Detailed information for compound 429691

Basic information

Technical information
  • TDR Targets ID: 429691
  • Name: N-[1-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin -7-yl)-1-methyl-ethyl]-2-fluoro-9-oxo-10H-acr idine-3-carboxamide
  • MW: 432.447 | Formula: C24H21FN4O3
  • H donors: 3 H acceptors: 3 LogP: 3.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc2[nH]c3ccccc3c(=O)c2cc1F)NC(c1cnc2c(c1)OCCN2)(C)C
  • InChi: 1S/C24H21FN4O3/c1-24(2,13-9-20-22(27-12-13)26-7-8-32-20)29-23(31)15-11-19-16(10-17(15)25)21(30)14-5-3-4-6-18(14)28-19/h3-6,9-12H,7-8H2,1-2H3,(H,26,27)(H,28,30)(H,29,31)
  • InChiKey: SOGONSJMRDJQLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-1-methylethyl]-2-fluoro-9-oxo-10H-acridine-3-carboxamide
  • N-[1-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-1-methyl-ethyl]-2-fluoro-9-keto-10H-acridine-3-carboxamide
  • N-[1-(3,4-dihydro-2H-pyrido[5,6-b][1,4]oxazin-7-yl)-1-methyl-ethyl]-2-fluoro-9-oxo-10H-acridine-3-carboxamide
  • N-[1-(3,4-dihydro-2H-pyrido[5,6-b][1,4]oxazin-7-yl)-1-methylethyl]-2-fluoro-9-oxo-10H-acridine-3-carboxamide
  • N-[1-(3,4-dihydro-2H-pyrido[5,6-b][1,4]oxazin-7-yl)-1-methyl-ethyl]-2-fluoro-9-keto-10H-acridine-3-carboxamide
  • N-[2-(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)propan-2-yl]-2-fluoro-9-oxo-10H-acridine-3-carboxamide
  • N-[2-(3,4-dihydro-2H-pyrido[5,6-b][1,4]oxazin-7-yl)propan-2-yl]-2-fluoro-9-oxo-10H-acridine-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0095 0.2946 1
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.2043 0.6867
Brugia malayi putative neuropeptide receptor 0.0068 0.2043 0.1992
Echinococcus multilocularis fmrfamide receptor 0.0068 0.2043 0.6867
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 0.2043 0.1992
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0933 0.3016
Onchocerca volvulus 0.0301 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.2043 0.1992
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0301 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.2043 0.6867
Schistosoma mansoni biogenic amine receptor 0.0068 0.2043 0.6867
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.2043 0.6867
Echinococcus granulosus neuropeptide receptor 0.0068 0.2043 0.6867
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.2043 0.6867
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Schistosoma mansoni opsin-like receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.2043 0.6867
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.1055 0.0997
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.2043 0.6867
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.2043 0.6867
Brugia malayi Serotonin receptor 0.0068 0.2043 0.1992
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Brugia malayi larval opioid receptor 0.0068 0.2043 0.1992
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.2043 0.6867
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.1046 0.3406
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.2043 0.6867
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.2043 0.6867
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.2043 0.1992
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.2043 0.6867
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.2043 0.2043
Trypanosoma brucei GMP reductase 0.0095 0.2946 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0933 0.3016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Echinococcus multilocularis somatostatin receptor 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Echinococcus granulosus g protein coupled receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.2043 0.6867
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0117 0.0117
Brugia malayi neuropeptide F receptor 0.0068 0.2043 0.1992
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Echinococcus granulosus g-protein coupled receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.2043 0.6867
Brugia malayi G-protein coupled receptor 0.0068 0.2043 0.1992
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni amine GPCR 0.0068 0.2043 0.6867
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.2043 0.1992
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni amine GPCR 0.0068 0.2043 0.6867
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.2043 0.6867
Brugia malayi G protein-coupled receptor 0.0068 0.2043 0.1992
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.2043 0.6867
Brugia malayi AKH receptor 0.0068 0.2043 0.1992
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.2946 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.2043 0.6867
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.2043 0.6867
Echinococcus granulosus neuropeptide receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.2043 0.6867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.2043 0.6867
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0933 0.0875
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0095 0.2946 1
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.2043 0.1992
