Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0094 | 0.0037 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0274 | 0.0575 | 0.3483 |
Loa Loa (eye worm) | dual specificity phosphatase | 0.0158 | 0.023 | 0.3993 |
Leishmania major | pteridine reductase 1 | 0.0094 | 0.0037 | 1 |
Loa Loa (eye worm) | twinkle helicase | 0.0181 | 0.0299 | 0.5193 |
Trichomonas vaginalis | hypothetical protein | 0.12 | 0.3338 | 0.5 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0274 | 0.0575 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.12 | 0.3338 | 1 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0274 | 0.0575 | 0.0575 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0635 | 0.1652 | 0.4948 |
Giardia lamblia | Dual specificity phosphatase, catalytic | 0.0158 | 0.023 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0274 | 0.0575 | 0.3483 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0635 | 0.1652 | 0.4948 |
Chlamydia trachomatis | replicative DNA helicase | 0.0635 | 0.1652 | 0.4948 |
Echinococcus granulosus | dual specificity protein phosphatase | 0.0158 | 0.023 | 0.023 |
Brugia malayi | Dual specificity phosphatase, catalytic domain containing protein | 0.0158 | 0.023 | 0.3993 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.12 | 0.3338 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.12 | 0.3338 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.12 | 0.3338 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.12 | 0.3338 | 1 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0635 | 0.1652 | 0.4948 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.12 | 0.3338 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.0635 | 0.1652 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0094 | 0.0037 | 1 |
Echinococcus multilocularis | dual specificity protein phosphatase | 0.0158 | 0.023 | 0.023 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0635 | 0.1652 | 0.4948 |
Onchocerca volvulus | 0.0094 | 0.0037 | 0.1607 | |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.12 | 0.3338 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0094 | 0.0037 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.0575 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0094 | 0.0037 | 0.0111 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0094 | 0.0037 | 0.0111 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0081 | 0 | 0.5 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0635 | 0.1652 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0274 | 0.0575 | 0.3483 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.3431 | 1 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0094 | 0.0037 | 1 |
Onchocerca volvulus | 0.0158 | 0.023 | 1 | |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0094 | 0.0037 | 0.0111 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0274 | 0.0575 | 0.3483 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0094 | 0.0037 | 0.0111 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0274 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0274 | 0.0575 | 1 |
Schistosoma mansoni | dual specificity protein phosphatase | 0.0158 | 0.023 | 0.139 |
Schistosoma mansoni | apoptosis regulator bax | 0.0274 | 0.0575 | 0.3483 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.12 | 0.3338 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0094 | 0.0037 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.95 uM | Inhibition of human factor 10a | ChEMBL. | 17416533 |
IC50 (binding) | = 0.95 uM | Inhibition of human factor 10a | ChEMBL. | 17416533 |
Selectivity ratio (binding) | > 100 | Selectivity for human factor 10a over human trypsin | ChEMBL. | 17416533 |
Selectivity ratio (binding) | > 7000 | Selectivity for human factor 10a over human thrombin | ChEMBL. | 17416533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.