Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0108 | 0.1091 | 0.1091 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0245 | 0.9095 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0261 | 1 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0223 | 0.7774 | 0.7774 |
Trypanosoma cruzi | GMP reductase | 0.0261 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.0261 | 1 | 1 |
Brugia malayi | MBOAT family protein | 0.0244 | 0.9002 | 0.9002 |
Schistosoma mansoni | zinc finger protein | 0.0244 | 0.9002 | 0.9002 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0261 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0108 | 0.1091 | 0.1091 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0261 | 1 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0108 | 0.1091 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0261 | 1 | 1 |
Loa Loa (eye worm) | GMP reductase | 0.0108 | 0.1091 | 0.1091 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0261 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0261 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0261 | 1 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0261 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0137 | 0.276 | 0.0954 |
Leishmania major | guanosine monophosphate reductase | 0.0261 | 1 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0261 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0261 | 1 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0261 | 1 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0245 | 0.9095 | 0.8869 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.0244 | 0.9002 | 0.9002 |
Trypanosoma cruzi | GMP reductase | 0.0261 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0261 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0244 | 0.9002 | 0.9002 |
Echinococcus multilocularis | zinc finger protein | 0.0223 | 0.7774 | 0.7774 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0245 | 0.9095 | 0.5 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0261 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.009 | 0 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0244 | 0.9002 | 0.9002 |
Brugia malayi | GMP reductase | 0.0108 | 0.1091 | 0.1091 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0261 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.009 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.18 uM | Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISA | ChEMBL. | 17880056 |
IC50 (functional) | = 0.18 uM | Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISA | ChEMBL. | 17880056 |
IC50 (functional) | = 0.206 uM | Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assay | ChEMBL. | 17880056 |
IC50 (functional) | = 0.206 uM | Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assay | ChEMBL. | 17880056 |
permeability (ADMET) | = 0 cm/s | Permeability across Caco cell membrane | ChEMBL. | 17880056 |
Solubility | = 29 ug ml-1 | Aqueous solubility of the compound | ChEMBL. | 17880056 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.