Detailed information for compound 432863

Basic information

Technical information
  • TDR Targets ID: 432863
  • Name: oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,1 1,14-tetraenoate
  • MW: 360.53 | Formula: C23H36O3
  • H donors: 0 H acceptors: 1 LogP: 6.31 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OCC1CO1
  • InChi: 1S/C23H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(24)26-21-22-20-25-22/h6-7,9-10,12-13,15-16,22H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
  • InChiKey: ACYNJBAUKQMZDF-DOFZRALJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid 2-oxiranylmethyl ester
  • (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid glycidyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Monoglyceride lipase Starlite/ChEMBL References
Rattus norvegicus Anandamide amidohydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase Monoglyceride lipase   303 aa 250 aa 21.2 %
Plasmodium falciparum esterase, putative Monoglyceride lipase   303 aa 265 aa 21.5 %
Plasmodium vivax hypothetical protein, conserved Monoglyceride lipase   303 aa 282 aa 20.6 %
Plasmodium vivax PST-A protein Monoglyceride lipase   303 aa 261 aa 24.1 %
Plasmodium falciparum epoxide hydrolase 2 Monoglyceride lipase   303 aa 254 aa 22.4 %
Echinococcus multilocularis fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.3 %
Candida albicans similar to S. cerevisiae YOR084W Monoglyceride lipase   303 aa 303 aa 23.4 %
Neospora caninum Lysophospholipase, related Monoglyceride lipase   303 aa 380 aa 21.1 %
Plasmodium vivax lysophospholipase, putative Monoglyceride lipase   303 aa 274 aa 23.4 %
Plasmodium knowlesi esterase, putative Monoglyceride lipase   303 aa 259 aa 25.5 %
Trypanosoma brucei Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative Monoglyceride lipase   303 aa 276 aa 23.2 %
Plasmodium vivax lysophospholipase, putative Monoglyceride lipase   303 aa 361 aa 21.6 %
Toxoplasma gondii phospholipase Monoglyceride lipase   303 aa 378 aa 20.9 %
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative Monoglyceride lipase   303 aa 245 aa 23.3 %
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Anandamide amidohydrolase   579 aa 499 aa 24.6 %
Leishmania braziliensis hypothetical protein, conserved Monoglyceride lipase   303 aa 250 aa 24.8 %
Plasmodium falciparum esterase, putative Monoglyceride lipase   303 aa 273 aa 19.0 %
Mycobacterium tuberculosis Possible hydrolase Monoglyceride lipase   303 aa 263 aa 23.2 %
Plasmodium berghei prodrug activation and resistance esterase, putative Monoglyceride lipase   303 aa 266 aa 22.9 %
Plasmodium vivax PST-A protein Monoglyceride lipase   303 aa 257 aa 21.0 %
Babesia bovis lysophospholipase, putative Monoglyceride lipase   303 aa 289 aa 22.8 %
Echinococcus granulosus fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.7 %
Candida albicans similar to S. cerevisiae YOR084W Monoglyceride lipase   303 aa 303 aa 23.4 %
Plasmodium knowlesi conserved Plasmodium protein, unknown function Monoglyceride lipase   303 aa 272 aa 20.2 %
Plasmodium knowlesi alpha/beta hydrolase, putative Monoglyceride lipase   303 aa 261 aa 21.5 %
Plasmodium knowlesi lysophospholipase, putative Monoglyceride lipase   303 aa 250 aa 22.4 %
Plasmodium berghei alpha/beta hydrolase, putative Monoglyceride lipase   303 aa 284 aa 20.4 %
Onchocerca volvulus Anandamide amidohydrolase   579 aa 539 aa 34.7 %
Mycobacterium ulcerans hydrolase Monoglyceride lipase   303 aa 284 aa 22.5 %
Plasmodium vivax unspecified product Monoglyceride lipase   303 aa 274 aa 23.4 %
Plasmodium knowlesi lysophospholipase, putative Monoglyceride lipase   303 aa 280 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.0301 0.6373
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0163 0.0301 0.0697
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0027 0.5
Mycobacterium ulcerans lysophospholipase 0.0084 0.0027 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0116 0.0138 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0163 0.0301 0.0794
Loa Loa (eye worm) phosphatidylinositol 3 0.0206 0.0449 0.1187
Echinococcus granulosus glycine receptor subunit alpha 1 0.0163 0.0301 0.0262
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0163 0.0301 0.0794
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0206 0.0449 0.0412
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0163 0.0301 0.0262
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Echinococcus granulosus glycine receptor subunit alpha 1 0.0163 0.0301 0.0262
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0163 0.0301 0.0262
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0163 0.0301 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Entamoeba histolytica hypothetical protein 0.0116 0.0138 0.2623
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0163 0.0301 0.0262
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0116 0.0138 0.2623
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0138 0.0262
Schistosoma mansoni nAChR subunit 0.0163 0.0301 0.6373
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Giardia lamblia GTOR 0.0206 0.0449 0.5
Plasmodium vivax PST-A protein 0.0084 0.0027 0.5
Brugia malayi Cation transporter family protein 0.0163 0.0301 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0163 0.0301 0.0262
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.009 0.0046 0.0007
Trypanosoma cruzi target of rapamycin kinase 3 0.0206 0.0449 0.1352
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0116 0.0138 0.2623
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0163 0.0301 0.0262
