Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | prolyl endopeptidase | 0.1027 | 0.0721 | 0.1908 |
Plasmodium falciparum | peptidase, putative | 0.1027 | 0.0721 | 1 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.1027 | 0.0721 | 0.1571 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.1027 | 0.0721 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.1027 | 0.0721 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.5237 | 0.4588 | 0.4588 |
Brugia malayi | prolyl oligopeptidase family protein | 0.5237 | 0.4588 | 0.4588 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0373 | 0.012 | 0.012 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.1027 | 0.0721 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.1027 | 0.0721 | 0.1571 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0373 | 0.012 | 0.012 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.1027 | 0.0721 | 0.0721 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.1027 | 0.0721 | 0.0721 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.1027 | 0.0721 | 0.0721 |
Wolbachia endosymbiont of Brugia malayi | Xaa-Pro aminopeptidase | 0.0571 | 0.0302 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.1027 | 0.0721 | 0.0721 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.1027 | 0.0721 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.1027 | 0.0721 | 0.1571 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1027 | 0.0721 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 1.113 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1027 | 0.0721 | 0.1908 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.5237 | 0.4588 | 0.4588 |
Trypanosoma cruzi | oligopeptidase b | 0.1027 | 0.0721 | 0.1571 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1027 | 0.0721 | 0.0721 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.1027 | 0.0721 | 0.1571 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1027 | 0.0721 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.1027 | 0.0721 | 0.0721 |
Toxoplasma gondii | creatinase domain-containing protein | 0.0571 | 0.0302 | 0.0799 |
Trypanosoma brucei | prolyl endopeptidase | 0.1027 | 0.0721 | 0.1571 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0571 | 0.0302 | 0.0302 |
Mycobacterium tuberculosis | Probable peptidase | 0.1027 | 0.0721 | 1 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.1027 | 0.0721 | 0.0721 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0373 | 0.012 | 0.012 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1027 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.1027 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.0159 | 0.0159 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0287 | 0.0041 | 0.0041 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.5237 | 0.4588 | 0.4588 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.5237 | 0.4588 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.1027 | 0.0721 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1027 | 0.0721 | 0.0721 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0571 | 0.0302 | 0.0302 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0571 | 0.0302 | 0.4187 |
Brugia malayi | hypothetical protein | 0.3328 | 0.2835 | 0.2835 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.1027 | 0.0721 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.1027 | 0.0721 | 0.1571 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.4355 | 0.3777 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.5237 | 0.4588 | 1 |
Trypanosoma cruzi | aminopeptidase P1, putative | 0.0571 | 0.0302 | 0.0658 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.5237 | 0.4588 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.1027 | 0.0721 | 0.1571 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 1.113 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 1.113 | 1 | 1 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.1027 | 0.0721 | 0.1908 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 1.113 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.1027 | 0.0721 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.1027 | 0.0721 | 0.0721 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0571 | 0.0302 | 0.0658 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.1027 | 0.0721 | 0.1571 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0571 | 0.0302 | 0.0302 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1027 | 0.0721 | 0.0721 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.1027 | 0.0721 | 1 |
Chlamydia trachomatis | aminopeptidase P | 0.0314 | 0.0066 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.1027 | 0.0721 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.1027 | 0.0721 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1027 | 0.0721 | 0.1571 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 1.113 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.1027 | 0.0721 | 1 |
Onchocerca volvulus | 0.0314 | 0.0066 | 0.0066 | |
Loa Loa (eye worm) | hypothetical protein | 0.1909 | 0.1531 | 0.1531 |
Trypanosoma brucei | Xaa-Pro aminopeptidase, putative | 0.0571 | 0.0302 | 0.0658 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.1027 | 0.0721 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.5237 | 0.4588 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1027 | 0.0721 | 0.1571 |
Treponema pallidum | aminopeptidase P | 0.0571 | 0.0302 | 0.5 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0571 | 0.0302 | 0.0658 |
Echinococcus granulosus | prolyl endopeptidase | 0.1027 | 0.0721 | 0.0721 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.1027 | 0.0721 | 1 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.1027 | 0.0721 | 0.1571 |
Entamoeba histolytica | aminopeptidase, putative | 0.0571 | 0.0302 | 0.4188 |
Trypanosoma cruzi | prolyl endopeptidase | 0.1027 | 0.0721 | 0.1571 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.1027 | 0.0721 | 1 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0415 | 0.0159 | 0.0347 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.1027 | 0.0721 | 0.1571 |
Leishmania major | oligopeptidase b | 0.1027 | 0.0721 | 0.1571 |
Loa Loa (eye worm) | hypothetical protein | 0.3328 | 0.2835 | 0.2835 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.1027 | 0.0721 | 0.0721 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.5237 | 0.4588 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 200 uM | Inhibition of acetosyringone-induced virB::lacZ expression in Agrobacterium tumefaciens A348/pSW209 | ChEMBL. | 17470391 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.