Detailed information for compound 374645

Basic information

Technical information
  • TDR Targets ID: 374645
  • Name: (2-ethylphenyl)methanol
  • MW: 136.191 | Formula: C9H12O
  • H donors: 1 H acceptors: 1 LogP: 1.83 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1ccccc1CC
  • InChi: 1S/C9H12O/c1-2-8-5-3-4-6-9(8)7-10/h3-6,10H,2,7H2,1H3
  • InChiKey: SBUIQTMDIOLKAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 12M
  • 2-Ethylbenzyl alcohol
  • 525030_ALDRICH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0053 0.0002 0.0002
Giardia lamblia Heat shock protein HSP 90-alpha 0.0066 0.01 0.01
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0053 0.0002 0.0002
Echinococcus granulosus Cyclin L1 0.0053 0.0002 0.0002
Trypanosoma brucei Heat shock protein 83, putative 0.0066 0.01 0.0098
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0097 0.0324 0.0323
Echinococcus granulosus heat shock protein 90 0.0066 0.01 0.01
Trypanosoma cruzi Heat shock protein 83, putative 0.0066 0.01 0.01
Trypanosoma cruzi cdc2-related kinase 1 0.0464 0.3035 0.3035
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0105 0.0389 0.0388
Echinococcus granulosus cyclin dependent kinase 1 0.0464 0.3035 0.3035
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.01 0.01
Schistosoma mansoni serine/threonine protein kinase 0.0464 0.3035 0.3034
Echinococcus multilocularis dual specificity 0.011 0.042 0.042
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.011 0.042 0.042
Echinococcus granulosus cyclin y 0.0053 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus granulosus cyclins 0.0053 0.0002 0.0002
Echinococcus multilocularis cyclins 0.022 0.1233 0.1233
Loa Loa (eye worm) cyclin domain-containing protein 0.0908 0.6318 0.6318
Echinococcus granulosus defective proboscis extension response 0.0097 0.0324 0.0324
Trichomonas vaginalis heat shock protein, putative 0.0066 0.01 0.01
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.042 0.042
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.011 0.042 0.0419
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Trichomonas vaginalis CMGC family protein kinase 0.0464 0.3035 0.3035
Schistosoma mansoni vesicular amine transporter 0.0097 0.0324 0.0323
Echinococcus granulosus protein kinase shaggy 0.1407 1 1
Echinococcus granulosus cyclin G2 0.0053 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0548 0.3655 0.3655
Leishmania major mitotic cyclin, putative 0.0053 0.0002 0.0002
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0097 0.0324 0.0324
Giardia lamblia Kinase, CMGC GSK 0.1407 1 1
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0154 0.0745 0.0744
Leishmania major cyclin 9, putative 0.0053 0.0002 0.0002
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0053 0 0.5
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1407 1 1
Plasmodium falciparum heat shock protein 90 0.0066 0.01 0.0098
Trypanosoma cruzi cdc2-related kinase 1 0.0464 0.3035 0.3035
Toxoplasma gondii heat shock protein HSP90 0.0066 0.01 0.0098
Echinococcus multilocularis cyclin y 0.0053 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.011 0.042 0.0419
Trypanosoma brucei cdc2-related kinase 1 0.0464 0.3035 0.3034
Loa Loa (eye worm) endoplasmin 0.0066 0.01 0.0098
Echinococcus multilocularis cyclin dependent kinase 1 0.0464 0.3035 0.3035
Giardia lamblia Cyclin A 0.022 0.1233 0.1233
Brugia malayi Immunoglobulin I-set domain containing protein 0.0097 0.0324 0.0323
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Echinococcus multilocularis Immunoglobulin 0.0097 0.0324 0.0324
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1407 1 1
Entamoeba histolytica cyclin family protein 0.022 0.1233 0.1231
Plasmodium vivax protein kinase Crk2 0.0464 0.3035 0.3034
Schistosoma mansoni cyclins 0.022 0.1233 0.1231
Entamoeba histolytica cell division protein kinase 2, putative 0.0464 0.3035 0.3034
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Schistosoma mansoni cell adhesion molecule 0.0097 0.0324 0.0323
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1407 1 1
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0053 0 0.5
Echinococcus multilocularis cyclins 0.022 0.1233 0.1233
