Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0844 | 0.1796 | 0.7873 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.374 | 0.8413 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1966 | 0.4359 | 0.5177 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1643 | 0.3622 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1966 | 0.4359 | 0.5177 |
Entamoeba histolytica | ankyrin, putative | 0.0076 | 0.0042 | 0.0000000090764 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0171 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0097 | 0.0104 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1571 | 0.3456 | 0.954 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.374 | 0.8413 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1643 | 0.3622 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0749 | 0.1578 | 0.1866 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1966 | 0.4359 | 0.5177 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1966 | 0.4359 | 0.5177 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0256 | 0.0452 | 0.195 |
Leishmania major | carbonic anhydrase-like protein | 0.374 | 0.8413 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1966 | 0.4359 | 0.5177 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0076 | 0.0042 | 0.0141 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.0171 | 0.3242 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.374 | 0.8413 | 0.8413 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.374 | 0.8413 | 0.5 |
Onchocerca volvulus | 0.0222 | 0.0374 | 0.8072 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.374 | 0.8413 | 1 |
Echinococcus granulosus | dynactin 5 p25 | 0.0076 | 0.0042 | 0.0038 |
Onchocerca volvulus | Putative sulfate transporter | 0.0222 | 0.0374 | 0.8072 |
Trichomonas vaginalis | set domain proteins, putative | 0.0257 | 0.0454 | 0.1169 |
Echinococcus granulosus | carbonic anhydrase | 0.1966 | 0.4359 | 0.5177 |
Brugia malayi | Pre-SET motif family protein | 0.0226 | 0.0383 | 0.0445 |
Echinococcus multilocularis | carbonic anhydrase | 0.1966 | 0.4359 | 0.5177 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.374 | 0.8413 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1966 | 0.4359 | 0.4359 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0256 | 0.0452 | 0.1219 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1966 | 0.4359 | 0.5177 |
Echinococcus granulosus | carbonic anhydrase II | 0.374 | 0.8413 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1966 | 0.4359 | 0.5177 |
Onchocerca volvulus | 0.0257 | 0.0454 | 1 | |
Leishmania major | carbonic anhydrase family protein, putative | 0.1571 | 0.3456 | 0.4101 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0076 | 0.0042 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1966 | 0.4359 | 0.5177 |
Toxoplasma gondii | hypothetical protein | 0.1966 | 0.4359 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1966 | 0.4359 | 0.5177 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1055 | 0.2278 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1966 | 0.4359 | 0.5177 |
Schistosoma mansoni | carbonic anhydrase | 0.1571 | 0.3456 | 0.4101 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0226 | 0.0383 | 0.0383 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.009 | 0.0073 | 0.0076 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.374 | 0.8413 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1571 | 0.3456 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.0171 | 0.3242 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0749 | 0.1578 | 0.1866 |
Schistosoma mansoni | carbonic anhydrase | 0.1966 | 0.4359 | 0.5177 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.374 | 0.8413 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0749 | 0.1578 | 0.1866 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.009 | 0.0073 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.1966 | 0.4359 | 0.4359 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.009 | 0.0073 | 0.0076 |
Echinococcus granulosus | Desert hedgehog protein | 0.0138 | 0.0182 | 0.0205 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1571 | 0.3456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0171 | 0.0171 |
Onchocerca volvulus | 0.009 | 0.0073 | 0.0916 | |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.009 | 0.0073 | 0.0076 |
Echinococcus granulosus | carbonic anhydrase | 0.1966 | 0.4359 | 0.5177 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.374 | 0.8413 | 0.8413 |
Brugia malayi | hypothetical protein | 0.0133 | 0.0171 | 0.0192 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1643 | 0.3622 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.374 | 0.8413 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1966 | 0.4359 | 0.4359 |
Echinococcus multilocularis | carbonic anhydrase | 0.1966 | 0.4359 | 0.5177 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0073 | 0.0073 |
Plasmodium falciparum | carbonic anhydrase | 0.1966 | 0.4359 | 0.5 |
Mycobacterium ulcerans | transferase | 0.0073 | 0.0035 | 0.0071 |
Echinococcus multilocularis | hedgehog | 0.0138 | 0.0182 | 0.0205 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0076 | 0.0042 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0983 | 0.2112 | 0.9267 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1966 | 0.4359 | 0.5177 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.