TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 436.272 | Formula: C20H19BrFNO4
H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@H]1OC(=C2C1=NC1=C([C@H]2c2ccc(c(c2)Br)F)C(=O)COC1(C)C)O
InChi: 1S/C20H19BrFNO4/c1-4-13-17-16(19(25)27-13)14(9-5-6-11(22)10(21)7-9)15-12(24)8-26-20(2,3)18(15)23-17/h5-7,13-14,25H,4,8H2,1-3H3/t13-,14-/m1/s1
InChiKey: WLRALWDNXQLRMA-ZIAGYGMSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium inwardly-rectifying channel, subfamily J, member 11	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cyclin A3 4	0.0007	0.0001	0.0003
Echinococcus granulosus	cyclin k	0.0007	0.0001	0.0003
Entamoeba histolytica	hypothetical protein	0.0007	0.0001	0.0009
Brugia malayi	cyclin fold protein 1 variant b	0.0007	0.0001	0.0003
Schistosoma mansoni	hypothetical protein	0.0007	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Loa Loa (eye worm)	cyclin domain-containing protein	0.0007	0.0001	0.0003
Schistosoma mansoni	unc-13 (munc13)	0.0007	0.0001	0.0006
Echinococcus multilocularis	cyclins	0.003	0.0292	0.1118
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0292	0.3516
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0008	0.0007	0.0029
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0007	0.0001	0.0003
Loa Loa (eye worm)	cyclin domain-containing protein	0.0007	0.0001	0.0003
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0039	0.015
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0399	0.153
Echinococcus granulosus	myotubularin protein 13	0.0007	0.0001	0.0006
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0039	0.0399	0.153
Loa Loa (eye worm)	cyclin domain-containing protein	0.0007	0.0001	0.0003
Onchocerca volvulus		0.0072	0.0828	1
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0008	0.0007	0.0028
Schistosoma mansoni	rac gtpase activating protein	0.0007	0.0001	0.0006
Leishmania major	cyclin	0.0072	0.0828	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0042	0.0441	0.532
Loa Loa (eye worm)	raf kinase	0.0209	0.2569	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0039	0.0399	0.153
Echinococcus granulosus	G1:S specific cyclin D1	0.0007	0.0001	0.0003
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0039	0.015
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0072	0.0828	1
Trichomonas vaginalis	cyclin A, putative	0.0072	0.0828	1
Echinococcus multilocularis	cyclin B	0.0072	0.0828	0.3174
Echinococcus granulosus	raf serine:threonine protein kinase	0.0212	0.2608	1
Trypanosoma brucei	cdc2-related kinase 3	0.0042	0.0441	0.532
Schistosoma mansoni	serine/threonine protein kinase	0.0212	0.2608	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1205	0.4691
Echinococcus granulosus	unc 13 munc13	0.0007	0.0001	0.0006
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0212	0.2608	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0042	0.0441	0.169
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0007	0.0001	0.0003
Schistosoma mansoni	Cyclin fold protein	0.0007	0.0001	0.0003
Entamoeba histolytica	cyclin, putative	0.003	0.0292	0.3516
Schistosoma mansoni	g1/s-specific cyclin C	0.0007	0.0001	0.0003
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0102	0.1205	0.4691
Echinococcus granulosus	protein kinase c eta type	0.0007	0.0001	0.0006
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0035	0.0354	0.1356
Echinococcus granulosus	cyclin y	0.0007	0.0001	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0007	0.0028
Trichomonas vaginalis	cyclin B, putative	0.0072	0.0828	1
Brugia malayi	hypothetical protein	0.0007	0.0001	0.0003
Echinococcus granulosus	Diacylglycerol kinase theta	0.0007	0.0001	0.0006
Loa Loa (eye worm)	TK protein kinase	0.0035	0.0354	0.1377
Schistosoma mansoni	unc-13 (munc13)	0.0007	0.0001	0.0006
Echinococcus granulosus	cyclin B	0.0072	0.0828	0.3174
Entamoeba histolytica	diacylglycerol kinase, putative	0.0007	0.0001	0.0009
Brugia malayi	Ras association domain family 1 isoform A	0.0007	0.0001	0.0006
