus multilocularis	endoplasmin	0.013	0.0461	0.0461
Echinococcus multilocularis	serine protein kinase ATM	0.0061	0.0006	0.0006
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0109	0.0322	0.4677
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0067	0.0041	0.0041
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0109	0.0322	0.0978
Brugia malayi	heat shock protein 90	0.0163	0.0681	1
Trichomonas vaginalis	heat shock protein, putative	0.013	0.0461	0.6731
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0124	0.0425	0.0425
Plasmodium vivax	endoplasmin, putative	0.0163	0.0681	1
Plasmodium vivax	heat shock protein 86, putative	0.0163	0.0681	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0163	0.0681	0.2092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Schistosoma mansoni	endoplasmin	0.0163	0.0681	1
Echinococcus multilocularis	heat shock protein 90	0.0163	0.0681	0.0681
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0109	0.0322	0.0322
Schistosoma mansoni	glutamate receptor NMDA	0.0072	0.0076	0.1122
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Entamoeba histolytica	heat shock protein 90, putative	0.0163	0.0681	1
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0067	0.0041	0.0527
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0109	0.0322	0.0978
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Trichomonas vaginalis	heat shock protein, putative	0.01	0.0262	0.3795
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0006	0.0084
Leishmania major	heat shock protein 83-1	0.0163	0.0681	0.192
Toxoplasma gondii	heat shock protein 90, putative	0.0163	0.0681	1
Trypanosoma brucei	heat shock protein, putative	0.0163	0.0681	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0052	0.0769
Echinococcus granulosus	glutamate receptor 2	0.0152	0.0606	0.0606
Trypanosoma cruzi	heat shock protein 85, putative	0.0163	0.0681	0.2092
Brugia malayi	Glutamate receptor 2 precursor	0.0163	0.0679	0.9961
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0109	0.0322	0.4677
Giardia lamblia	Heat shock protein HSP 90-alpha	0.013	0.0461	0.386
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0109	0.0322	0.4677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0109	0.0322	0.4677
Brugia malayi	Hsp90 protein	0.0067	0.0041	0.0527

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 679 nM	Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827
EC50 (functional)	= 679 nM	Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827
EC50 (functional)	= 1689 nM	Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827
EC50 (functional)	= 1689 nM	Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827
EC50 (functional)	> 3 uM	Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827
EC50 (functional)	> 3 uM	Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827
EC50 (functional)	> 3 uM	Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827
EC50 (functional)	> 3 uM	Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glutamate by FLIPR assay	ChEMBL.	16872827

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL385704

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 372236