Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2716 | 0.3981 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0172 | 0.2716 | 0.3981 |
Onchocerca volvulus | 0.0172 | 0.2716 | 0.3981 | |
Leishmania major | endonuclease G, putative | 0.0103 | 0.1301 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0145 | 0.2158 | 0.2158 |
Trypanosoma cruzi | endonuclease G, putative | 0.0103 | 0.1301 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0172 | 0.2716 | 0.3981 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0145 | 0.2158 | 0.2158 |
Trypanosoma brucei | endonuclease G, putative | 0.0103 | 0.1301 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Echinococcus granulosus | ectonucleotide | 0.0145 | 0.2158 | 0.2158 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2716 | 0.3981 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Onchocerca volvulus | 0.0371 | 0.6821 | 1 | |
Trichomonas vaginalis | esterase, putative | 0.004 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Echinococcus multilocularis | ectonucleotide | 0.0145 | 0.2158 | 0.2158 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0103 | 0.1301 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0172 | 0.2716 | 0.3981 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2716 | 0.3981 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Onchocerca volvulus | 0.0172 | 0.2716 | 0.3981 | |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0371 | 0.6821 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0 | 0.5 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0371 | 0.6821 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0256 | 0.4458 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0525 | 1 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0103 | 0.1301 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0103 | 0.1301 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0172 | 0.2716 | 0.3981 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0525 | 1 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0103 | 0.1301 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0103 | 0.1301 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2158 | 0.3164 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0525 | 1 | 1 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0103 | 0.1301 | 0.1908 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0 | 0.5 |
Schistosoma mansoni | endonuclease related | 0.0103 | 0.1301 | 0.1908 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0103 | 0.1301 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0172 | 0.2716 | 0.2716 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0172 | 0.2716 | 0.3981 |
Echinococcus granulosus | Endonuclease G | 0.0103 | 0.1301 | 0.1301 |
Trypanosoma brucei | endonuclease G, putative | 0.0103 | 0.1301 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.0103 | 0.1301 | 0.1301 |
Schistosoma mansoni | hypothetical protein | 0.0371 | 0.6821 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1 nM | Agonist activity at human AR | ChEMBL. | 17267219 |
EC50 (functional) | = 1 nM | Agonist activity at human AR | ChEMBL. | 17267219 |
Efficacy (functional) | < 20 % | Antagonist activity at human AR assessed as inhibition of DHT-induced response | ChEMBL. | 17267219 |
Efficacy (functional) | < 20 % | Antagonist activity at human AR assessed as inhibition of DHT-induced response | ChEMBL. | 17267219 |
Efficacy (functional) | = 125 % | Agonist activity at human AR relative to DHT | ChEMBL. | 17267219 |
Efficacy (functional) | = 125 % | Agonist activity at human AR relative to DHT | ChEMBL. | 17267219 |
IC50 (functional) | > 10000 nM | Antagonist activity at human AR | ChEMBL. | 17267219 |
IC50 (functional) | > 10000 nM | Antagonist activity at human AR | ChEMBL. | 17267219 |
Ki (binding) | = 0.5 nM | Binding affinity to human AR | ChEMBL. | 17267219 |
Ki (binding) | = 0.5 nM | Binding affinity to human AR | ChEMBL. | 17267219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.