Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine phosphatase, non-receptor type 1 | Starlite/ChEMBL | References |
Homo sapiens | protein tyrosine phosphatase, non-receptor type 6 | Starlite/ChEMBL | References |
Saccharomyces cerevisiae | Ptp1p | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0597 | 1 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0302 | 0.318 | 0.318 |
Loa Loa (eye worm) | hypothetical protein | 0.0597 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0246 | 0.1886 | 0.1886 |
Schistosoma mansoni | patched 1 | 0.0246 | 0.1886 | 0.1886 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.028 | 0.2678 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.028 | 0.2678 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0302 | 0.318 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0246 | 0.1886 | 0.1886 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0597 | 1 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0302 | 0.318 | 0.318 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0246 | 0.1886 | 0.1886 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0597 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0441 | 0.6394 | 0.6394 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.028 | 0.2678 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0597 | 1 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0441 | 0.6394 | 0.6394 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0597 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0246 | 0.1886 | 0.1886 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0246 | 0.1886 | 0.1886 |
Echinococcus multilocularis | protein patched | 0.0246 | 0.1886 | 0.1886 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0246 | 0.1886 | 0.1886 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0246 | 0.1886 | 0.1886 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0597 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.0246 | 0.1886 | 0.1886 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0441 | 0.6394 | 0.6394 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0441 | 0.6394 | 0.6394 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0246 | 0.1886 | 0.1886 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0441 | 0.6394 | 0.6394 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0302 | 0.318 | 0.318 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.028 | 0.2678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1886 | 0.1886 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0597 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0597 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 uM | Inhibition of PTP1B after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 5 uM | Inhibition of PTP1B after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 13 uM | Inhibition of SHP-1 catalytic domain after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 13 uM | Inhibition of SHP-1 catalytic domain after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 17 uM | Inhibition of yeast PTP1 after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 17 uM | Inhibition of yeast PTP1 after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 21 uM | Inhibition of YOP after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 65 uM | Inhibition of TC-PTP after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | = 65 uM | Inhibition of TC-PTP after 10 mins | ChEMBL. | 17728130 |
IC50 (binding) | > 200 uM | Inhibition of LAR-D1 after 10 mins | ChEMBL. | 17728130 |
Selectivity ratio (binding) | = 5 | Selectivity for PTP1B over TC-PTP | ChEMBL. | 17728130 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.