Trypanosoma cruzi	cyclin 6, putative	0.0072	0.0828	1
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0008	0.0007	0.0028
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0035	0.0354	0.1356
Echinococcus granulosus	Protein kinase C brain isozyme	0.0008	0.0007	0.0028
Echinococcus multilocularis	cyclin dependent kinase 1	0.0042	0.0441	0.169
Trichomonas vaginalis	cyclins, putative	0.0072	0.0828	1
Brugia malayi	RhoGAP domain containing protein	0.0011	0.0048	0.0191
Brugia malayi	Cyclin C	0.0007	0.0001	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0007	0.0028
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0042	0.0441	0.1716
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Loa Loa (eye worm)	cyclin domain-containing protein	0.0007	0.0001	0.0003
Plasmodium falciparum	protein kinase 5	0.0042	0.0441	1
Trichomonas vaginalis	CMGC family protein kinase	0.0042	0.0441	0.532
Trichomonas vaginalis	cyclins, putative	0.0049	0.0537	0.6484
Plasmodium vivax	protein kinase Crk2	0.0042	0.0441	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0828	0.3222
Echinococcus multilocularis	G1:S specific cyclin D1	0.0007	0.0001	0.0003
Echinococcus granulosus	cyclins	0.003	0.0292	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Brugia malayi	Raf kinase	0.0205	0.2515	1
Echinococcus granulosus	cyclin G2	0.0007	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0003
Brugia malayi	Cyclin, N-terminal domain containing protein	0.003	0.0292	0.1159
Echinococcus multilocularis	cyclin B3 1	0.003	0.0292	0.1118
Brugia malayi	cell division control protein 2 homolog	0.0042	0.0441	0.1753
Echinococcus granulosus	cyclin dependent kinase 5	0.0042	0.0441	0.169
Entamoeba histolytica	cell division protein kinase 2, putative	0.0042	0.0441	0.532
Echinococcus multilocularis	Cyclin L1	0.0007	0.0001	0.0003
Trichomonas vaginalis	cyclins, putative	0.0072	0.0828	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0121	0.145	0.5645
Echinococcus multilocularis	cyclin G2	0.0007	0.0001	0.0003
Echinococcus multilocularis	cyclin y	0.0007	0.0001	0.0003
Brugia malayi	diacylglycerol kinase	0.0007	0.0001	0.0006
Brugia malayi	Protein kinase c protein 2	0.0008	0.0007	0.0029
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0042	0.0441	0.1716
Trypanosoma cruzi	cyclin, putative	0.0072	0.0828	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0307	0.1196
Schistosoma mansoni	cyclins	0.003	0.0292	0.1118
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0007	0.0001	0.0006
Giardia lamblia	Kinase, CMGC CDK	0.0042	0.0441	0.532
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0042	0.0441	0.3653
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0007	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0441	0.169
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0032	0.0315	0.1206
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0039	0.0405	0.1552
Schistosoma mansoni	vav2	0.0011	0.0048	0.0184
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0039	0.0399	0.153
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0039	0.0399	0.153
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0072	0.0828	1
Echinococcus granulosus	cyclin dependent kinase 1	0.0042	0.0441	0.169
Echinococcus multilocularis	cyclins	0.003	0.0292	0.1118
Echinococcus granulosus	cyclin G2	0.0007	0.0001	0.0003
Echinococcus granulosus	cyclins	0.003	0.0292	0.1118
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0007	0.0028
Echinococcus granulosus	N chimaerin	0.0011	0.0048	0.0184
Loa Loa (eye worm)	CYL-1 protein	0.0007	0.0001	0.0003
Entamoeba histolytica	cyclin, putative	0.0072	0.0828	1
Echinococcus granulosus	cyclin B3 1	0.003	0.0292	0.1118
Brugia malayi	diacylglycerol kinase	0.0007	0.0001	0.0006
Echinococcus multilocularis	cyclin k	0.0007	0.0001	0.0003
Trichomonas vaginalis	cyclin B3, putative	0.003	0.0292	0.3516
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0039	0.0399	0.153
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0039	0.0399	0.153
