Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.5033 | 0.5033 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0138 | 0.0138 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0444 | 1 | 1 |
Onchocerca volvulus | 0.0089 | 0.1578 | 0.1578 | |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0444 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0444 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0444 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0209 | 0.4437 | 0.4437 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0444 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0209 | 0.4437 | 0.4359 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0209 | 0.4437 | 0.432 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0209 | 0.4437 | 0.432 |
Schistosoma mansoni | zinc finger protein | 0.0209 | 0.4437 | 0.4359 |
Onchocerca volvulus | 0.0209 | 0.4437 | 0.4437 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0444 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0234 | 0.5033 | 0.4963 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0234 | 0.5033 | 0.5033 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.005 | 0.066 | 0.0463 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0035 | 0.0305 | 0.0699 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.005 | 0.066 | 0.0463 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0035 | 0.0305 | 0.0699 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0444 | 1 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0034 | 0.0278 | 0.0074 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0444 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.005 | 0.066 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0035 | 0.0305 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.012 | 0.2311 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0444 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0209 | 0.4437 | 0.4359 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0041 | 0.0447 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0444 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0209 | 0.4437 | 0.4437 |
Brugia malayi | nuclear receptor RXR | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.5033 | 0.5033 |
Brugia malayi | Raf kinase | 0.0031 | 0.0206 | 0.0206 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0209 | 0.4437 | 0.4437 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.005 | 0.066 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0444 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0444 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0444 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0116 | 0.2231 | 0.2068 |
Schistosoma mansoni | thyroid hormone receptor | 0.0444 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0031 | 0.0206 | 0.0069 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0032 | 0.0235 | 0.8457 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0209 | 0.4437 | 0.432 |
Brugia malayi | hypothetical protein | 0.0234 | 0.5033 | 0.5033 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.5033 | 0.5033 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0444 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0444 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0444 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0154 | 0.3115 | 0.297 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0034 | 0.0278 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.005 | 0.066 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0444 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0032 | 0.0235 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0154 | 0.3115 | 0.3115 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.005 | 0.066 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0034 | 0.0278 | 0.0278 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0032 | 0.0235 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0209 | 0.4437 | 0.432 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0444 | 1 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0034 | 0.0278 | 0.0143 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0209 | 0.4437 | 0.4359 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.012 | 0.2311 | 0.2311 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0209 | 0.4437 | 0.432 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Trypanosoma brucei | glucosidase, putative | 0.0034 | 0.0278 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0444 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0209 | 0.4437 | 0.4437 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0209 | 0.4437 | 0.4359 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0444 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0444 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0444 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0209 | 0.4437 | 0.4437 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0209 | 0.4437 | 0.4437 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0035 | 0.0305 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0278 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.463 | 0.463 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.9327 | 0.9327 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0035 | 0.0305 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | raf kinase | 0.0031 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0154 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0041 | 0.0447 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0209 | 0.4437 | 0.4437 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.9327 | 0.9327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0444 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0209 | 0.4437 | 0.432 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0209 | 0.4437 | 0.432 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0209 | 0.4437 | 0.4437 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0444 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0444 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.005 | 0.066 | 0.053 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0209 | 0.4437 | 0.4437 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0444 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0132 | 0.2607 | 0.2504 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0209 | 0.4437 | 0.432 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0022 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0444 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.012 | 0.2311 | 0.2149 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0209 | 0.4437 | 0.432 |
Brugia malayi | nuclear receptor RXR | 0.0234 | 0.5033 | 0.5033 |
Schistosoma mansoni | thyroid hormone receptor | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0034 | 0.0278 | 0.0278 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0234 | 0.5033 | 0.5033 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0444 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0444 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0444 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0444 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0444 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0444 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0154 | 0.3115 | 0.297 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0444 | 1 | 1 |
Onchocerca volvulus | 0.0217 | 0.463 | 0.463 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.005 | 0.066 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0444 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0444 | 1 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0034 | 0.0278 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Onchocerca volvulus | 0.0209 | 0.4437 | 0.4437 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0209 | 0.4437 | 0.4359 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0444 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0444 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0209 | 0.4437 | 0.432 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0278 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0234 | 0.5033 | 0.4928 |
Brugia malayi | steroid hormone receptor | 0.0444 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.005 | 0.066 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0209 | 0.4437 | 0.4437 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0209 | 0.4437 | 0.432 |
Brugia malayi | tailless protein | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.5033 | 0.5033 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0209 | 0.4437 | 0.4437 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0035 | 0.0305 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Onchocerca volvulus | 0.0444 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0447 | 0.0447 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0234 | 0.5033 | 0.5033 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.005 | 0.066 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Brugia malayi | ecdysone receptor | 0.0209 | 0.4437 | 0.4437 |
Echinococcus granulosus | FTZ F1 alpha | 0.0444 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0209 | 0.4437 | 0.4359 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0444 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0209 | 0.4437 | 0.432 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.5033 | 0.5033 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0444 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0028 | 0.0138 | 0.0138 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0041 | 0.0447 | 0.0447 |
Brugia malayi | nuclear hormone receptor | 0.0444 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0154 | 0.3115 | 0.297 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0234 | 0.5033 | 0.4963 |
Brugia malayi | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Brugia malayi | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0444 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0234 | 0.5033 | 0.5033 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0234 | 0.5033 | 0.4928 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4437 | 0.4437 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0444 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0444 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0444 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0217 | 0.463 | 0.463 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0444 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0209 | 0.4437 | 0.4437 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0444 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0132 | 0.2607 | 0.2504 |
Schistosoma mansoni | nuclear hormone receptor | 0.0209 | 0.4437 | 0.4359 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.012 | 0.2311 | 0.2311 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0034 | 0.0278 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0209 | 0.4437 | 0.4437 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0034 | 0.0278 | 0.422 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.12 uM | Inhibition of CDK1/cyclinB | ChEMBL. | 17303421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.