Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0092 | 0.402 | 0.4022 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0115 | 0.5673 | 0.3512 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0092 | 0.402 | 0.4022 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.605 | 0.6053 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3927 | 0.0892 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0175 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0092 | 0.402 | 0.4022 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0092 | 0.402 | 0.4022 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0175 | 0.9996 | 1 |
Schistosoma mansoni | protein phosphatase-2b | 0.0092 | 0.402 | 0.402 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.605 | 0.4078 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 0.9996 | 1 |
Plasmodium falciparum | plasmepsin IX | 0.0108 | 0.5127 | 0.2693 |
Entamoeba histolytica | Ser/Thr protein phosphatase, putative | 0.0092 | 0.402 | 0.4022 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.402 | 0.1032 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0175 | 0.9996 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0175 | 0.9996 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0175 | 0.9996 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0175 | 0.9996 | 1 |
Giardia lamblia | CDC72 | 0.0175 | 0.9996 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 0.9996 | 1 |
Toxoplasma gondii | protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein | 0.0092 | 0.402 | 0.3833 |
Entamoeba histolytica | Ser/Thr protein phosphatase, putative | 0.0092 | 0.402 | 0.4022 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0175 | 0.9996 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0175 | 0.9996 | 0.9996 |
Trypanosoma brucei | N-myristoyltransferase | 0.0175 | 0.9996 | 1 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0108 | 0.5127 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.0175 | 0.9996 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.605 | 0.4078 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0092 | 0.402 | 0.4022 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0083 | 0.3332 | 0.3334 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0175 | 0.9996 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0083 | 0.3332 | 0.3334 |
Schistosoma mansoni | protein phosphatase-2b | 0.0092 | 0.402 | 0.402 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0092 | 0.402 | 0.4022 |
Plasmodium vivax | aspartyl protease, putative | 0.0108 | 0.5127 | 0.2693 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0175 | 0.9996 | 1 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0092 | 0.402 | 0.4022 |
Plasmodium vivax | aspartyl protease, putative | 0.0108 | 0.5127 | 0.2693 |
Plasmodium falciparum | serine/threonine protein phosphatase 2B catalytic subunit A | 0.0092 | 0.402 | 0.1032 |
Plasmodium falciparum | plasmepsin X | 0.0108 | 0.5127 | 0.2693 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0083 | 0.3332 | 0.3332 |
Brugia malayi | Serine/threonine protein phosphatase 2B catalytic subunit 2 | 0.0092 | 0.402 | 0.4022 |
Leishmania major | N-myristoyl transferase, putative | 0.0175 | 0.9996 | 1 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0092 | 0.402 | 0.4022 |
Plasmodium vivax | serine/threonine protein phosphatase 2B catalytic subunit A, putative | 0.0092 | 0.402 | 0.1032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.367 | Cytotoxicity against human MDA-MB-231 cells | ChEMBL. | 19167135 |
IC50 (functional) | = 22 nM | Antiproliferative activity against human MCF7 cells after 5 days | ChEMBL. | 17533132 |
IC50 (functional) | = 22 nM | Antiproliferative activity against human MCF7 cells after 5 days | ChEMBL. | 17533132 |
IC50 (functional) | = 43 nM | Antiproliferative activity against human MDA-MB-231 cells after 4 days | ChEMBL. | 17533132 |
IC50 (functional) | = 43 nM | Antiproliferative activity against human MDA-MB-231 cells after 4 days | ChEMBL. | 17533132 |
IC50 (functional) | = 43 nM | Cytotoxicity against human MDA-MB-231 cells | ChEMBL. | 19167135 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17533132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.