Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | Curated by TDR Targets | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.2082 | 1 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0158 | 0.141 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.2082 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.2082 | 0.5247 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.0925 | 0.0441 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.0269 | 0.0072 |
Brugia malayi | RNA binding protein | 0.0065 | 0.0198 | 0.0717 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.2082 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.0925 | 0.0441 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.0198 | 0.0717 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.007 | 0.0269 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.034 | 0.3788 | 0.3663 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.435 | 0.5 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0158 | 0.141 | 0.1237 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.007 | 0.0269 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.0198 | 0.0717 |
Echinococcus multilocularis | geminin | 0.0171 | 0.1576 | 0.1406 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.0269 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 0.435 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 0.435 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.007 | 0.0269 | 0.1291 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.0198 | 0.0949 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.0198 | 0.0949 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 0.435 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.0269 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0383 | 0.435 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 0.435 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.435 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.034 | 0.3788 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.0198 | 0.0949 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0158 | 0.141 | 0.6774 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0158 | 0.141 | 0.6774 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0158 | 0.141 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.0925 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.2082 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.0269 | 0.0198 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0198 | 0.0949 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0158 | 0.141 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0198 | 0.0949 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0198 | 0.0949 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0158 | 0.141 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.1576 | 0.3839 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.141 | 0.6774 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.0925 | 0.0441 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0198 | 0.0949 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1576 | 0.7571 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0158 | 0.141 | 0.6691 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0052 | 0.0251 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1576 | 0.7571 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.0269 | 0.1067 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0198 | 0.0949 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0158 | 0.141 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.007 | 0.0269 | 0.5 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0158 | 0.141 | 0.3377 |
Toxoplasma gondii | hypothetical protein | 0.0117 | 0.0876 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.2082 | 0.1922 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 0.435 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.3 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
IC50 (binding) | = 4.3 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
Inhibition (binding) | = 44 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rats plasma at 1 mg/kg, po after 10 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 44 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rats plasma at 1 mg/kg, po after 10 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 73 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 73 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.