TDR Targets

Basic information

Technical information

TDR Targets ID: 44529
Name: (3R,8aR)-3-[[tert-butyl(diphenyl)silyl]oxymet hyl]-8a-methoxy-3,6,6,8,8-pentamethyl-1,2-ben zodioxine-5,7-dione
MW: 536.731 | Formula: C31H40O6Si
H donors: 0 H acceptors: 2 LogP: 6.62 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: CO[C@]12OO[C@@](C=C1C(=O)C(C(=O)C2(C)C)(C)C)(C)CO[Si](C(C)(C)C)(c1ccccc1)c1ccccc1
InChi: 1S/C31H40O6Si/c1-27(2,3)38(22-16-12-10-13-17-22,23-18-14-11-15-19-23)35-21-30(8)20-24-25(32)28(4,5)26(33)29(6,7)31(24,34-9)37-36-30/h10-20H,21H2,1-9H3/t30-,31+/m1/s1
InChiKey: KMWRGFLHLJJULY-JSOSNVBQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3R,8aR)-3-[[tert-butyl(diphenyl)silyl]oxymethyl]-8a-methoxy-3,6,6,8,8-pentamethyl-1,2-benzodioxine-5,7-quinone
(3R,8aR)-3-[(tert-butyl-di(phenyl)silyl)oxymethyl]-8a-methoxy-3,6,6,8,8-pentamethyl-1,2-benzodioxine-5,7-dione
(3R,8aR)-3-[(tert-butyl-di(phenyl)silyl)oxymethyl]-8a-methoxy-3,6,6,8,8-pentamethyl-1,2-benzodioxine-5,7-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.4783	1	1
Brugia malayi	Dopamine receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Schistosoma mansoni	lamin	0.0026	0.0029	0.0489
Echinococcus granulosus	hypothetical protein	0.0019	0.0014	0.0297
Schistosoma mansoni	hypothetical protein	0.0047	0.0072	0.1908
Onchocerca volvulus		0.0026	0.0029	0.2562
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0072	0.007
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0014	0.0297
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0014	0.0014
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0072	0.1908
Brugia malayi	intermediate filament protein	0.0026	0.0029	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0014	0.0297
Brugia malayi	hypothetical protein	0.0119	0.0224	0.0221
Brugia malayi	RE15519p	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0029	0.0029
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0014	0.0014
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0014	0.0297
Brugia malayi	Serotonin receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.418779	0.5	0.5
Brugia malayi	GnHR receptor homolog	0.0019	0.0014	0.0011
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.0014	0.0011
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0014	0.0297
Schistosoma mansoni	lamin	0.0026	0.0029	0.0489
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Brugia malayi	neuropeptide F receptor	0.0019	0.0014	0.0011
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0029	0.0026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0014	0.0297
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0014	0.0014
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0014	0.0297
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Brugia malayi	hypothetical protein	0.0035	0.0047	0.0044
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0014	0.0297
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0014	0.0297
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0047	0.1028
Entamoeba histolytica	hypothetical protein	0.0035	0.0047	0.5
Onchocerca volvulus		0.0026	0.0029	0.2562
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.4783	1	1
Echinococcus multilocularis	musashi	0.0026	0.0029	0.0624
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.418779	0.5	0.5
Echinococcus multilocularis	lamin	0.0026	0.0029	0.0624
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0014	0.0297
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0014	0.0297
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0014	0.0297
Brugia malayi	Serotonin receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0245	0.0487	0.0487
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	geminin	0.0166	0.0322	0.7001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.4783	1	1
Loa Loa (eye worm)	hypothetical protein	0.0311	0.0626	0.0626
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0014	0.0297
Brugia malayi	G-protein coupled receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Brugia malayi	NNMT/PNMT/TEMT family protein	0.418779	0.5	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.0014	0.0297
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0014	0.0014
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0014	0.0297
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0014	0.0297
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0014	0.0011
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0014	0.0014
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0014	0.0297
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0014	0.0011
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Entamoeba histolytica	hypothetical protein	0.0035	0.0047	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0014	0.0297
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Brugia malayi	follicle stimulating hormone receptor	0.0245	0.0487	0.0484
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0047	0.109
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0014	0.0011
Schistosoma mansoni	hypothetical protein	0.0166	0.0322	1
Onchocerca volvulus		0.0047	0.0072	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0014	0.0297
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0014	0.0011
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0014	0.0014
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0029	0.0029
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0014	0.0297
Echinococcus granulosus	lamin	0.0026	0.0029	0.0624
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0014	0.0297
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0014	0.0297
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0014	0.0297
Echinococcus multilocularis	serotonin receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0014	0.0297
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0047	0.1028
Brugia malayi	G-protein coupled receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.0014	0.0297
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.046	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0014	0.0297
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0003	0.0003
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0014	0.0011
Brugia malayi	hypothetical protein	0.0232	0.046	0.0457
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0014	0.0297
Brugia malayi	putative neuropeptide receptor	0.0019	0.0014	0.0011
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.0014	0.0297
Echinococcus granulosus	intermediate filament protein	0.0026	0.0029	0.0624
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0014	0.0297
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0014	0.0297
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.046	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0014	0.0297
Entamoeba histolytica	hypothetical protein	0.0035	0.0047	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0014	0.0297
Schistosoma mansoni	hypothetical protein	0.0035	0.0047	0.109
Loa Loa (eye worm)	hypothetical protein	0.0232	0.046	0.046
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0014	0.0297
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0014	0.0297
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0014	0.0014
Brugia malayi	sulfakinin receptor protein	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	sex peptide receptor	0.0019	0.0014	0.0297
Echinococcus multilocularis	serotonin receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0014	0.0297
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0014	0.0011
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0014	0.0297
Brugia malayi	G protein-coupled receptor	0.0019	0.0014	0.0011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.0014	0.0297
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Brugia malayi	larval opioid receptor	0.0019	0.0014	0.0011
Echinococcus granulosus	lamin dm0	0.0026	0.0029	0.0624
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0014	0.0011
Echinococcus multilocularis	geminin	0.0166	0.0322	0.7001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0014	0.0297
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Entamoeba histolytica	hypothetical protein	0.0035	0.0047	0.5
Brugia malayi	hypothetical protein	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0014	0.0297
Brugia malayi	neuropeptide F receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	serotonin receptor	0.0019	0.0014	0.0297
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0014	0.0297
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0029	0.0489
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0014	0.0297
Brugia malayi	AKH receptor	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0028	0.0028
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0014	0.0297
Echinococcus granulosus	somatostatin receptor	0.0019	0.0014	0.0297
Schistosoma mansoni	hypothetical protein	0.0166	0.0322	1
Loa Loa (eye worm)	hypothetical protein	0.418779	0.5	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0014	0.0297
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0014	0.0297
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0014	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0014	0.0297
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0014	0.0011
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0014	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0014	0.0014
Echinococcus multilocularis	lamin dm0	0.0026	0.0029	0.0624
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0014	0.0011

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.5 uM	In vitro inhibition of Plasmodium falciparum growth was determined by using incorporated [3H]- hypoxanthine	ChEMBL.	15006377
IC50 (functional)	= 1.5 uM	In vitro inhibition of Plasmodium falciparum growth was determined by using incorporated [3H]- hypoxanthine	ChEMBL.	15006377

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	15006377

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11016960

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 44529