Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.031 | 0.8874 | 1 |
Onchocerca volvulus | 0.0051 | 0.0991 | 1 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0234 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0234 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0234 | 0.0063 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0671 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0187 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0943 | 0.1246 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0187 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.031 | 0.8874 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0187 | 0.0211 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0187 | 0.0211 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0943 | 0.1024 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0671 | 1 |
Schistosoma mansoni | glutaminase | 0.0267 | 0.7571 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.031 | 0.8874 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0943 | 0.1246 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0621 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0187 | 0.0211 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0187 | 0.0211 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0187 | 0.0247 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.031 | 0.8874 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0234 | 0.0264 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.7571 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0187 | 0.0211 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.031 | 0.8874 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0671 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0991 | 0.131 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.031 | 0.8874 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0671 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0234 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.031 | 0.8874 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0187 | 0.0211 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0943 | 0.1024 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.7571 | 0.8531 |
Echinococcus multilocularis | tumor protein p63 | 0.0347 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.047 | 0.0383 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0991 | 0.0734 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0234 | 0.0264 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0187 | 0.0211 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0187 | 0.0211 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.7571 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0187 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0187 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0187 | 0.0247 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.031 | 0.8874 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0234 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0234 | 0.0264 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.7571 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0234 | 0.0309 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 0.7571 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0187 | 0.0247 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0671 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GHI (functional) | = 1.04 | In vitro GH release inhibiting potency on anterior pitutaries from adult male rats, relative to somatostatin | ChEMBL. | 7783129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.