Brugia malayi cell division control protein 2 homolog 0.0464 0.3035 0.3034
Entamoeba histolytica protein kinase, putative 0.1407 1 1
Trichomonas vaginalis cyclin B, putative 0.0373 0.2368 0.2368
Trichomonas vaginalis cyclin D, putative 0.0053 0.0002 0.0002
Trichomonas vaginalis cyclins, putative 0.0053 0.0002 0.0002
Echinococcus multilocularis cyclin dependent kinase 5 0.0464 0.3035 0.3035
Trichomonas vaginalis cyclin B, putative 0.0373 0.2368 0.2368
Trichomonas vaginalis cyclins, putative 0.022 0.1233 0.1233
Schistosoma mansoni heat shock protein 0.0066 0.01 0.0098
Toxoplasma gondii hypothetical protein 0.0167 0.0841 0.084
Loa Loa (eye worm) hypothetical protein 0.0262 0.1547 0.1545
Echinococcus multilocularis Cyclin L1 0.0053 0.0002 0.0002
Echinococcus granulosus cyclins 0.022 0.1233 0.1233
Trypanosoma cruzi cyclin, putative 0.0373 0.2368 0.2368
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1407 1 1
Echinococcus granulosus cyclins 0.022 0.1233 0.1233
Echinococcus granulosus cyclins 0.022 0.1233 0.1233
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0464 0.3035 0.3035
Brugia malayi Fibronectin type III domain containing protein 0.0097 0.0324 0.0323
Trypanosoma brucei cdc2-related kinase 3 0.0464 0.3035 0.3034
Echinococcus multilocularis cyclin B3 1 0.022 0.1233 0.1233
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0464 0.3035 0.3035
Echinococcus multilocularis cyclin k 0.0053 0.0002 0.0002
Echinococcus granulosus cyclin t1 0.0053 0.0002 0.0002
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.011 0.042 0.0419
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Entamoeba histolytica protein kinase domain containing protein 0.011 0.042 0.0419
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0548 0.3655 0.3654
Plasmodium vivax heat shock protein 86, putative 0.0066 0.01 0.0098
Echinococcus granulosus cyclins 0.022 0.1233 0.1233
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1407 1 1
Brugia malayi heat shock protein 90 0.0066 0.01 0.0098
Trichomonas vaginalis cyclins, putative 0.0373 0.2368 0.2368
Echinococcus multilocularis cyclins 0.022 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Giardia lamblia Hypothetical protein 0.0053 0.0002 0.0002
Trichomonas vaginalis cyclin D, putative 0.022 0.1233 0.1233
Echinococcus multilocularis neuroglian 0.0097 0.0324 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0002 0.0002
Echinococcus granulosus cyclin B 0.0373 0.2368 0.2368
Leishmania major cyclin 0.0373 0.2368 0.2368
Loa Loa (eye worm) heat shock protein 90 0.0066 0.01 0.0098
Trypanosoma cruzi cdc2-related kinase 3 0.0464 0.3035 0.3035
Trichomonas vaginalis conserved hypothetical protein 0.022 0.1233 0.1233
Trypanosoma cruzi cdc2-related kinase 3 0.0464 0.3035 0.3035
Echinococcus multilocularis cyclins 0.022 0.1233 0.1233
Onchocerca volvulus 0.1407 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0464 0.3035 0.3035
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.01 0.0098
Trichomonas vaginalis cyclin B, putative 0.0373 0.2368 0.2368
Echinococcus multilocularis heat shock protein 0.0066 0.01 0.01
Entamoeba histolytica protein kinase, putative 0.011 0.042 0.0419
Plasmodium falciparum cyclin 0.022 0.1233 0.1231
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0908 0.6318 0.6318
Giardia lamblia Kinase, CMGC GSK 0.1407 1 1
Loa Loa (eye worm) hypothetical protein 0.0548 0.3655 0.3654
Trichomonas vaginalis cyclins, putative 0.0373 0.2368 0.2368
Trichomonas vaginalis cyclin B, putative 0.0053 0.0002 0.0002
Brugia malayi Cyclin, N-terminal domain containing protein 0.0908 0.6318 0.6318
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0097 0.0324 0.0324
Brugia malayi hypothetical protein 0.0262 0.1547 0.1545
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus granulosus heat shock protein 0.0066 0.01 0.01
Giardia lamblia Kinase, CMGC CDK 0.0464 0.3035 0.3035
Echinococcus granulosus cyclin A3 4 0.0053 0.0002 0.0002
Echinococcus granulosus cyclin b3 0.022 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0091 0.0279 0.0277
Trichomonas vaginalis cyclins, putative 0.0373 0.2368 0.2368
