Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0679 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.4134 | 0.8357 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0679 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4813 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0679 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0679 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0679 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4134 | 0.8357 | 0.8357 |
Echinococcus granulosus | hypothetical protein | 0.0842 | 0.0394 | 1 |
Onchocerca volvulus | 0.4813 | 1 | 1 | |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0679 | 0 | 0.5 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0679 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.4813 | 1 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0679 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.4134 | 0.8357 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.4813 | 1 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.4134 | 0.8357 | 1 |
Onchocerca volvulus | 0.4813 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0679 | 0 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.0373 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4134 | 0.8357 | 0.8357 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0679 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.4134 | 0.8357 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0679 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0679 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human 5HT2C receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | Agonist activity at human 5HT2B receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | Agonist activity at human 5HT2A receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | 0 | Agonist activity at human 5HT2A receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Activity (functional) | 0 | Agonist activity at human 5HT2B receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Activity (functional) | 0 | Agonist activity at human 5HT2C receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Log Ki (binding) | Displacement of [3H]5HT from human 5HT2B receptor expressed in HEK293 cells | ChEMBL. | 17079142 | |
Log Ki (binding) | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in HEK293 cells | ChEMBL. | 17079142 | |
Log Ki (binding) | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells | ChEMBL. | 17079142 | |
Log Ki (binding) | 0 | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Log Ki (binding) | 0 | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Log Ki (binding) | 0 | Displacement of [3H]5HT from human 5HT2B receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.