TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 988.143 | Formula: C48H69N13O10
H donors: 12 H acceptors: 11 LogP: -1.16 Rotable bonds: 34
Rule of 5 violations (Lipinski): 4
SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)NC(c1ccccc1)C(=O)O)Cc1c[nH]cn1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N
InChi: 1S/C48H69N13O10/c1-6-28(4)39(45(68)57-35(23-31-24-52-26-54-31)46(69)61-21-11-15-36(61)43(66)60-40(47(70)71)30-12-8-7-9-13-30)59-42(65)34(22-29-16-18-32(62)19-17-29)56-44(67)38(27(2)3)58-41(64)33(55-37(63)25-51-5)14-10-20-53-48(49)50/h7-9,12-13,16-19,24,26-28,33-36,38-40,51,62H,6,10-11,14-15,20-23,25H2,1-5H3,(H,52,54)(H,55,63)(H,56,67)(H,57,68)(H,58,64)(H,59,65)(H,60,66)(H,70,71)(H4,49,50,53)/t28-,33-,34-,35-,36-,38-,39-,40?/m0/s1
InChiKey: FTRYLOUOYBMHJX-AMKNAZNASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	opsin-like receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	dro:myosuppressin receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0006	0.7508	0.7508
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0006	1	1
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptides capa receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	biogenic amine 5HT receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	G-protein coupled receptor	0.0006	0.7508	0.7508
Brugia malayi	G protein-coupled receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	cell adhesion molecule	0.0006	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptide receptor A26	0.0006	0.7508	0.7508
Echinococcus granulosus	G protein coupled receptor 139	0.0006	0.7508	0.7508
Echinococcus multilocularis	neuroglian	0.0006	1	1
Echinococcus granulosus	allatostatin A receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	g protein coupled receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	allatostatin A receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	fmrfamide receptor	0.0006	0.7508	0.7508
Brugia malayi	Dopamine receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	CAMK protein kinase	0.0006	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0006	0.7508	0.7508
Schistosoma mansoni	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	nephrin	0.0006	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	cell adhesion molecule	0.0006	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0006	0.7508	0.7508
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	1	1
Onchocerca volvulus		0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	titin	0.0006	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0006	0.7508	0.7508
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	opsin-like receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	serotonin receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	growth hormone secretagogue receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	hemicentin	0.0006	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	1	1
Schistosoma mansoni	neuropeptide receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	somatostatin receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	roundabout 2	0.0006	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	1	1
Schistosoma mansoni	amine GPCR	0.0006	0.7508	0.7508
Echinococcus multilocularis	fmrfamide receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	neuropeptides capa receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	ephrin receptor	0.0005	0.2459	0.2459
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Schistosoma mansoni	amine GPCR	0.0006	0.7508	0.7508
Schistosoma mansoni	neuropeptide receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0005	0.2459	0.2459
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	titin	0.0006	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	neuropeptide receptor A26	0.0006	0.7508	0.7508
Schistosoma mansoni	histamine h1 receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0006	0.7508	0.7508
Echinococcus multilocularis	neuropeptides capa receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	g protein coupled receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	7TM GPCR rhodopsin	0.0006	0.7508	0.7508
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0006	1	1
Brugia malayi	Melatonin receptor type 1A	0.0006	0.7508	0.7508
Echinococcus multilocularis	neuropeptide s receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0006	0.7508	0.7508
Echinococcus granulosus	titin	0.0006	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	roundabout 2	0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Echinococcus granulosus	biogenic amine 5HT receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0006	1	1
Onchocerca volvulus		0.0006	0.7508	0.7508
Brugia malayi	Dopamine receptor protein 2	0.0006	0.7508	0.7508
Schistosoma mansoni	amine GPCR	0.0006	0.7508	0.7508
Loa Loa (eye worm)	melatonin receptor type 1A	0.0006	0.7508	0.7508
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0006	0.7508	0.7508
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.7508	0.7508
Echinococcus multilocularis	neuropeptide receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0006	0.7508	0.7508
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Brugia malayi	Serotonin receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	fmrfamide receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	myosin xvIII	0.0006	0.7508	0.7508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptide receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.7508	0.7508
Brugia malayi	G protein-coupled receptor F59B2.13	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Schistosoma mansoni	neuropeptide F-like receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	myosin-binding protein-related	0.0006	1	1
Schistosoma mansoni	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0006	1	1
Schistosoma mansoni	amine GPCR	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0006	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.7508	0.7508
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0006	0.7508	0.7508
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	G protein coupled receptor 139	0.0006	0.7508	0.7508
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Schistosoma mansoni	neuroglian	0.0006	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0006	0.7508	0.7508