Echinococcus granulosus cyclin y 0.0053 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0262 0.1547 0.1545
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Entamoeba histolytica protein kinase domain containing protein 0.1407 1 1
Treponema pallidum heat shock protein 90 0.0053 0 0.5
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0548 0.3655 0.3655
Brugia malayi Cyclin, N-terminal domain containing protein 0.0373 0.2368 0.2366
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.01 0.0098
Echinococcus multilocularis cyclins 0.022 0.1233 0.1233
Echinococcus granulosus G1:S specific cyclin D1 0.0053 0.0002 0.0002
Brugia malayi Cyclin, N-terminal domain containing protein 0.0373 0.2368 0.2366
Trichomonas vaginalis CMGC family protein kinase 0.1407 1 1
Brugia malayi hypothetical protein 0.0097 0.0324 0.0323
Trypanosoma cruzi mitotic cyclin, putative 0.0053 0.0002 0.0002
Trichomonas vaginalis cyclin B, putative 0.0053 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0444 0.2894 0.2892
Giardia lamblia Cyclin fold protein 1, putative 0.0053 0.0002 0.0002
Entamoeba histolytica cell division protein kinase 2, putative 0.0464 0.3035 0.3034
Plasmodium vivax endoplasmin, putative 0.0066 0.01 0.0098
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus multilocularis roundabout 2 0.0097 0.0324 0.0324
Entamoeba histolytica cyclin, putative 0.0373 0.2368 0.2366
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Trypanosoma cruzi mitotic cyclin, putative 0.0053 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0091 0.0279 0.0277
Leishmania major mitotic cyclin, putative 0.0053 0.0002 0.0002
Plasmodium falciparum protein kinase 5 0.0464 0.3035 0.3034
Schistosoma mansoni heat shock protein 0.0066 0.01 0.0098
Entamoeba histolytica cyclin family protein 0.022 0.1233 0.1231
Toxoplasma gondii heat shock protein 90, putative 0.0066 0.01 0.0098
Giardia lamblia Cyclin B-like protein 0.0053 0.0002 0.0002
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1407 1 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0908 0.6318 0.6318
Echinococcus multilocularis cyclins 0.022 0.1233 0.1233
Echinococcus multilocularis heat shock protein 90 0.0066 0.01 0.01
Echinococcus multilocularis G1:S specific cyclin D1 0.0053 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.011 0.042 0.0419
Echinococcus granulosus twitchin 0.0116 0.0466 0.0466
Schistosoma mansoni nephrin 0.0097 0.0324 0.0323
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0464 0.3035 0.3034
Giardia lamblia Hypothetical protein 0.022 0.1233 0.1233
Entamoeba histolytica protein kinase domain containing protein 0.1407 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0464 0.3035 0.3035
Plasmodium vivax glycogen synthase kinase 3, putative 0.1407 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0066 0.01 0.01
Echinococcus granulosus cyclins 0.022 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0373 0.2368 0.2366
Echinococcus multilocularis cyclins 0.022 0.1233 0.1233
Trypanosoma cruzi cyclin, putative 0.0373 0.2368 0.2368
Echinococcus granulosus cyclin B3 1 0.022 0.1233 0.1233
Brugia malayi Protein kinase domain containing protein 0.0464 0.3035 0.3034
Trichomonas vaginalis cyclin B3, putative 0.022 0.1233 0.1233
Entamoeba histolytica cyclin, putative 0.022 0.1233 0.1231
Echinococcus multilocularis cyclin G2 0.0053 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0053 0.0002 0.0002
Schistosoma mansoni cyclin B 0.0373 0.2368 0.2366
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1407 1 1
Trichomonas vaginalis cyclin A, putative 0.0053 0.0002 0.0002
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0097 0.0324 0.0323
Onchocerca volvulus 0.0373 0.2368 0.2366
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1407 1 1
Echinococcus multilocularis cyclin y 0.0053 0.0002 0.0002
Trichomonas vaginalis cyclins, putative 0.0373 0.2368 0.2368
Trichomonas vaginalis cyclin B3, putative 0.0053 0.0002 0.0002
Trichomonas vaginalis cyclin A, putative 0.0373 0.2368 0.2368
Echinococcus granulosus cyclin G2 0.0053 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.01 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0464 0.3035 0.3034