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0007	0.0001	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0399	0.153
Toxoplasma gondii	hypothetical protein	0.0023	0.0199	0.1647
Brugia malayi	hypothetical protein	0.0007	0.0001	0.0003
Echinococcus multilocularis	protein kinase c iota type	0.0008	0.0007	0.0028
Schistosoma mansoni	diacylglycerol kinase theta	0.0007	0.0001	0.0006
Schistosoma mansoni	protein kinase C	0.0007	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0435	0.1693
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0011	0.0048	0.0184
Schistosoma mansoni	cyclin G2	0.0007	0.0001	0.0003
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0032	0.0315	0.1206
Echinococcus multilocularis	cyclins	0.003	0.0292	0.1118
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0011	0.0048	0.0184
Echinococcus granulosus	cyclin b3	0.003	0.0292	0.1118
Brugia malayi	SRC-1	0.0039	0.0399	0.1586
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0007	0.0001	0.0006
Trypanosoma cruzi	cdc2-related kinase 1	0.0042	0.0441	0.532
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0072	0.0828	0.3292
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0039	0.0399	0.153
Schistosoma mansoni	tyrosine kinase	0.0039	0.0399	0.153
Echinococcus granulosus	cyclin t1	0.0007	0.0001	0.0003
Loa Loa (eye worm)	SRC-1	0.0039	0.0399	0.1553
Schistosoma mansoni	tyrosine kinase	0.001	0.0039	0.015
Schistosoma mansoni	tyrosine kinase	0.001	0.0039	0.015
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0007	0.0001	0.0003
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0042	0.0441	0.532
Trichomonas vaginalis	cyclins, putative	0.0072	0.0828	1
Onchocerca volvulus		0.0007	0.0001	0.0009
Schistosoma mansoni	hypothetical protein	0.0007	0.0001	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0399	0.153
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0007	0.0001	0.0003
Onchocerca volvulus		0.0007	0.0001	0.0009
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0008	0.0007	0.0028
Trichomonas vaginalis	cyclins, putative	0.0072	0.0828	1
Schistosoma mansoni	hypothetical protein	0.0007	0.0001	0.0003
Trichomonas vaginalis	cyclin B, putative	0.003	0.0292	0.3516
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0445	0.173
Echinococcus multilocularis	myotubularin protein 13	0.0007	0.0001	0.0006
Echinococcus granulosus	cyclins	0.003	0.0292	0.1118
Toxoplasma gondii	hypothetical protein	0.0102	0.1205	1
Schistosoma mansoni	cyclin k	0.0007	0.0001	0.0003
Trichomonas vaginalis	cyclin B, putative	0.0072	0.0828	1
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0007	0.0028
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0042	0.0441	0.169
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0035	0.0354	0.1356
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0042	0.0441	0.532
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0039	0.0399	0.153
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0008	0.0007	0.0028
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0039	0.0399	0.153
Echinococcus granulosus	cyclin y	0.0007	0.0001	0.0003
Echinococcus multilocularis	protein kinase c epsilon type	0.0008	0.0007	0.0028
Echinococcus multilocularis	cyclin	0.0007	0.0001	0.0003
Loa Loa (eye worm)	cyclin domain-containing protein	0.0007	0.0001	0.0003
Echinococcus multilocularis	cyclins	0.003	0.0292	0.1118
Brugia malayi	Variant SH3 domain containing protein	0.0011	0.0048	0.0191
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.003	0.0292	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Echinococcus multilocularis	protein kinase c eta type	0.0007	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Schistosoma mansoni	cyclin l	0.0007	0.0001	0.0003
Echinococcus granulosus	cyclins	0.0007	0.0001	0.0003
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0039	0.0399	0.153
Trichomonas vaginalis	CMGC family protein kinase	0.0042	0.0441	0.532
