Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.035 | 0.2669 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.1658 | 0.095 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0123 | 0.0703 | 0.0657 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0123 | 0.0703 | 0.3167 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.2219 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0175 | 0.1154 | 0.38 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0123 | 0.0703 | 0.3167 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.0859 | 0.3871 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0175 | 0.1154 | 0.38 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0132 | 0.0783 | 0.0737 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.0465 | 0.0437 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1195 | 1 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0797 | 0.6549 | 0.648 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0797 | 0.6549 | 0.6256 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.2219 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.111 | 0.1117 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0175 | 0.1154 | 0.5201 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0175 | 0.1154 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1195 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0123 | 0.0703 | 0.1953 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0797 | 0.6549 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.1658 | 0.095 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0797 | 0.6549 | 0.6532 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0797 | 0.6549 | 0.6256 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0175 | 0.1154 | 0.111 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0175 | 0.1154 | 0.0978 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0079 | 0.0358 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.0615 | 0.4974 | 0.7163 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0132 | 0.0783 | 0.2283 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0123 | 0.0703 | 0.3167 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0132 | 0.0783 | 0.2283 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0175 | 0.1154 | 0.0402 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0175 | 0.1154 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.0859 | 0.1031 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.2219 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0797 | 0.6549 | 0.6842 |
Schistosoma mansoni | alpha glucosidase | 0.0175 | 0.1154 | 0.1163 |
Trypanosoma brucei | glucosidase, putative | 0.0175 | 0.1154 | 0.5201 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0132 | 0.0783 | 0.1783 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0175 | 0.1154 | 0.38 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1658 | 0.1493 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0123 | 0.0703 | 0.1953 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0175 | 0.1154 | 0.2977 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0175 | 0.1154 | 0.0402 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.035 | 0.2669 | 1 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0123 | 0.0703 | 0.0927 |
Schistosoma mansoni | alpha-glucosidase | 0.1143 | 0.9549 | 1 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0132 | 0.0783 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1195 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0175 | 0.1154 | 0.38 |
Onchocerca volvulus | 0.086 | 0.7094 | 1 | |
Toxoplasma gondii | Amylo-alpha-1,6-glucosidase | 0.0132 | 0.0783 | 0.663 |
Brugia malayi | hypothetical protein | 0.0233 | 0.1658 | 0.1617 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.2219 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0175 | 0.1154 | 0.38 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0703 | 0.0518 |
Schistosoma mansoni | alpha-glucosidase | 0.1143 | 0.9549 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.0859 | 0.3871 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0175 | 0.1154 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1195 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0123 | 0.0703 | 0.1953 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0123 | 0.0703 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0783 | 0.06 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0175 | 0.1154 | 0.5201 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0615 | 0.4974 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (ADMET) | = 120 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (ADMET) | = 120 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 225 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 225 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.