TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.851 | Formula: C19H14ClN3O3S
H donors: 3 H acceptors: 3 LogP: 3.67 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc(O)c2c(c1)S(=O)(=O)N=C(N2)Nc1ccccc1c1ccccc1
InChi: 1S/C19H14ClN3O3S/c20-13-10-16(24)18-17(11-13)27(25,26)23-19(22-18)21-15-9-5-4-8-14(15)12-6-2-1-3-7-12/h1-11,24H,(H2,21,22,23)
InChiKey: ZMMHPWURJDODJF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-X-C motif) receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0249	0.2025	0.335
Echinococcus multilocularis	serine threonine protein kinase	0.0249	0.2025	0.4124
Brugia malayi	hypothetical protein	0.002	0.0065	0.0045
Echinococcus granulosus	serine:threonine protein kinase N2	0.0249	0.2025	0.4124
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0013	0	0.0001
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0249	0.2025	0.4124
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0238	0.1932	0.3196
Toxoplasma gondii	AGC kinase	0.0715	0.6027	1
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0582	0.4882	0.4874
Brugia malayi	Hr1 repeat family protein	0.0249	0.2025	0.2009
Schistosoma mansoni	serine/threonine protein kinase	0.0249	0.2025	0.4124
Echinococcus granulosus	twitchin	0.0026	0.0113	0.0191
Onchocerca volvulus		0.014	0.1088	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0221	0.1787	0.3634
Echinococcus granulosus	nervana 2	0.0467	0.3892	0.7964
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0479	0.4003	1
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Trypanosoma cruzi	Protein kinase B	0.0479	0.4003	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0249	0.2025	0.4124
Entamoeba histolytica	protein kinase 2, putative	0.0477	0.3985	0.6594
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Echinococcus multilocularis	tyrosine kinase	0.002	0.0065	0.0093
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0023	0.0089	0.0143
Schistosoma mansoni	tyrosine kinase	0.0023	0.0089	0.0143
Echinococcus granulosus	tyrosine protein kinase Srms	0.002	0.0065	0.0093
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0717	0.6044	1
Entamoeba histolytica	protein kinase, putative	0.0717	0.6044	1
Trichomonas vaginalis	AGC family protein kinase	0.0249	0.2025	0.335
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0023	0.0089	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0027	0.0125	0.0106
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0021	0.0002
Brugia malayi	Protein kinase domain containing protein	0.002	0.0065	0.0045
Echinococcus granulosus	protein kinase c iota type	0.0249	0.2025	0.4124
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0467	0.3892	0.7964
Onchocerca volvulus		0.002	0.0065	0.0526
Trichomonas vaginalis	AGC family protein kinase	0.0717	0.6044	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0023	0.0089	0.0222
Onchocerca volvulus		0.002	0.0065	0.0526
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0479	0.4003	0.6622
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Echinococcus multilocularis	tyrosine protein kinase Abl	0.01	0.0748	0.1497
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0023	0.0089	0.0143
Echinococcus multilocularis	tyrosine protein kinase shark	0.002	0.0065	0.0093
Schistosoma mansoni	hypothetical protein	0.014	0.1088	0.2197
Brugia malayi	Protein kinase domain containing protein	0.0249	0.2025	0.2009
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0249	0.2025	0.4124
Loa Loa (eye worm)	TK/ABL protein kinase	0.0221	0.1787	0.1771
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0023	0.0089	0.0143
Leishmania major	protein kinase, putative	0.0023	0.0089	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0479	0.4003	0.8191
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0249	0.2025	0.201
Trichomonas vaginalis	AGC family protein kinase	0.0582	0.4882	0.8077
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Schistosoma mansoni	atypical protein kinase C	0.0249	0.2025	0.4124
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0249	0.2025	0.201
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0249	0.2025	0.4124
Schistosoma mansoni	tyrosine kinase	0.002	0.0065	0.0093
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0013	0	0.0001
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0023	0.0089	0.0143
Echinococcus multilocularis	nervana 2	0.0467	0.3892	0.7964
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0477	0.3985	0.9957
Trichomonas vaginalis	AGC family protein kinase	0.0717	0.6044	1
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0015	0.002	0.0001
Echinococcus granulosus	tyrosine protein kinase Blk	0.002	0.0065	0.0093
Trichomonas vaginalis	AGC family protein kinase	0.0582	0.4882	0.8077
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.002	0.0065	0.0093
Trichomonas vaginalis	AGC family protein kinase	0.0582	0.4882	0.8077
Echinococcus multilocularis	tyrosine protein kinase Srms	0.002	0.0065	0.0093
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.002	0.0065	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0249	0.2025	0.201
Echinococcus granulosus	NDR protein kinase	0.0249	0.2025	0.4124
Schistosoma mansoni	serine/threonine protein kinase	0.0249	0.2025	0.4124
Schistosoma mansoni	serine/threonine kinase	0.0249	0.2025	0.4124