Loa Loa (eye worm) hypothetical protein 0.1092 0.3526 0.931
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0206 0.0449 1
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0184 0.4087
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0206 0.0449 0.0412
Schistosoma mansoni nAChR subunit 0.0163 0.0301 0.6373
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.0301 0.6373
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0206 0.0449 0.1352
Loa Loa (eye worm) hypothetical protein 0.0116 0.0138 0.0363
Onchocerca volvulus 0.0163 0.0301 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2957 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0163 0.0301 0.0697
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0163 0.0301 0.0262
Mycobacterium ulcerans hypothetical protein 0.0084 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 0.0184 0.0485
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0163 0.0301 0.0697
Onchocerca volvulus 0.0163 0.0301 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0163 0.0301 0.0697
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0206 0.0449 0.0412
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0027 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0206 0.0449 0.1352
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0206 0.0449 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0206 0.0449 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0206 0.0449 0.0412
Loa Loa (eye worm) hypothetical protein 0.0768 0.2401 0.6339
Onchocerca volvulus 0.0163 0.0301 1
Echinococcus granulosus glycine receptor subunit beta 0.0163 0.0301 0.0262
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0206 0.0449 0.1352
Loa Loa (eye worm) hypothetical protein 0.1167 0.3787 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0163 0.0301 0.0697
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.0594
Echinococcus multilocularis glycine receptor subunit beta 0.0163 0.0301 0.0262
Echinococcus granulosus glycine receptor subunit alpha 1 0.0163 0.0301 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.0594
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0206 0.0449 0.1094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0163 0.0301 0.0697
Mycobacterium tuberculosis Possible lysophospholipase 0.0084 0.0027 0.5
Schistosoma mansoni amidase 0.0123 0.0162 0.2981
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.0301 0.6373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Echinococcus multilocularis glycine receptor subunit beta 0.0163 0.0301 0.0262
Loa Loa (eye worm) ACC-1 protein 0.0163 0.0301 0.0794
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) LGC-31 protein 0.0163 0.0301 0.0794
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0163 0.0301 0.0697
Brugia malayi amidase 0.0123 0.0162 0.0326
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0163 0.0301 0.6373
Leishmania major hypothetical protein, conserved 0.1074 0.3462 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0138 0.0262
Onchocerca volvulus 0.0163 0.0301 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0129 0.0184 0.1478
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Schistosoma mansoni nAChR subunit 0.0163 0.0301 0.6373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Echinococcus granulosus nAChR subunit 0.0163 0.0301 0.0262
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0163 0.0301 0.0794
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0206 0.0449 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0163 0.0301 0.0262
Schistosoma mansoni hypothetical protein 0.009 0.0046 0.0163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0206 0.0449 0.1094
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0116 0.0138 0.0414
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0163 0.0301 0.0262
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0163 0.0301 0.0697
Trypanosoma cruzi hypothetical protein, conserved 0.1034 0.3325 1
Brugia malayi Cation transporter family protein 0.0163 0.0301 0.0697
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0206 0.0449 0.123
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0163 0.0301 0.0697
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0162 0.0123
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0163 0.0301 0.0697
Leishmania major phosphatidylinositol 3-kinase, putative 0.0206 0.0449 0.123
Schistosoma mansoni nAChR subunit 0.0163 0.0301 0.6373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0163 0.0301 0.0262
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0163 0.0301 0.0262
Brugia malayi FAT domain containing protein 0.009 0.0046 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0206 0.0449 0.123
Echinococcus granulosus serine protein kinase ATM 0.0116 0.0138 0.0099
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0206 0.0449 0.1352
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0163 0.0301 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.0594
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0116 0.0138 0.2395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0162 0.0123
Schistosoma mansoni nAChR subunit 0.0163 0.0301 0.6373
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0027 0.0594
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.0594
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0163 0.0301 0.0697
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.009 0.0046 0.0007
Trypanosoma cruzi monoglyceride lipase, putative 0.0084 0.0027 0.008
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Onchocerca volvulus 0.0163 0.0301 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0163 0.0301 0.0794
