Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0069 | 0.2485 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0088 | 0.0155 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0088 | 0.0155 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0078 | 0.2893 | 0.5068 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0088 | 0.0109 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0088 | 0.0109 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.1369 | 0.1369 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0088 | 0.0155 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0088 | 0.0155 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0088 | 0.0109 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0136 | 0.5708 | 0.7002 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0136 | 0.5708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0044 | 0.0054 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0048 | 0.1445 | 0.2532 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0088 | 0.0109 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0088 | 0.0109 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0088 | 0.0155 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0136 | 0.5708 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0088 | 0.0155 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0088 | 0.0109 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0088 | 0.0155 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0088 | 0.0109 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0088 | 0.0155 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0078 | 0.2893 | 0.5068 |
Brugia malayi | Plexin repeat family protein | 0.0019 | 0.0044 | 0.0054 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0088 | 0.0109 |
Schistosoma mansoni | transmemberane protein | 0.0078 | 0.2893 | 0.5068 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0088 | 0.0109 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0136 | 0.5708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0088 | 0.0109 |
Echinococcus multilocularis | plexin a4 | 0.0022 | 0.0211 | 0.0369 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0088 | 0.0155 |
Plasmodium vivax | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | NAD-dependent deacetylase 1, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0088 | 0.0109 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0088 | 0.0109 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0088 | 0.0155 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0088 | 0.0109 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0069 | 0.2485 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0136 | 0.5708 | 1 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0088 | 0.0155 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0046 | 0.1369 | 0.1369 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0078 | 0.2893 | 0.5068 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0088 | 0.0155 |
Brugia malayi | plexin A | 0.0022 | 0.0211 | 0.0258 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0088 | 0.0109 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0088 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0088 | 0.0109 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0078 | 0.2893 | 0.5068 |
Echinococcus multilocularis | nervana 2 | 0.0048 | 0.1445 | 0.2532 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0088 | 0.0109 |
Echinococcus granulosus | plexin a4 | 0.0022 | 0.0211 | 0.0369 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0155 | 0.6651 | 0.6651 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0088 | 0.0155 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0088 | 0.0109 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0136 | 0.5708 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.1369 | 0.1369 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0088 | 0.0109 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0088 | 0.0109 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0088 | 0.0155 |
Toxoplasma gondii | hypothetical protein | 0.0053 | 0.1697 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0088 | 0.0109 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0088 | 0.0109 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0078 | 0.2893 | 0.5068 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0048 | 0.1445 | 0.2532 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0078 | 0.2893 | 0.5068 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0088 | 0.0155 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0056 | 0.1857 | 0.1857 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.0088 | 0.0055 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0136 | 0.5708 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0048 | 0.1445 | 0.2532 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0088 | 0.0155 |
Echinococcus granulosus | nervana 2 | 0.0048 | 0.1445 | 0.2532 |
Echinococcus multilocularis | nervana 2 | 0.0078 | 0.2893 | 0.5068 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.0088 | 0.0055 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0088 | 0.0155 |
Loa Loa (eye worm) | plexin A | 0.0022 | 0.0211 | 0.0258 |
Onchocerca volvulus | 0.002 | 0.0088 | 0.0055 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0088 | 0.0109 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0186 | 0.8151 | 1 |
Schistosoma mansoni | plexin | 0.0019 | 0.0044 | 0.0078 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0088 | 0.0155 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0088 | 0.0109 |
Onchocerca volvulus | 0.0078 | 0.2893 | 0.3514 | |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0088 | 0.0155 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0088 | 0.0155 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0088 | 0.0109 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0048 | 0.1445 | 0.2532 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0088 | 0.0155 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0088 | 0.0109 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0088 | 0.0155 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0088 | 0.0155 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0088 | 0.0155 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0078 | 0.2893 | 0.5068 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0088 | 0.0109 |
Echinococcus granulosus | nervana 2 | 0.0078 | 0.2893 | 0.5068 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0088 | 0.0109 |
Onchocerca volvulus | 0.0048 | 0.1445 | 0.1728 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0088 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2893 | 0.3549 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0078 | 0.2893 | 0.5068 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0224 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0088 | 0.0109 |
Brugia malayi | ecdysteroid receptor | 0.0186 | 0.8151 | 1 |
Echinococcus granulosus | nervana 2 | 0.0078 | 0.2893 | 0.5068 |
Echinococcus granulosus | nervana 2 | 0.0048 | 0.1445 | 0.2532 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0088 | 0.0109 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0088 | 0.0109 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0155 | 0.6651 | 0.6651 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0088 | 0.0109 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0088 | 0.0155 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0136 | 0.5708 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0088 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.8151 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0224 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0155 | 0.6651 | 0.6651 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0088 | 0.0155 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0088 | 0.0155 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0088 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2893 | 0.3549 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0046 | 0.1369 | 0.1369 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0088 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.5708 | 0.7002 |
Echinococcus multilocularis | nervana 2 | 0.0078 | 0.2893 | 0.5068 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0136 | 0.5708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.4844 | 0.5942 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0088 | 0.0109 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0048 | 0.1445 | 0.2532 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0088 | 0.0109 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.