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.2043 0.6867
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.2043 0.2043
Echinococcus multilocularis g protein coupled receptor 0.0068 0.2043 0.6867
Schistosoma mansoni neuropeptide receptor 0.0068 0.2043 0.6867
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.2043 0.6867
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0095 0.2946 0.2901
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.2043 0.6867
Echinococcus granulosus somatostatin receptor 0.0068 0.2043 0.6867
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0089 0.2754 0.5
Echinococcus granulosus fmrfamide receptor 0.0068 0.2043 0.6867
Onchocerca volvulus 0.0068 0.2043 0.1105
Brugia malayi Cytochrome P450 family protein 0.0012 0.0117 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0095 0.2946 1
Schistosoma mansoni hypothetical protein 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Brugia malayi Serotonin receptor 0.0068 0.2043 0.1992
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.2043 0.6867
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni neuropeptide receptor 0.0068 0.2043 0.6867
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0045 0.1247 0.3992
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) IMP dehydrogenase 1 0.0095 0.2946 0.2946
Echinococcus multilocularis neuropeptide receptor 0.0068 0.2043 0.6867
Brugia malayi Dopamine receptor protein 1 0.0068 0.2043 0.1992
Echinococcus granulosus hypothetical protein 0.0068 0.2043 0.6867
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0095 0.2946 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.2043 0.6867
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0933 0.0933
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 0.2043 0.6867
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.2043 0.6867
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.2043 0.1105
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni opsin-like receptor 0.0068 0.2043 0.6867
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Schistosoma mansoni amine GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus multilocularis orexin receptor type 2 0.0068 0.2043 0.6867
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0095 0.2946 1
Schistosoma mansoni hypothetical protein 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) GMP reductase 0.0039 0.1055 0.1055
Brugia malayi Dopamine receptor 0.0068 0.2043 0.1992
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Trypanosoma cruzi GMP reductase 0.0095 0.2946 1
Brugia malayi GMP reductase 0.0039 0.1055 0.0997
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.2043 0.6867
Leishmania major inosine-5-monophosphate dehydrogenase 0.0095 0.2946 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.2043 0.6867
Schistosoma mansoni opsin-like receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.2043 0.2043
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0853 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Brugia malayi GnHR receptor homolog 0.0068 0.2043 0.1992
Onchocerca volvulus 0.0068 0.2043 0.1105
Schistosoma mansoni histamine h1 receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis fmrfamide receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0117 0.0117
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.2043 0.6867
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.2043 0.6867
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Onchocerca volvulus 0.0068 0.2043 0.1105
Schistosoma mansoni neuropeptide receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.2043 0.6867
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.2043 0.1105
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.2043 0.2043
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.2043 0.6867
Schistosoma mansoni myosin xvIII 0.0068 0.2043 0.6867
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Schistosoma mansoni amine GPCR 0.0068 0.2043 0.6867
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.2043 0.6867
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.2043 0.6867
Schistosoma mansoni amine GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0031 0.0772 0.0772
Echinococcus granulosus orexin receptor type 2 0.0068 0.2043 0.6867
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.2043 0.6867
Onchocerca volvulus 0.0068 0.2043 0.1105
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0089 0.2754 0.9321
Brugia malayi Melatonin receptor type 1A 0.0068 0.2043 0.1992
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.005 0.1409 0.0954
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.2043 0.6867
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.2946 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.2946 1
Onchocerca volvulus 0.0068 0.2043 0.1105
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.2043 0.2043
Onchocerca volvulus 0.0068 0.2043 0.1105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.001 0.0064 0.0064