Echinococcus granulosus cyclin dependent kinase 5 0.0464 0.3035 0.3035
Trichomonas vaginalis CMGC family protein kinase 0.1407 1 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.042 0.042
Trichomonas vaginalis cyclin B3, putative 0.0053 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Trypanosoma brucei mitotic cyclin 6 0.0373 0.2368 0.2366
Loa Loa (eye worm) hypothetical protein 0.0373 0.2368 0.2366
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Entamoeba histolytica hypothetical protein 0.011 0.042 0.0419
Trichomonas vaginalis CMGC family protein kinase 0.0464 0.3035 0.3035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0105 0.0389 0.0388
Echinococcus multilocularis cyclin 0.0053 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Trichomonas vaginalis cyclins, putative 0.0207 0.1137 0.1137
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0053 0 0.5
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Echinococcus granulosus Immunoglobulin 0.0097 0.0324 0.0324
Giardia lamblia Hypothetical protein 0.0053 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0002 0.0002
Schistosoma mansoni cyclin B3 0.0908 0.6318 0.6318
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0373 0.2368 0.2368
Echinococcus granulosus neuroglian 0.0097 0.0324 0.0324
Echinococcus multilocularis cyclin b3 0.022 0.1233 0.1233
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.01 0.01
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0464 0.3035 0.3034
Trypanosoma cruzi cyclin 6, putative 0.0373 0.2368 0.2368
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0002 0.0002
Echinococcus granulosus roundabout 2 0.0097 0.0324 0.0324
Echinococcus granulosus cyclin dependent kinase 0.0464 0.3035 0.3035
Echinococcus granulosus dual specificity 0.011 0.042 0.042
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Echinococcus multilocularis Immunoglobulin 0.0097 0.0324 0.0324
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0464 0.3035 0.3034
Trypanosoma cruzi cyclin 9, putative 0.0053 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Echinococcus multilocularis cyclin dependent kinase 0.0464 0.3035 0.3035
Echinococcus multilocularis cyclin t1 0.0053 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0097 0.0324 0.0323
Trichomonas vaginalis cyclin B, putative 0.022 0.1233 0.1233
Trypanosoma cruzi CYC2-like cyclin, putative 0.0373 0.2368 0.2368
Trichomonas vaginalis cyclins, putative 0.0053 0.0002 0.0002
Echinococcus multilocularis cyclin B 0.0373 0.2368 0.2368
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.01 0.01
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0464 0.3035 0.3034
Brugia malayi Endoplasmin precursor 0.0066 0.01 0.0098
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Echinococcus multilocularis protein kinase shaggy 0.1407 1 1
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.01 0.0098
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0053 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0066 0.01 0.01
Mycobacterium ulcerans heat shock protein 90 0.0053 0 0.5
Trypanosoma brucei heat shock protein, putative 0.0066 0.01 0.0098
Plasmodium falciparum glycogen synthase kinase 3 0.1407 1 1
Schistosoma mansoni endoplasmin 0.0066 0.01 0.0098
Entamoeba histolytica protein kinase, putative 0.011 0.042 0.0419
Echinococcus granulosus cyclin 0.0053 0.0002 0.0002
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0464 0.3035 0.3035
Trichomonas vaginalis cyclin B, putative 0.0373 0.2368 0.2368
Giardia lamblia G2/mitotic-specific cyclin B 0.0373 0.2368 0.2368
Trichomonas vaginalis cyclin D, putative 0.022 0.1233 0.1233
Echinococcus multilocularis cyclin G2 0.0053 0.0002 0.0002
Echinococcus multilocularis cyclin A3 4 0.0053 0.0002 0.0002
Schistosoma mansoni endoplasmin 0.0066 0.01 0.0098
Giardia lamblia Kinase, CMGC CDK 0.0464 0.3035 0.3035
Echinococcus granulosus cyclin k 0.0053 0.0002 0.0002
Trypanosoma brucei protein kinase, putative 0.1407 1 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1.34 mM Inhibition of Trypanosoma brucei brucei growth ChEMBL. 17004709

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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