Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | casein kinase 2, alpha 1 polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | casein kinase II, alpha chain, putative | casein kinase 2, alpha 1 polypeptide | 391 aa | 316 aa | 51.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | amidase, putative | 0.0244 | 0.0839 | 0.2008 |
Loa Loa (eye worm) | amidase | 0.0244 | 0.0839 | 0.0839 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0244 | 0.0839 | 0.0839 |
Mycobacterium ulcerans | amidase | 0.0244 | 0.0839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2024 | 1 | 1 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0244 | 0.0839 | 0.0839 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0892 | 0.4175 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0244 | 0.0839 | 0.0839 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0244 | 0.0839 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0244 | 0.0839 | 0.2008 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0244 | 0.0839 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0081 | 0 | 0.5 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0244 | 0.0839 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0244 | 0.0839 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0244 | 0.0839 | 0.0839 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0081 | 0 | 0.5 |
Brugia malayi | putative amidase | 0.0244 | 0.0839 | 0.0839 |
Mycobacterium ulcerans | amidase | 0.0244 | 0.0839 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0892 | 0.4175 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0892 | 0.4175 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2024 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0244 | 0.0839 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0081 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0892 | 0.4175 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2024 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0244 | 0.0839 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0892 | 0.4175 | 1 |
Mycobacterium ulcerans | amidase | 0.0244 | 0.0839 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0081 | 0 | 0.5 |
Loa Loa (eye worm) | amidase | 0.0244 | 0.0839 | 0.0839 |
Brugia malayi | Lipase family protein | 0.0892 | 0.4175 | 0.4175 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0244 | 0.0839 | 1 |
Onchocerca volvulus | 0.0892 | 0.4175 | 0.5 | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2024 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2024 | 1 | 1 |
Brugia malayi | Amidase family protein | 0.0244 | 0.0839 | 0.0839 |
Mycobacterium ulcerans | amidase | 0.0244 | 0.0839 | 1 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0244 | 0.0839 | 0.2008 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.2024 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0244 | 0.0839 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0892 | 0.4175 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0244 | 0.0839 | 1 |
Schistosoma mansoni | amidase | 0.2024 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0244 | 0.0839 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0892 | 0.4175 | 0.4175 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0244 | 0.0839 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0892 | 0.4175 | 0.4175 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0244 | 0.0839 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0244 | 0.0839 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0892 | 0.4175 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0244 | 0.0839 | 0.2008 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0244 | 0.0839 | 0.0839 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0244 | 0.0839 | 0.0839 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0244 | 0.0839 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0892 | 0.4175 | 0.4175 |
Brugia malayi | Amidase family protein | 0.0244 | 0.0839 | 0.0839 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0244 | 0.0839 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.