Brugia malayi	SH2 domain containing protein	0.002	0.0065	0.0045
Brugia malayi	protein kinase C II.	0.0249	0.2025	0.2009
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0023	0.0089	0.0143
Echinococcus granulosus	c src tyrosine kinase	0.0023	0.0089	0.0143
Loa Loa (eye worm)	SRC-1	0.0023	0.0089	0.007
Loa Loa (eye worm)	hypothetical protein	0.002	0.0065	0.0045
Entamoeba histolytica	hypothetical protein	0.0013	0	0.0001
Echinococcus granulosus	serine/threonine protein kinase	0.0479	0.4003	0.8191
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0019	0.0052	0.0085
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0023	0.0089	0.0143
Schistosoma mansoni	tyrosine kinase	0.002	0.0065	0.0093
Plasmodium falciparum	protein kinase, putative	0.0023	0.0089	0.0223
Entamoeba histolytica	protein kinase, putative	0.0715	0.6027	0.9972
Trichomonas vaginalis	AGC family protein kinase	0.0717	0.6044	1
Onchocerca volvulus		0.002	0.0065	0.0526
Entamoeba histolytica	protein kinase, putative	0.0717	0.6044	1
Echinococcus multilocularis	nervana 2	0.0467	0.3892	0.7964
Schistosoma mansoni	protein kinase	0.0023	0.0089	0.0143
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0473	0.0454
Entamoeba histolytica	protein kinase domain containing protein	0.0023	0.0089	0.0147
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0477	0.3985	1
Echinococcus granulosus	Protein kinase C brain isozyme	0.0249	0.2025	0.4124
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.002	0.0065	0.0093
Loa Loa (eye worm)	hypothetical protein	0.014	0.1088	0.1071
Entamoeba histolytica	protein kinase, putative	0.0013	0	0.0001
Echinococcus granulosus	Glutaredoxin protein 5	0.0467	0.3892	0.7964
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0023	0.0089	0.0143
Brugia malayi	Protein kinase domain containing protein	0.002	0.0065	0.0045
Echinococcus multilocularis	tyrosine protein kinase Blk	0.002	0.0065	0.0093
Echinococcus multilocularis	rac serine:threonine kinase	0.0479	0.4003	0.8191
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0023	0.0089	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Onchocerca volvulus		0.002	0.0065	0.0526
Loa Loa (eye worm)	hypothetical protein	0.1026	0.8693	0.8693
Entamoeba histolytica	hypothetical protein	0.0013	0	0.0001
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0582	0.4882	1
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Schistosoma mansoni	serine/threonine-protein kinase	0.0479	0.4003	0.8191
Echinococcus multilocularis	protein kinase c epsilon type	0.0249	0.2025	0.4124
Echinococcus multilocularis	c src tyrosine kinase	0.0023	0.0089	0.0143
Schistosoma mansoni	serine/threonine protein kinase	0.0249	0.2025	0.4124
Entamoeba histolytica	protein kinase, putative	0.0013	0	0.0001
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Schistosoma mansoni	tyrosine kinase	0.0023	0.0089	0.0143
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0477	0.3985	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0221	0.1787	0.3634
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0023	0.0089	0.0143
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0023	0.0089	0.0143
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0034	0.0182	0.0334
Trichomonas vaginalis	AGC family protein kinase	0.0251	0.2042	0.3378
Onchocerca volvulus		0.014	0.1088	1
Schistosoma mansoni	protein kinase	0.0023	0.0089	0.0143
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0249	0.2025	0.4124
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0023	0.0089	0.0143
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.002	0.0065	0.0093
Entamoeba histolytica	protein kinase, putative	0.0013	0	0.0001
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0013	0	0.0001
Entamoeba histolytica	protein kinase, putative	0.0019	0.0052	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Schistosoma mansoni	serine/threonine protein kinase	0.0249	0.2025	0.4124
Trichomonas vaginalis	AGC family protein kinase	0.0249	0.2025	0.335
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0477	0.3985	0.8156
Brugia malayi	Protein kinase domain containing protein	0.002	0.0065	0.0045
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0249	0.2025	0.4124
Brugia malayi	Protein kinase domain containing protein	0.0582	0.4882	0.4872
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0013	0	0.0001
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0715	0.6027	0.6021
Schistosoma mansoni	tyrosine kinase	0.0023	0.0089	0.0143
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Echinococcus granulosus	nervana 2	0.0467	0.3892	0.7964
Loa Loa (eye worm)	TK protein kinase	0.002	0.0065	0.0045
Brugia malayi	Protein kinase domain containing protein	0.0249	0.2025	0.2009
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0249	0.2025	0.4124
Schistosoma mansoni	hypothetical protein	0.014	0.1088	0.2197
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0582	0.4882	0.4874
Schistosoma mansoni	serine/threonine protein kinase	0.0582	0.4882	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0477	0.3985	0.8156
Brugia malayi	Tyrosine-protein kinase abl-1	0.01	0.0748	0.0729
Echinococcus multilocularis	protein kinase c iota type	0.0249	0.2025	0.4124
Echinococcus granulosus	activin receptor type	0.0023	0.0089	0.0143
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0582	0.4882	1
