Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyl diphosphate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protein kinase 5 | 0.2469 | 0.3069 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.2469 | 0.3069 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0489 | 0.0412 | 0.1343 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0975 | 0.1064 | 0.1837 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.2469 | 0.3069 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.2469 | 0.3069 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2469 | 0.3069 | 0.2888 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.2469 | 0.3069 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0489 | 0.0412 | 0.0162 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.2469 | 0.3069 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0372 | 0.0255 | 0.5 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.0372 | 0.0255 | 0.0829 |
Echinococcus granulosus | cyclin dependent kinase | 0.2469 | 0.3069 | 0.2888 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0489 | 0.0412 | 0.1343 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.2469 | 0.3069 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.2469 | 0.3069 | 0.2888 |
Brugia malayi | cell division control protein 2 homolog | 0.2469 | 0.3069 | 0.639 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.0372 | 0.0255 | 0.0829 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.2469 | 0.3069 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.2469 | 0.3069 | 0.2888 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.7635 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.3655 | 0.466 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.0372 | 0.0255 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.3655 | 0.466 | 0.4521 |
Giardia lamblia | Kinase, CMGC CDK | 0.2469 | 0.3069 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0372 | 0.0255 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2469 | 0.3069 | 0.639 |
Plasmodium vivax | protein kinase Crk2 | 0.2469 | 0.3069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2443 | 0.3034 | 0.2852 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.2469 | 0.3069 | 0.2888 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.2469 | 0.3069 | 0.2888 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0372 | 0.0255 | 0.0829 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0489 | 0.0412 | 0.0358 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.2469 | 0.3069 | 1 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.0372 | 0.0255 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2469 | 0.3069 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0489 | 0.0412 | 0.0162 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.2469 | 0.3069 | 0.2888 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.2469 | 0.3069 | 0.2888 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0489 | 0.0412 | 0.1343 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.2469 | 0.3069 | 1 |
Leishmania major | 0.0489 | 0.0412 | 0.056 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.2469 | 0.3069 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0489 | 0.0412 | 0.1343 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0975 | 0.1064 | 0.083 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.2469 | 0.3069 | 0.2888 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0489 | 0.0412 | 0.0162 |
Giardia lamblia | Kinase, CMGC CDK | 0.2469 | 0.3069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3655 | 0.466 | 0.4521 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0489 | 0.0412 | 0.0162 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.2469 | 0.3069 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.2469 | 0.3069 | 0.2888 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.2469 | 0.3069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.7635 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2469 | 0.3069 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.7635 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2469 | 0.3069 | 0.2888 |
Echinococcus multilocularis | cyclin dependent kinase | 0.2469 | 0.3069 | 0.2888 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.2469 | 0.3069 | 0.2888 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.6 | Growth inhibition of human MCF7 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (functional) | = 3.7 | Growth inhibition of human SF268 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (functional) | = 4 | Growth inhibition of human NCI-H460 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (binding) | = 4.2 | Inhibition of human recombinant geranylgeranyl diphosphate synthase | ChEMBL. | 18800762 |
IC50 (binding) | = 6.3 | Inhibition of human FPPS | ChEMBL. | 17963374 |
IC50 (binding) | = 0.53 uM | Inhibition of human FPPS | ChEMBL. | 17963374 |
IC50 (binding) | = 0.53 uM | Inhibition of human FPPS | ChEMBL. | 17963374 |
IC50 (binding) | = 66.07 uM | Inhibition of human recombinant geranylgeranyl diphosphate synthase | ChEMBL. | 18800762 |
IC50 (functional) | = 95.5 uM | Growth inhibition of human NCI-H460 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (functional) | = 95.5 uM | Growth inhibition of human NCI-H460 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (functional) | = 223 uM | Growth inhibition of human SF268 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (functional) | = 223 uM | Growth inhibition of human SF268 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (functional) | = 239.88 uM | Growth inhibition of human MCF7 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
IC50 (functional) | = 239.88 uM | Growth inhibition of human MCF7 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
Log IC50 (functional) | = 3.6 | Growth inhibition of human MCF7 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
Log IC50 (functional) | = 3.7 | Growth inhibition of human SF268 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
Log IC50 (functional) | = 4 | Growth inhibition of human NCI-H460 cells after 4 days by MTT assay | ChEMBL. | 17963374 |
Log IC50 (binding) | = 6.3 | Inhibition of human FPPS | ChEMBL. | 17963374 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.