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0039	0.015
Echinococcus multilocularis	cyclin b3	0.003	0.0292	0.1118
Entamoeba histolytica	cyclin family protein	0.003	0.0292	0.3516
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Schistosoma mansoni	diacylglycerol kinase theta	0.0007	0.0001	0.0006
Brugia malayi	RhoGAP domain containing protein	0.0007	0.0001	0.0006
Giardia lamblia	Cyclin A	0.003	0.0292	0.3516
Trichomonas vaginalis	cyclin D, putative	0.003	0.0292	0.3516
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0007	0.0001	0.0003
Echinococcus granulosus	cyclins	0.003	0.0292	0.1118
Schistosoma mansoni	tyrosine kinase	0.0039	0.0399	0.153
Trypanosoma cruzi	cdc2-related kinase 1	0.0042	0.0441	0.532
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0007	0.0001	0.0003
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0039	0.0399	0.153
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0007	0.0001	0.0006
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0007	0.0001	0.0006
Trypanosoma cruzi	cdc2-related kinase 3	0.0042	0.0441	0.532
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0042	0.0441	0.1716
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0828	0.3222
Entamoeba histolytica	diacylglycerol kinase, putative	0.0007	0.0001	0.0009
Mycobacterium ulcerans	haloalkane dehalogenase	0.0794	1	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0039	0.0156
Schistosoma mansoni	cyclin G	0.0007	0.0001	0.0003
Brugia malayi	RhoGEF domain containing protein	0.0007	0.0001	0.0006
Trichomonas vaginalis	cyclin B, putative	0.0072	0.0828	1
Echinococcus multilocularis	cyclins	0.003	0.0292	0.1118
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.003	0.0292	0.1118
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0039	0.015
Loa Loa (eye worm)	cyclin domain-containing protein	0.0007	0.0001	0.0003
Schistosoma mansoni	protein kinase C mu	0.0008	0.0007	0.0028
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0007	0.0001	0.0003
Echinococcus multilocularis	cyclin dependent kinase 5	0.0042	0.0441	0.169
Echinococcus multilocularis	cyclin y	0.0007	0.0001	0.0003
Echinococcus granulosus	Rac GTPase activating protein 1	0.0007	0.0001	0.0006
Echinococcus granulosus	tyrosine protein kinase Blk	0.0035	0.0354	0.1356
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0006
Brugia malayi	protein-tyrosine kinase	0.0035	0.0354	0.1406
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0011	0.0048	0.0184
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0039	0.0399	0.153
Echinococcus multilocularis	unc 13 (munc13)	0.0007	0.0001	0.0006
Echinococcus multilocularis	cyclin A3 4	0.0007	0.0001	0.0003
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0011	0.0048	0.0184
Echinococcus multilocularis	cyclin t1	0.0007	0.0001	0.0003
Trypanosoma brucei	cdc2-related kinase 1	0.0042	0.0441	0.532
Onchocerca volvulus		0.0007	0.0001	0.0009
Brugia malayi	Pleckstrin Homology Domain	0.0007	0.0001	0.0006
Echinococcus granulosus	cyclin dependent kinase	0.0042	0.0441	0.169
Plasmodium falciparum	cyclin	0.003	0.0292	0.6609
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0039	0.015
Schistosoma mansoni	cyclin d	0.0007	0.0001	0.0003
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0039	0.015
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0008	0.0007	0.0028
Schistosoma mansoni	cyclin B3	0.003	0.0292	0.1118
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0007	0.0001	0.0003
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0031	0.0307	0.1178
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0007	0.0001	0.0003
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0039	0.0399	0.153
Echinococcus multilocularis	cyclin dependent kinase	0.0042	0.0441	0.169
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0007	0.0001	0.0006
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0008	0.0007	0.0028
Giardia lamblia	Kinase, CMGC CDK	0.0042	0.0441	0.532
Trichomonas vaginalis	CMGC family protein kinase	0.0042	0.0441	0.532
