Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0093 | 0.4993 | 0.4993 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.008 | 0.4215 | 0.4215 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.119 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0093 | 0.4993 | 0.662 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4215 | 0.4215 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4215 | 0.4215 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0037 | 0.1729 | 0.1729 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.119 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4993 | 0.4993 |
Schistosoma mansoni | survival motor neuron protein | 0.0037 | 0.1729 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.018 | 1 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0138 | 0.7542 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0138 | 0.7542 | 0.7542 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4215 | 0.4215 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.018 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.119 | 0.6885 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.119 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0027 | 0.119 | 0.6885 |
Brugia malayi | hypothetical protein | 0.0027 | 0.119 | 0.119 |
Onchocerca volvulus | 0.0037 | 0.1729 | 0.2292 | |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.7542 | 0.7542 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0027 | 0.119 | 0.119 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4993 | 0.4993 |
Toxoplasma gondii | hypothetical protein | 0.008 | 0.4215 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0093 | 0.4993 | 0.662 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0027 | 0.119 | 0.119 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.119 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1729 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | > 5000 uM | Binding affinity to lipid A moiety of LPS in gram negative bacteria by fluorescent-based displacement assay | ChEMBL. | 17256835 |
IC50 (functional) | = 22.4 uM | Inhibition of LPS-induced NFkappaB production in HEK293 cells | ChEMBL. | 17256835 |
IC50 (functional) | = 22.4 uM | Inhibition of LPS-induced NFkappaB production in HEK293 cells | ChEMBL. | 17256835 |
IC50 (functional) | = 30.9 uM | Inhibition of LPS-induced nitric oxide production in murine J774.1 cells by automated Griess assay | ChEMBL. | 17256835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.