Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, N type, alpha 1B subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.1498 | 0.1498 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0146 | 0.2172 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.006 | 0.0236 | 0.5 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.0479 | 0.0295 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.1498 | 0.1498 |
Leishmania major | hypothetical protein, conserved | 0.0427 | 0.8472 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0495 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0116 | 0.1498 | 0.1498 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.006 | 0.0236 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.1498 | 0.1498 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0116 | 0.1498 | 0.1293 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.006 | 0.0236 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.1498 | 0.1498 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.006 | 0.0236 | 0.0236 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0427 | 0.8472 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0495 | 1 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.006 | 0.0236 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.1498 | 0.1498 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0427 | 0.8472 | 0.8472 |
Trypanosoma brucei | lipase domain protein, putative | 0.0427 | 0.8472 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0427 | 0.8472 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0146 | 0.2172 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0116 | 0.1498 | 0.1498 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0495 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0427 | 0.8472 | 0.8472 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0116 | 0.1498 | 0.1498 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.006 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 1 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.0479 | 0.0295 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0495 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0427 | 0.8472 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0495 | 1 | 1 |
Schistosoma mansoni | amidase | 0.0495 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.006 | 0.0236 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0116 | 0.1498 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1498 | 0.1293 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.1498 | 0.1498 |
Brugia malayi | Lipase family protein | 0.0427 | 0.8472 | 0.8435 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.006 | 0.0236 | 0.0236 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0116 | 0.1498 | 0.1293 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0427 | 0.8472 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0116 | 0.1498 | 0.1293 |
Onchocerca volvulus | 0.0427 | 0.8472 | 0.5 | |
Loa Loa (eye worm) | calcium channel | 0.0116 | 0.1498 | 0.1293 |
Loa Loa (eye worm) | lipase | 0.0427 | 0.8472 | 0.8435 |
Schistosoma mansoni | voltage-gated cation channel | 0.0116 | 0.1498 | 0.1293 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.006 | 0.0236 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.006 | 0.0236 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0427 | 0.8472 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.006 | 0.0236 | 0.0236 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.53 uM | Inhibition of calcium channel Cav2.2 in IMR32 cells | ChEMBL. | 17134896 |
IC50 (binding) | = 0.53 uM | Inhibition of calcium channel Cav2.2 in IMR32 cells | ChEMBL. | 17134896 |
IC50 (binding) | = 4.16 uM | Inhibition of calcium channel L type in IMR32 cells | ChEMBL. | 17134896 |
Ratio IC50 (binding) | = 7.8 | Selectivity for calcium channel Cav2.2 over calcium channel L type | ChEMBL. | 17134896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.