Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0247 | 0.0545 |
Mycobacterium ulcerans | DNA-3-methyladenine glycosylase I TagA | 0.0187 | 0.2016 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0069 | 0.5 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0073 | 0.055 | 0.1214 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0383 | 0.4529 | 0.4529 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0247 | 0.0545 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0069 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0069 | 0.5 |
Trichomonas vaginalis | DNA-3-methyladenine glycosylase, putative | 0.0187 | 0.2016 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0069 | 0.0152 |
Onchocerca volvulus | 0.0073 | 0.055 | 1 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0045 | 0.0098 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0073 | 0.055 | 0.1214 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0194 | 0.2105 | 0.4648 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0247 | 0.0545 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0189 | 0.2032 | 0.4486 |
Brugia malayi | DOMON domain containing protein | 0.0073 | 0.055 | 0.1214 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0073 | 0.055 | 0.1214 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0069 | 0.0077 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0069 | 0.0077 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0383 | 0.4529 | 0.5074 |
Brugia malayi | DOMON domain containing protein | 0.0073 | 0.055 | 0.1214 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0069 | 0.0152 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0383 | 0.4529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0045 | 0.0098 |
Brugia malayi | DOMON domain containing protein | 0.0073 | 0.055 | 0.1214 |
Onchocerca volvulus | 0.0073 | 0.055 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0247 | 0.0545 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0725 | 0.8925 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0045 | 0.005 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0069 | 0.5 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0383 | 0.4529 | 0.5074 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0383 | 0.4529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.4529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.4529 | 1 |
Mycobacterium tuberculosis | Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g | 0.0093 | 0.0802 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0069 | 0.0069 |
Mycobacterium leprae | PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g | 0.0093 | 0.0802 | 0.5 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0383 | 0.4529 | 1 |
Trichomonas vaginalis | DNA-3-methyladenine glycosylase, putative | 0.0187 | 0.2016 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 740 nM | Displacement of TAMRA labeled dexamethasone at human progesterone receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | > 740 nM | Displacement of TAMRA labeled mifepristone at human mineralocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | > 740 nM | Displacement of TAMRA labeled dexamethasone at human progesterone receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | > 740 nM | Displacement of TAMRA labeled mifepristone at human mineralocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 1125 nM | Displacement of TAMRA labeled dexamethasone at human glucocorticoid receptor in insect cell | ChEMBL. | 17692519 |
IC50 (binding) | = 1125 nM | Displacement of TAMRA labeled dexamethasone at human glucocorticoid receptor in insect cell | ChEMBL. | 17692519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.