Brugia malayi	Protein kinase domain containing protein	0.002	0.0065	0.0045
Loa Loa (eye worm)	TK/ALK protein kinase	0.1178	0.9997	1
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0249	0.2025	0.4124
Schistosoma mansoni	protein kinase	0.0023	0.0089	0.0143
Trypanosoma brucei	protein kinase, putative	0.0023	0.0089	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Giardia lamblia	Kinase, AGC PKA	0.0477	0.3985	0.5
Echinococcus granulosus	protein kinase C gamma type	0.0249	0.2025	0.4124
Trichomonas vaginalis	AGC family protein kinase	0.0717	0.6044	1
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0068	0.0473	0.0933
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0717	0.6044	0.6038
Echinococcus multilocularis	Glutaredoxin protein 5	0.0467	0.3892	0.7964
Echinococcus granulosus	tyrosine kinase	0.002	0.0065	0.0093
Schistosoma mansoni	serine/threonine protein kinase	0.0249	0.2025	0.4124
Schistosoma mansoni	tyrosine kinase	0.0213	0.1718	0.3493
Echinococcus granulosus	MAM	0.014	0.1088	0.2197
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0249	0.2025	0.4124
Echinococcus multilocularis	activin receptor type	0.0023	0.0089	0.0143
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0068	0.0476	0.094
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0013	0	0.0001
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0013	0	0.0001
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0023	0.0089	0.0143
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0027	0.0125	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0654	0.0636
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0249	0.2025	0.201
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0023	0.0089	0.0143
Brugia malayi	SRC-1	0.0023	0.0089	0.007
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0023	0.0089	0.0143
Entamoeba histolytica	protein kinase, putative	0.0013	0	0.0001
Echinococcus granulosus	tyrosine kinase	0.002	0.0065	0.0093
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0023	0.0089	0.0143
Trichomonas vaginalis	AGC family protein kinase	0.0249	0.2025	0.335
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0023	0.0089	0.0222
Entamoeba histolytica	protein kinase, putative	0.0582	0.4882	0.8077
Brugia malayi	p70 ribosomal S6 kinase beta	0.0715	0.6027	0.6019
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0023	0.0089	0.0143
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0467	0.3892	0.7964
Brugia malayi	Protein kinase domain containing protein	0.0717	0.6044	0.6036
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0023	0.0089	0.0143
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0023	0.0089	0.0143
Echinococcus granulosus	tyrosine protein kinase shark	0.002	0.0065	0.0093
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0023	0.0089	0.0143
Schistosoma mansoni	serine/threonine protein kinase	0.0249	0.2025	0.4124
Schistosoma mansoni	tyrosine kinase	0.0023	0.0089	0.0143
Schistosoma mansoni	serine/threonine protein kinase	0.0249	0.2025	0.4124
Brugia malayi	hypothetical protein	0.014	0.1088	0.107
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0249	0.2025	0.201
Echinococcus multilocularis	MAM	0.014	0.1088	0.2197
Loa Loa (eye worm)	hypothetical protein	0.014	0.1088	0.1071
Entamoeba histolytica	protein kinase, putative	0.0013	0	0.0001
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0023	0.0089	0.0143
Onchocerca volvulus		0.002	0.0065	0.0526
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0023	0.0089	0.0143
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0249	0.2025	0.201
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0249	0.2025	0.4124
Echinococcus granulosus	serine threonine protein kinase nrc	0.0477	0.3985	0.8156
Brugia malayi	Tyrosine-protein kinase abl-1	0.0124	0.0954	0.0936
Brugia malayi	Protein kinase domain containing protein	0.002	0.0065	0.0045
Brugia malayi	SH2 domain containing protein	0.002	0.0065	0.0045
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0065	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0717	0.6044	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0023	0.0089	0.0143
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0068	0.0473	0.0455
Trichomonas vaginalis	AGC family protein kinase	0.0717	0.6044	1
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0582	0.4882	0.4872
Echinococcus granulosus	protein kinase c epsilon type	0.0249	0.2025	0.4124
Trichomonas vaginalis	AGC family protein kinase	0.0013	0	0.0001
Onchocerca volvulus		0.002	0.0065	0.0526
Entamoeba histolytica	p21-activated kinase	0.0013	0	0.0001
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0249	0.2025	0.201
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.002	0.0065	0.0093
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0479	0.4003	0.6622
Loa Loa (eye worm)	hypothetical protein	0.014	0.1088	0.1071
Brugia malayi	protein-tyrosine kinase	0.002	0.0065	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0717	0.6044	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.23 uM	Displacement of human recombinant [125I]IL8 from CXCR2 receptor expressed in CHO cells	ChEMBL.	17524641
IC50 (binding)	= 0.23 uM	Displacement of human recombinant [125I]IL8 from CXCR2 receptor expressed in CHO cells	ChEMBL.	17524641

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 442386