Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 9 | Starlite/ChEMBL | References |
Rattus norvegicus | Dipeptidyl peptidase IV | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 637 aa | 27.0 % | |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 789 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0559 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0066 | 0.0739 | 0.0739 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0416 | 0.7306 | 1 |
Plasmodium falciparum | peptidase, putative | 0.0066 | 0.0739 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0739 | 0.0739 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0559 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0066 | 0.0739 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0066 | 0.0739 | 0.00000019198 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0066 | 0.0739 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0416 | 0.7306 | 0.7092 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0066 | 0.0739 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0739 | 0.0739 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0559 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0416 | 0.7306 | 0.7306 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0066 | 0.0739 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0416 | 0.7306 | 0.7306 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0066 | 0.0739 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0066 | 0.0739 | 0.5 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0066 | 0.0739 | 0.0739 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0066 | 0.0739 | 0.00000019198 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0416 | 0.7306 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0416 | 0.7306 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0066 | 0.0739 | 0.5 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0066 | 0.0739 | 0.0739 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0281 | 0.478 | 1 |
Brugia malayi | hypothetical protein | 0.0215 | 0.3533 | 0.3533 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0066 | 0.0739 | 0.0739 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0066 | 0.0739 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0066 | 0.0739 | 0.0739 |
Mycobacterium tuberculosis | Probable peptidase | 0.0066 | 0.0739 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0066 | 0.0739 | 0.0739 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0066 | 0.0739 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0066 | 0.0739 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0416 | 0.7306 | 0.7306 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0416 | 0.7306 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0066 | 0.0739 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.3265 | 0.3265 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0559 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0416 | 0.7306 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0066 | 0.0739 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0066 | 0.0739 | 0.00000013615 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0066 | 0.0739 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0559 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.3533 | 0.3533 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0066 | 0.0739 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0066 | 0.0739 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0066 | 0.0739 | 0.0739 |
Echinococcus granulosus | prolyl endopeptidase | 0.0066 | 0.0739 | 0.0739 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nmol/L | Inhibition of DPP4 in human plasma by fluorescence assay | ChEMBL. | 17113301 |
IC50 (binding) | = 11 nmol/L | Inhibition of DPP4 in human plasma by fluorescence assay | ChEMBL. | 17113301 |
IC50 (binding) | = 19.5 nmol/L | Inhibition of DPP4 in rat plasma by fluorescence assay | ChEMBL. | 17113301 |
IC50 (binding) | = 19.5 nmol/L | Inhibition of DPP4 in rat plasma by fluorescence assay | ChEMBL. | 17113301 |
IC50 (binding) | = 501.1 nmol/L | Inhibition of human recombinant DPP9 | ChEMBL. | 17113301 |
IC50 (binding) | = 501.1 nmol/L | Inhibition of human recombinant DPP9 | ChEMBL. | 17113301 |
IC50 (binding) | = 736.5 nmol/L | Inhibition of human recombinant DPP8 | ChEMBL. | 17113301 |
IC50 (binding) | = 736.5 nmol/L | Inhibition of human recombinant DPP8 | ChEMBL. | 17113301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.