Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.8277 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1075 | 0.0948 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.8277 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.8277 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4939 | 0.5805 | 0.9718 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1075 | 0.0948 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.8277 | 1 | 0.5 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0321 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.8277 | 1 | 0.5 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0321 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1075 | 0.0948 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0321 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.8277 | 1 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0321 | 0 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0321 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5074 | 0.5974 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.8277 | 1 | 0.5 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.5074 | 0.5974 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0321 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1075 | 0.0948 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1075 | 0.0948 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0321 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | > 50 % | Inhibition against HIV-1 integrase at 1 mM | ChEMBL. | 10841789 |
Inhibition (binding) | > 50 % | Inhibition against HIV-1 integrase at 200 microM | ChEMBL. | 10841789 |
Inhibition (binding) | > 50 % | Inhibition against HIV-1 integrase at 25 uM | ChEMBL. | 10841789 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.