Brugia malayi	G-protein coupled receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0006	0.7508	0.7508
Brugia malayi	AKH receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	serotonin receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	opsin-like receptor	0.0006	0.7508	0.7508
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0006	0.7508	0.7508
Schistosoma mansoni	hypothetical protein	0.0006	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0006	1	1
Brugia malayi	ORL1-like opioid receptor	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	dro:myosuppressin receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.7508	0.7508
Loa Loa (eye worm)	TYRA-2 protein	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Schistosoma mansoni	nephrin	0.0006	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0006	0.7508	0.7508
Brugia malayi	Serotonin receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	nephrin	0.0006	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus multilocularis	serotonin receptor	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptide receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	amine GPCR	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Echinococcus granulosus	g-protein coupled receptor	0.0006	0.7508	0.7508
Brugia malayi	RE15519p	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptide s receptor	0.0006	0.7508	0.7508
Brugia malayi	larval opioid receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	transfer RNA-Phe	0.0006	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0006	0.7508	0.7508
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Echinococcus multilocularis	roundabout 2	0.0006	1	1
Schistosoma mansoni	titin	0.0006	1	1
Echinococcus multilocularis	titin	0.0006	1	1
Schistosoma mansoni	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	roundabout 2	0.0006	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0006	0.7508	0.7508
Echinococcus granulosus	neuroglian	0.0006	1	1
Echinococcus granulosus	contactin	0.0006	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Echinococcus multilocularis	roundabout 2	0.0006	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0006	0.7508	0.7508
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0006	0.7508	0.7508
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508
Schistosoma mansoni	neuropeptide receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0005	0.2459	0.2459
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	orexin receptor type 2	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptide Y receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptides capa receptor	0.0006	0.7508	0.7508
Brugia malayi	neuropeptide F receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	neuropeptide F receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.7508	0.7508
Schistosoma mansoni	cell adhesion molecule	0.0006	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.0006	0.7508	0.7508
Brugia malayi	putative neuropeptide receptor	0.0006	0.7508	0.7508
Brugia malayi	Dopamine receptor protein 1	0.0006	0.7508	0.7508
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0006	0.7508	0.7508
Brugia malayi	GnHR receptor homolog	0.0006	0.7508	0.7508
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0006	0.7508	0.7508
Brugia malayi	protein unc-22	0.0006	1	1
Loa Loa (eye worm)	projectin	0.0006	1	1
Onchocerca volvulus		0.0006	0.7508	0.7508
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0006	0.7508	0.7508
Echinococcus multilocularis	orexin receptor type 2	0.0006	0.7508	0.7508
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.7508	0.7508
Echinococcus multilocularis	somatostatin receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Brugia malayi	sulfakinin receptor protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.7508	0.7508
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Echinococcus multilocularis	sex peptide receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0006	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0006	0.7508	0.7508
Schistosoma mansoni	cell adhesion molecule	0.0006	1	1
Echinococcus granulosus	g protein coupled receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	neuropeptide receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	sex peptide receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	neuropeptide f receptor 76f	0.0006	0.7508	0.7508
Brugia malayi	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	roundabout 2	0.0006	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0006	0.7508	0.7508
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Schistosoma mansoni	biogenic amine receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	neuropeptide F-like receptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	1	1
Onchocerca volvulus		0.0006	0.7508	0.7508
Echinococcus granulosus	hypothetical protein	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptide Y receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0006	0.7508	0.7508
Echinococcus granulosus	neuropeptide FF receptor 2	0.0006	0.7508	0.7508
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.7508	0.7508
Schistosoma mansoni	adenoreceptor	0.0006	0.7508	0.7508
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0006	0.7508	0.7508
Echinococcus granulosus	7tm_1 domain containing protein	0.0006	0.7508	0.7508
Loa Loa (eye worm)	hypothetical protein	0.0006	0.7508	0.7508
Onchocerca volvulus		0.0006	0.7508	0.7508

Activities

Activity type	Activity value	Assay description	Source	Reference
Biological activity (functional)	0 %	AII-like activity, expressed as percent relative to AII(angiotensin II) was measured in the in vitro rabbit aorta strip assay; g = partial agonist at 10 ng/mL	ChEMBL.	3346871
Biological activity (functional)	0 %	In vivo AII-like activity, expressed as percent activity relative to AII(angiotensin II), measured in rat blood pressure assay; g = partial agonist at 10 ng/mL	ChEMBL.	3346871
pA2 (functional)	= 8.41	pA2 value was determined in the range of competitive inhibition in the in vitro rabbit aorta strip assay.	ChEMBL.	3346871

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 347741

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 404785