Giardia lamblia	Hypothetical protein	0.003	0.0292	0.3516
Echinococcus granulosus	tyrosine protein kinase HCK	0.0031	0.0307	0.1178
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0072	0.0828	0.3292
Brugia malayi	C1-like domain containing protein	0.0008	0.0007	0.0029
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0007	0.0001	0.0003
Echinococcus granulosus	cyclins	0.003	0.0292	0.1118
Trypanosoma cruzi	cyclin, putative	0.0072	0.0828	1
Schistosoma mansoni	cyclin B	0.0072	0.0828	0.3174
Trichomonas vaginalis	cyclin B, putative	0.0072	0.0828	1
Echinococcus granulosus	tyrosine kinase	0.0035	0.0354	0.1356
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0035	0.0354	0.1356
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0007	0.0001	0.0003
Brugia malayi	protein kinase C3,putative	0.0008	0.0007	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1205	0.4691
Entamoeba histolytica	cell division protein kinase 2, putative	0.0042	0.0441	0.532
Echinococcus granulosus	Cyclin L1	0.0007	0.0001	0.0003
Echinococcus multilocularis	cyclins	0.003	0.0292	0.1118
Echinococcus multilocularis	cyclin G2	0.0007	0.0001	0.0003
Echinococcus granulosus	cyclin	0.0007	0.0001	0.0003
Schistosoma mansoni	serine/threonine protein kinase	0.0008	0.0007	0.0028
Echinococcus granulosus	protein kinase c iota type	0.0008	0.0007	0.0028
Toxoplasma gondii	diacylglycerol kinase, putative	0.0007	0.0001	0.0006
Loa Loa (eye worm)	cyclin C	0.0007	0.0001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0441	0.1753
Loa Loa (eye worm)	cyclin domain-containing protein	0.003	0.0292	0.1135
Echinococcus granulosus	protein kinase c epsilon type	0.0008	0.0007	0.0028
Schistosoma mansoni	protein kinase C mu	0.0007	0.0001	0.0006
Trichomonas vaginalis	cyclins, putative	0.003	0.0292	0.3516
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1205	0.4691
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0011	0.0048	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0003
Trypanosoma brucei	mitotic cyclin 6	0.0072	0.0828	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0307	0.3706
Entamoeba histolytica	cyclin family protein	0.003	0.0292	0.3516
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0007	0.0029
Echinococcus multilocularis	N chimaerin	0.0011	0.0048	0.0184
Trichomonas vaginalis	cyclin D, putative	0.003	0.0292	0.3516
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0007	0.0001	0.0006
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0007	0.0001	0.0006
Brugia malayi	protein kinase C II.	0.0008	0.0007	0.0029
Giardia lamblia	G2/mitotic-specific cyclin B	0.0072	0.0828	1
Echinococcus multilocularis	cyclins	0.003	0.0292	0.1118
Schistosoma mansoni	atypical protein kinase C	0.0008	0.0007	0.0028
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0441	0.169

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= -5.8	Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay	ChEMBL.	17154517
EC50 (functional)	= -5.46	Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay	ChEMBL.	17154517
EC50 (functional)	< -5	Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay	ChEMBL.	17154517
Efficacy (functional)	= 48 %	Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075	ChEMBL.	17154517
Efficacy (functional)	= 48 %	Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075	ChEMBL.	17154517
Efficacy (functional)	= 77 %	Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075	ChEMBL.	17154517
Efficacy (functional)	= 77 %	Ability to open human urinary bladder Kir6.2 containing SUR2B in Ltk cells by FLIPR assay relative to P1075	ChEMBL.	17154517
Log EC50 (functional)	< 5	Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay	ChEMBL.	17154517
Log EC50 (functional)	= 5.46	Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay	ChEMBL.	17154517
Log EC50 (functional)	= 5.8	Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assay	ChEMBL.	17154517

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 373937