Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | amidase | 0.0253 | 0.0517 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0875 | 0.3724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2094 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.0253 | 0.0517 | 1 |
Loa Loa (eye worm) | lipase | 0.0875 | 0.3724 | 0.3724 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0253 | 0.0517 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0253 | 0.0517 | 0.139 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2094 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0875 | 0.3724 | 0.3724 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0253 | 0.0517 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2094 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0253 | 0.0517 | 0.0517 |
Trypanosoma brucei | lipase domain protein, putative | 0.0875 | 0.3724 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.2094 | 1 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0253 | 0.0517 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0253 | 0.0517 | 0.139 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0253 | 0.0517 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.2094 | 1 | 1 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0253 | 0.0517 | 0.0517 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0253 | 0.0517 | 0.139 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0875 | 0.3724 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0253 | 0.0517 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0875 | 0.3724 | 0.3724 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0875 | 0.3724 | 0.5 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0253 | 0.0517 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0253 | 0.0517 | 1 |
Brugia malayi | Amidase family protein | 0.0253 | 0.0517 | 0.0517 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0253 | 0.0517 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0875 | 0.3724 | 0.3724 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0253 | 0.0517 | 0.0517 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0253 | 0.0517 | 1 |
Brugia malayi | putative amidase | 0.0253 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | amidase | 0.0253 | 0.0517 | 0.0517 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0253 | 0.0517 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0875 | 0.3724 | 1 |
Schistosoma mansoni | amidase | 0.2094 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0253 | 0.0517 | 0.5 |
Trypanosoma cruzi | amidase, putative | 0.0253 | 0.0517 | 0.139 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0253 | 0.0517 | 1 |
Loa Loa (eye worm) | amidase | 0.0253 | 0.0517 | 0.0517 |
Brugia malayi | Amidase family protein | 0.0253 | 0.0517 | 0.0517 |
Mycobacterium ulcerans | amidase | 0.0253 | 0.0517 | 1 |
Mycobacterium ulcerans | amidase | 0.0253 | 0.0517 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0253 | 0.0517 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0253 | 0.0517 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.2094 | 1 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0253 | 0.0517 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0875 | 0.3724 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0875 | 0.3724 | 1 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0253 | 0.0517 | 0.0517 |
Onchocerca volvulus | 0.0875 | 0.3724 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.