TDR Targets

Basic information

Technical information

TDR Targets ID: 375601
Name: 6-(4-chlorophenyl)-3-[2-[(4-phenylpiperidin-1 -yl)methyl]quinolin-6-yl]thieno[3,2-d]pyrimid in-4-one
MW: 563.112 | Formula: C33H27ClN4OS
H donors: 0 H acceptors: 2 LogP: 7.13 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(cc1)c1cc2c(s1)c(=O)n(cn2)c1ccc2c(c1)ccc(n2)CN1CCC(CC1)c1ccccc1
InChi: 1S/C33H27ClN4OS/c34-26-9-6-24(7-10-26)31-19-30-32(40-31)33(39)38(21-35-30)28-12-13-29-25(18-28)8-11-27(36-29)20-37-16-14-23(15-17-37)22-4-2-1-3-5-22/h1-13,18-19,21,23H,14-17,20H2
InChiKey: ODMRZHCWTPHENJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

6-(4-chlorophenyl)-3-[2-[(4-phenyl-1-piperidyl)methyl]-6-quinolyl]thieno[3,2-d]pyrimidin-4-one
6-(4-chlorophenyl)-3-[2-[(4-phenyl-1-piperidinyl)methyl]-6-quinolyl]-4-thieno[3,2-d]pyrimidinone
6-(4-chlorophenyl)-3-[2-[(4-phenylpiperidino)methyl]-6-quinolyl]thieno[3,2-d]pyrimidin-4-one
6-(4-chlorophenyl)-3-[2-[(4-phenylpiperidin-1-yl)methyl]quinolin-6-yl]thieno[2,3-e]pyrimidin-4-one
6-(4-chlorophenyl)-3-[2-[(4-phenyl-1-piperidyl)methyl]-6-quinolyl]thieno[2,3-e]pyrimidin-4-one
6-(4-chlorophenyl)-3-[2-[(4-phenyl-1-piperidinyl)methyl]-6-quinolyl]-4-thieno[2,3-e]pyrimidinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.9652	1
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.9652	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.9652	0.9541
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Plasmodium vivax	unspecified product	0.0023	0.2712	0.2757
Onchocerca volvulus		0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0023	0.2712	0.281
Echinococcus granulosus	cathepsin L	0.0023	0.2712	0.041
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Mycobacterium leprae	OXIDATIVE STRESS RESPONSE REGULATORY PROTEIN OXYS	0.0014	0	0.5
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0023	0.2712	0.2757
Brugia malayi	Cathepsin L-like precursor	0.0029	0.492	0.5061
Loa Loa (eye worm)	ctsf protein	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0023	0.2712	0.2757
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0023	0.2712	0.281
Loa Loa (eye worm)	hypothetical protein	0.0029	0.492	0.5061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Toxoplasma gondii	cathepsin CPL	0.0044	0.9652	0.5
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Mycobacterium ulcerans	LuxR family transcriptional regulator	0.0014	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.492	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0044	0.9652	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.9652	1
Leishmania major	cysteine peptidase A (CPA)	0.0044	0.9652	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0044	0.9652	1
Entamoeba histolytica	cysteine protease, putative	0.0044	0.9652	1
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.492	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0044	0.9652	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.9652	0.9541
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LysR-family)	0.0014	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Plasmodium vivax	vivapain-2	0.0044	0.9652	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.492	0.5061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.9652	1
Brugia malayi	cathepsin L-like precursor	0.0029	0.492	0.5061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.9652	1
Plasmodium vivax	vivapain-2	0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.2712	0.2757
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus multilocularis	transfer RNA-Gly	0.0045	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.9652	0.9541
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Echinococcus multilocularis	cysteine protease	0.0044	0.9652	0.9541
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.9652	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0023	0.2712	0.281
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.2712	0.2757
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0029	0.492	0.5061
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0023	0.2712	0.2757
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.9652	1
Schistosoma mansoni	hypothetical protein	0.0022	0.2416	0.2503
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Loa Loa (eye worm)	fibroinase	0.0044	0.9652	1
Mycobacterium tuberculosis	Probable transcription regulator (LysR family)	0.0014	0	0.5
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Mycobacterium ulcerans	oxidative stress response regulatory protein OxyS	0.0014	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0029	0.492	0.5061
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.9652	1
Plasmodium vivax	vivapain-3	0.0023	0.2712	0.2757
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.9652	1
Onchocerca volvulus		0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.9652	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Mycobacterium ulcerans	LysR family transcriptional regulator	0.0014	0	0.5
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0029	0.492	0.5098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Echinococcus granulosus	cathepsin l1	0.0029	0.492	0.3461
Onchocerca volvulus		0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.492	0.5061
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.9652	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0044	0.9652	1
Mycobacterium leprae	Probable hydrogen peroxide-inducible genes activator OxyR	0.0014	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus granulosus	cysteine protease	0.0023	0.2712	0.041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0029	0.492	0.5061
Schistosoma mansoni	cathepsin s	0.0014	0.0071	0.0074
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.9652	0.9541
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Echinococcus multilocularis	transfer RNA-Gly	0.0045	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.9652	1
Plasmodium vivax	vivapain-1	0.0023	0.2712	0.2757
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0023	0.2712	0.041
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Mycobacterium ulcerans	LysR family transcriptional regulator	0.0014	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Loa Loa (eye worm)	cysteine protease	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Echinococcus granulosus	cathepsin l1	0.0044	0.9652	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.9652	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.9652	1
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.492	0.3182
Mycobacterium ulcerans	hydrogen peroxide-inducible genes activator, OxyR	0.0014	0	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0023	0.2712	0.2757
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.2712	0.2757
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Onchocerca volvulus		0.0044	0.9652	1
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LysR-family)	0.0014	0	0.5
Echinococcus multilocularis	cathepsin L	0.0023	0.2712	0.0391
Onchocerca volvulus		0.0044	0.9652	1
Echinococcus multilocularis	cysteine protease	0.0044	0.9652	0.9541
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.9652	1
Onchocerca volvulus		0.0044	0.9652	1
Echinococcus multilocularis	transfer RNA-Gly	0.0045	1	1
Mycobacterium tuberculosis	Oxidative stress response regulatory protein OxyS	0.0014	0	0.5
Echinococcus multilocularis	non capsid protein NS 1	0.0045	1	1
Onchocerca volvulus		0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.9652	1
Leishmania major	cathepsin L-like protease	0.0044	0.9652	0.5
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0044	0.9652	1
Echinococcus multilocularis	transfer RNA-Trp	0.0045	1	1
Mycobacterium ulcerans	putative regulatory protein	0.0014	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
CL (ADMET)	= 11 ml/min.kg	Total clearance in rat at 3 mg/kg, iv and 10 mg/kg, po	ChEMBL.	17125262
F (ADMET)	= 19 %	Oral bioavailability in rat at 3 mg/kg, iv and 10 mg/kg, po	ChEMBL.	17125262
IC50 (functional)	= 1.3 nM	Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay	ChEMBL.	17125262
IC50 (functional)	= 1.3 nM	Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay	ChEMBL.	17125262
T1/2 (ADMET)	= 8 hr	Half life in rat at 3 mg/kg, iv	ChEMBL.	17125262
Vss (ADMET)	= 4.3 L/Kg	Volume of distribution in rat at 3 mg/kg, iv and 10 mg/kg, po	ChEMBL.	17125262

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL217843
PubChem: 11993894

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 375601