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0163 0.0301 0.0697
Echinococcus granulosus glycine receptor subunit beta 0.0163 0.0301 0.0262
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0084 0.0027 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.0162 0.2981
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0163 0.0301 0.0697
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0162 0.0123
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0206 0.0449 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0163 0.0301 0.0262
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0163 0.0301 0.0262
Echinococcus multilocularis serine protein kinase ATM 0.0116 0.0138 0.0099
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0206 0.0449 0.123
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0163 0.0301 0.6373
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.1167 0.3787 1
Schistosoma mansoni nAChR subunit 0.0163 0.0301 0.6373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0184 0.4087
Brugia malayi Cation transporter family protein 0.0163 0.0301 0.0697
Onchocerca volvulus 0.0163 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Loa Loa (eye worm) ACC-1 protein 0.0163 0.0301 0.0794
Entamoeba histolytica protein kinase rad3, putative 0.0116 0.0138 0.2623
Onchocerca volvulus Putative nachr subunit 0.0163 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0046 0.0122
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0206 0.0449 0.1187
Echinococcus multilocularis nAChR subunit 0.0163 0.0301 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0027 0.0594
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0116 0.0138 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0162 0.0427
Loa Loa (eye worm) GABA receptor subunit 0.0088 0.0039 0.0104
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0206 0.0449 0.123
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0162 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0163 0.0301 0.0697
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0129 0.0184 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0163 0.0301 0.0697
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0163 0.0301 0.6373
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0163 0.0301 0.0262
Schistosoma mansoni fkbp-rapamycin associated protein 0.0116 0.0138 0.2395
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0046 0.1025
Loa Loa (eye worm) hypothetical protein 0.0088 0.0039 0.0104
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0206 0.0449 1
Entamoeba histolytica hypothetical protein 0.0088 0.0039 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0163 0.0301 0.0262
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0027 0.5
Plasmodium falciparum esterase, putative 0.0084 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0163 0.0301 0.0794
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0116 0.0138 0.0099
Brugia malayi excitatory GABA receptor EXP-1A 0.0163 0.0301 0.0697
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0163 0.0301 0.0262
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0027 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Loa Loa (eye worm) hypothetical protein 0.0163 0.0301 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0449 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0138 0.3062
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0163 0.0301 0.0262
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0084 0.0027 0.5
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0163 0.0301 0.0262
Schistosoma mansoni nAChR subunit 0.0163 0.0301 0.6373

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 65 % Inhibition of FAAH assessed as membrane-bound anandamide hydrolysis at 10 uM ChEMBL. 17764163
Activity (binding) = 65 % Inhibition of FAAH assessed as membrane-bound anandamide hydrolysis at 10 uM ChEMBL. 17764163
Activity (binding) = 66 % Inhibition of FAAH assessed as membrane-bound anandamide hydrolysis at 10 uM after 60 mins ChEMBL. 17764163
Activity (binding) = 66 % Inhibition of FAAH assessed as membrane-bound anandamide hydrolysis at 10 uM after 60 mins ChEMBL. 17764163
Activity (binding) = 67 % Inhibition of FAAH assessed as membrane-bound anandamide hydrolysis at 10 uM after 120 mins ChEMBL. 17764163
Activity (binding) = 67 % Inhibition of FAAH assessed as membrane-bound anandamide hydrolysis at 10 uM after 120 mins ChEMBL. 17764163
IC50 (binding) = 4.5 uM Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
IC50 (binding) = 4.5 uM Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
IC50 (binding) = 4.5 uM Inhibition of rat brain membrane FAAH assessed as [3H]-anandamide hydrolysis after 10 mins by liquid scintillation spectroscopy ChEMBL. 22185522
IC50 (binding) = 12 uM Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis ChEMBL. 17764163
IC50 (binding) = 12 uM Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis ChEMBL. 17764163
IC50 (binding) = 19 uM Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
IC50 (binding) = 19 uM Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
Log I50 (binding) = 4.72 Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
Log I50 (binding) = 5.35 Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
Log I50 (binding) = 4.72 Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
Log I50 (binding) = 4.91 Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis ChEMBL. 17764163
Log I50 (binding) = 5.35 Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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