Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0157 | 0.1636 | 0.8971 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.0609 | 0.0609 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0157 | 0.1636 | 0.1636 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0157 | 0.1636 | 0.8971 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0306 | 0.3628 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.0609 | 0.3341 |
Onchocerca volvulus | 0.0091 | 0.075 | 0.5 | |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0171 | 0.1824 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0135 | 0.1343 | 0.7365 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0171 | 0.1824 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0306 | 0.3628 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0081 | 0.0609 | 0.3341 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0306 | 0.3628 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0171 | 0.1824 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.0609 | 0.3341 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0306 | 0.3628 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0609 | 0.3341 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0065 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0065 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.0609 | 0.3341 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0306 | 0.3628 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0609 | 0.3341 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0171 | 0.1824 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0065 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0171 | 0.1824 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.0609 | 0.3341 |
Toxoplasma gondii | hypothetical protein | 0.0081 | 0.0609 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0171 | 0.1824 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0306 | 0.3628 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.0609 | 0.3341 |
Leishmania major | carbonic anhydrase-like protein | 0.0171 | 0.1824 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0081 | 0.0609 | 0.3341 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.0609 | 0.3341 |
Schistosoma mansoni | alpha-glucosidase | 0.0135 | 0.1343 | 0.7365 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0157 | 0.1636 | 0.1636 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0171 | 0.1824 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0065 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0609 | 0.3341 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.0609 | 0.3341 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0157 | 0.1636 | 0.8971 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.0609 | 0.3341 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.0609 | 0.3341 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0171 | 0.1824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0609 | 0.3341 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0171 | 0.1824 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.0609 | 0.3341 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0306 | 0.3628 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.004 | 0.0065 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0171 | 0.1824 | 0.1824 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.0609 | 0.3341 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0306 | 0.3628 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0171 | 0.1824 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Neurotoxicity in Swiss Albino mouse at 30 mg/kg after 0.5 hrs by rotorod test | ChEMBL. | 17572089 |
Activity (ADMET) | 0 | Neurotoxicity in Swiss Albino mouse at 30 mg/kg after 4 hrs by rotorod test | ChEMBL. | 17572089 |
Activity (functional) | = 66.6 % | Anticonvulsant activity in Swiss Albino mouse at 30 mg/kg after 0.5 hrs by MES screen test | ChEMBL. | 17572089 |
Activity (functional) | = 66.6 % | Anticonvulsant activity in swiss Albino mouse at 30 mg/kg after 4 hrs by MES screen test | ChEMBL. | 17572089 |
Activity (functional) | = 66.6 % | Anticonvulsant activity in Swiss Albino mouse at 30 mg/kg after 0.5 hrs by MES screen test | ChEMBL. | 17572089 |
Activity (functional) | = 66.6 % | Anticonvulsant activity in swiss Albino mouse at 30 mg/kg after 4 hrs by MES screen test | ChEMBL. | 17572089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.