Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | Curated by TDR Targets | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.4441 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.4441 | 0.1511 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.9187 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.4441 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0358 | 0.9187 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 1 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.012 | 0.1593 | 0.3587 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0358 | 0.9187 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0358 | 0.9187 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0084 | 0.0437 | 0.0984 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0358 | 0.9187 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.4441 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 1 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.4441 | 0.4834 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.4441 | 1 |
Schistosoma mansoni | lipoxygenase | 0.012 | 0.1593 | 0.3587 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.012 | 0.1593 | 0.3587 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.5 nM | Inhibition of human DPP4 | ChEMBL. | 17292611 |
IC50 (binding) | = 3.5 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
IC50 (binding) | = 3.5 nM | Inhibition of human DPP4 | ChEMBL. | 17292611 |
IC50 (binding) | = 3.5 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
Inhibition (functional) | = 38 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17292611 |
Inhibition (binding) | = 38 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 38 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.