Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0112 | 0.5809 | 1 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 1 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.5809 | 0.5789 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0112 | 0.5809 | 1 |
Echinococcus granulosus | alpha13fucosyltransferase | 0.0048 | 0.1984 | 1 |
Onchocerca volvulus | 0.0167 | 0.9055 | 0.9684 | |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0217 | 0.0171 |
Loa Loa (eye worm) | fucosyl transferase | 0.0112 | 0.5809 | 0.5789 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0112 | 0.5809 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0047 | 0.0081 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.9286 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Echinococcus granulosus | Transcription initiation factor TFIID subunit | 0.0029 | 0.0864 | 0.4356 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0047 | 0.0237 |
Schistosoma mansoni | alpha 13/4 fucosyltransferase Lewis 1 | 0.0064 | 0.2987 | 0.5143 |
Echinococcus multilocularis | Transcription initiation factor TFIID subunit | 0.0029 | 0.0864 | 0.4356 |
Echinococcus multilocularis | alpha(13)fucosyltransferase | 0.0048 | 0.1984 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0112 | 0.5809 | 1 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0864 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0217 | 0.0171 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0019 | 0.0283 | 0.0486 |
Leishmania major | glycosyl transferase, putative | 0.0019 | 0.0283 | 0.5 |
Echinococcus multilocularis | alpha(13)fucosyltransferase | 0.0048 | 0.1984 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0112 | 0.5809 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1984 | 0.1946 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0217 | 0.1096 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0217 | 0.1096 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0048 | 0.1984 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0019 | 0.0283 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0019 | 0.0283 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.