Toxoplasma gondii IMP dehydrogenas 0.0095 0.2946 0.5
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0095 0.2946 1
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.2043 0.6867
Echinococcus granulosus g protein coupled receptor 0.0068 0.2043 0.6867
Brugia malayi neuropeptide F receptor 0.0068 0.2043 0.1992
Brugia malayi follicle stimulating hormone receptor 0.0068 0.2043 0.1992
Echinococcus granulosus allatostatin A receptor 0.0068 0.2043 0.6867
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.2043 0.2043
Brugia malayi RE15519p 0.0068 0.2043 0.1992
Trypanosoma cruzi GMP reductase 0.0095 0.2946 1
Echinococcus granulosus g protein coupled receptor 0.0068 0.2043 0.6867
Schistosoma mansoni biogenic amine receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0117 0.0117
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.2043 0.2043
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.2043 0.2043
Echinococcus multilocularis neuropeptide receptor 0.0068 0.2043 0.6867
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.2043 0.6867
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.1055 0.0997
Echinococcus granulosus neuropeptide s receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.2043 0.6867
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Brugia malayi G-protein coupled receptor 0.0068 0.2043 0.1992
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.2043 0.6867
Echinococcus multilocularis sex peptide receptor 0.0068 0.2043 0.6867
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.2043 0.1992
Echinococcus multilocularis serotonin receptor 0.0068 0.2043 0.6867
Echinococcus granulosus sex peptide receptor 0.0068 0.2043 0.6867
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.2043 0.1992
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.2043 0.6867
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0853 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.2043 0.2043
Echinococcus multilocularis g protein coupled receptor 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Onchocerca volvulus 0.0068 0.2043 0.1105
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.2043 0.6867
Brugia malayi ORL1-like opioid receptor 0.0068 0.2043 0.1992
Schistosoma mansoni hypothetical protein 0.0068 0.2043 0.6867
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Schistosoma mansoni adenoreceptor 0.0068 0.2043 0.6867
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.2043 0.6867
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.2043 0.6867
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0095 0.2946 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.2043 0.6867
Brugia malayi Dopamine receptor protein 2 0.0068 0.2043 0.1992
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0089 0.2754 0.5
Brugia malayi Cytochrome P450 family protein 0.0012 0.0117 0.0054
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0095 0.2946 0.5
Onchocerca volvulus 0.0068 0.2043 0.1105
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.2043 0.6867
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.2043 0.6867
Brugia malayi sulfakinin receptor protein 0.0068 0.2043 0.1992
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.2043 0.6867
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus multilocularis g protein coupled receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.2043 0.6867
Schistosoma mansoni neuropeptide receptor 0.0068 0.2043 0.6867
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.2043 0.1992
Brugia malayi hypothetical protein 0.0068 0.2043 0.1992
Schistosoma mansoni biogenic amine receptor 0.0068 0.2043 0.6867
Onchocerca volvulus 0.0068 0.2043 0.1105
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.2043 0.6867
Schistosoma mansoni hypothetical protein 0.0068 0.2043 0.6867
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.2043 0.2043
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.1046 0.3406
Onchocerca volvulus 0.0068 0.2043 0.1105
Loa Loa (eye worm) hypothetical protein 0.0068 0.2043 0.2043
Echinococcus granulosus serotonin receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis allatostatin A receptor 0.0068 0.2043 0.6867
Echinococcus multilocularis serotonin receptor 0.0068 0.2043 0.6867
Leishmania major guanosine monophosphate reductase 0.0095 0.2946 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.2043 0.6867

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 nM Inhibition of human IMPDH2 ChEMBL. 17585753
IC50 (binding) = 17 nM Inhibition of human IMPDH2 ChEMBL. 17585753
IC50 (functional) = 0.32 uM Inhibition of T cell proliferation in PBMC cells ChEMBL. 17585753
IC50 (functional) = 0.32 uM Inhibition of T cell proliferation in PBMC cells ChEMBL. 17585753
IC50 (functional) = 0.92 uM Inhibition of CEM cell proliferation ChEMBL. 17585753
IC50 (functional) = 0.92 uM Inhibition of CEM cell proliferation ChEMBL. 17585753

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17585753

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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